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公开(公告)号：US20050152927A1
公开(公告)日：2005-07-14
申请号：US10931260
申请日：2004-08-30
申请人： Irwin Griffith , Joanne Pollock , Julian Bond , Richard Garman , Mei-Chang Kuo , Stephen Powers , Mark Exley , Xian Chen , Ze'ev Shaked
发明人： Irwin Griffith , Joanne Pollock , Julian Bond , Richard Garman , Mei-Chang Kuo , Stephen Powers , Mark Exley , Xian Chen , Ze'ev Shaked
IPC分类号： A61K38/00 , A61K39/00 , C07K14/415 , C07K16/16 , A61K39/35
CPC分类号： C07K14/415 , A61K38/00 , A61K39/00 , C07K16/16
摘要： The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding naturally-occurring allergen or portion thereof but having reduced side effects. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions, and multipeptide formulations comprising one or more peptides of the invention are also provided.
摘要翻译： 本发明提供了编码粳稻主要花粉过敏原Cryj I，Cryj II，Jun s I和Jun v I的核酸序列及其片段或肽。 本发明还提供纯化的Cry j I，Cryj II，Jun s I和Jun v I，以及在用编码Cryj I，Cryj II，Jun的核酸序列转化的宿主细胞中产生的至少一个片段 I和Jun v I或其至少一个片段，以及Cry j I，Cry j II，Jun s I或Jun v I或其至少一个片段的片段，以及Cryj I，Cryj II，Jun 我或Jun v我合成了。 Cry j I，Cry j II，Jun s I和Jun v I及其片段可用于诊断，治疗和预防日本雪松花粉病。 本发明还提供了Cryj I和Cryj II的分离的肽。 本发明范围内的肽包含至少一个T细胞表位，或优选至少两个Cryj I或Cryj II的T细胞表位。 本发明还涉及与相应的天然存在的变应原或其部分具有相似或增强的治疗性质但具有减少的副作用的改性肽。 还提供了治疗或诊断个体对日本雪松花粉和治疗组合物的方法，以及包含一种或多种本发明的肽的多肽制剂。
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公开(公告)号：US20050152848A1
公开(公告)日：2005-07-14
申请号：US10980652
申请日：2004-11-02
申请人： John Patton , Mei-Chang Kuo , J. Harris , Chester Leach , Kimberly Perkins , Blaine Bueche
发明人： John Patton , Mei-Chang Kuo , J. Harris , Chester Leach , Kimberly Perkins , Blaine Bueche
IPC分类号： A61K9/08 , A61K9/12 , A61K9/19 , A61K9/24 , A61K9/72 , A61K38/00 , A61K38/16 , A61K38/28 , A61K47/34 , A61K47/48 , A61L9/04 , A61P3/10 , C07K14/62 , A61K9/14
摘要： The present invention provides active, hydrophilic polymer-modified derivatives of insulin. The insulin derivatives of the invention are, in one aspect, suitable for delivery to the lung and exhibit pharmakokinetic and/or pharmacodynamic properties that are significantly improved over native insulin.
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公开(公告)号：US06835372B2
公开(公告)日：2004-12-28
申请号：US10313343
申请日：2002-12-06
IPC分类号： A61B5055
CPC分类号： A61K9/0075 , A61K9/008 , A61K9/145 , A61K47/183
摘要： The present invention provides a highly dispersible formulation comprising an active agent and a dipeptide or tripeptide comprising at least two leucyl residues. The composition of the invention possesses superior aerosol properties and is thus preferred for aerosolized administration to the lung. Also provided are a method for (i) increasing the dispersibility of an active-agent containing formulation for administration to the lung, and (ii) delivery of the composition to the lungs of a subject.
摘要翻译： 本发明提供了包含活性剂和包含至少两个亮氨酰残基的二肽或三肽的高度可分散的制剂。 本发明的组合物具有优异的气溶胶性质，因此优选雾化给予肺。 还提供了用于（i）增加含有活性剂的制剂用于给予肺的分散性的方法，和（ii）将组合物递送至受试者的肺。
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公开(公告)号：US06518239B1
公开(公告)日：2003-02-11
申请号：US09548759
申请日：2000-04-13
IPC分类号： A01N3718
CPC分类号： A61K9/0075 , A61K9/008 , A61K9/145 , A61K47/183
摘要： The present invention provides a highly dispersible formulation comprising an active agent and a dipeptide or tripeptide comprising at least two leucyl residues. The composition of the invention possesses superior aerosol properties and is thus preferred for aerosolized administration to the lung. Also provided are a method for (i) increasing the dispersibility of an active-agent containing formulation for administration to the lung, and (ii) delivery of the composition to the lungs of a subject.
摘要翻译： 本发明提供了包含活性剂和包含至少两个亮氨酰残基的二肽或三肽的高度可分散的制剂。 本发明的组合物具有优异的气溶胶性质，因此优选雾化给予肺。 还提供了用于（i）增加含有活性剂的制剂用于给予肺的分散性的方法，和（ii）将组合物递送至受试者的肺。
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