公开(公告)号：US06797257B2

公开(公告)日：2004-09-28

申请号：US09976746

申请日：2001-10-12

申请人： Michael A. McDonald ,  Kenneth L. Watkin

发明人： Michael A. McDonald ,  Kenneth L. Watkin

IPC分类号： A61B5055

CPC分类号： B82Y5/00 ,  A61K9/5052 ,  A61K41/009 ,  A61K49/1821 ,  A61K49/225

摘要： The present invention relates to a composition that includes gadolinium particles encapsulated in microsphere shells. The composition is suitable for use as a contrast agent with a plurality of imaging modalities, including, for example, ultrasound, magnetic resonance imaging, and computed temography. The compositions also are useful for therapeutic applications, including neutron capture therapy.

摘要翻译： 本发明涉及包含微球壳的钆颗粒的组合物。 该组合物适用于具有多种成像方式的造影剂，包括例如超声，磁共振成像和计算的造影。 组合物还可用于治疗应用，包括中子捕获治疗。

公开(公告)号：US06782286B2

公开(公告)日：2004-08-24

申请号：US09294148

申请日：1999-04-20

申请人： Mitsue Miyazaki

发明人： Mitsue Miyazaki

IPC分类号： A61B5055

CPC分类号： G01R33/563 ,  G01R33/5673

摘要： Without injecting a contrast medium, blood pumped out from the heart can preferably be depicted in a non-invasive fashion, resulting in a greatly shortened scanning time for data acquisition. An MRI system temporal phase detector acquires an ECG signal of an object, and an imaging scanner performs a three-dimensional scanning pulse sequence every slice encoding in synchronism with an ECG signal. The pulse sequence includes an RF excitation pulse for which a repetition time is set to be shorter than conventional. In addition, the pulse sequence includes a slice-directional gradient for performing data acquisition based on the slice encoding in an approximately parallel direction to a running direction of blood flow. Furthermore, the pulse sequence includes a phase-encoding directional gradient for applying phase encoding in a direction approximately coinciding with a running direction of the blood flow.

摘要翻译： 不注射造影剂，可以优选以非侵入性方式描绘从心脏抽出的血液，导致用于数据采集的扫描时间大大缩短。 MRI系统时间相位检测器获取对象的ECG信号，并且成像扫描器与ECG信号同步地执行每个切片编码的三维扫描脉冲序列。 脉冲序列包括重复时间设置为比常规短的RF激励脉冲。 此外，脉冲序列包括用于基于在与血流的行进方向大致平行的方向上的切片编码来执行数据采集的切片方向梯度。 此外，脉冲序列包括用于在大致与血流的行进方向一致的方向上施加相位编码的相位编码方向梯度。

公开(公告)号：US06768915B2

公开(公告)日：2004-07-27

申请号：US10027849

申请日：2001-12-21

申请人： Martin Brand ,  Rainer Kuth

发明人： Martin Brand ,  Rainer Kuth

IPC分类号： A61B5055

CPC分类号： G01R33/4806 ,  A61B5/055 ,  A61B5/7285

摘要： In a method for the operation of a magnetic resonance apparatus, a prescribable event that can trigger a neural activity of an examination subject is initiated, the implementation of the event and the readiness of the examination subject to perceive the event that triggers the neural activity are monitored, and given a positive result of the monitoring, an image dataset of a region of the examination subject to be imaged, and to which the event can be allocated, is registered.

摘要翻译： 在磁共振装置的操作方法中，启动可以触发检查对象的神经活动的规定事件，事件的实现和检查对象感知触发神经活动的事件的准备状态是 监视并给出监视的肯定结果，登记要被成像的检查区域的图像数据集，并且可以分配事件。

公开(公告)号：US06741881B2

公开(公告)日：2004-05-25

申请号：US10212527

申请日：2002-08-05

申请人： Martin R. Prince

发明人： Martin R. Prince

IPC分类号： A61B5055

CPC分类号： A61K49/18 ,  A61B5/201 ,  A61B5/411 ,  A61B5/416 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308 ,  G01R33/5635

摘要： The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins. The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g., about 20-50% greater than the response of the region of interest to a series of magnetic resonance pulses before administration of a magnetic resonance contrast agent), a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention facilitates synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement. The center of k-space corresponds to the lowest spatial frequency data which dominates image contrast.

公开(公告)号：US06714808B2

公开(公告)日：2004-03-30

申请号：US09970456

申请日：2001-10-03

申请人： V. Suzanne Klimberg ,  Steven E. Harms ,  Sohelia Korourian

发明人： V. Suzanne Klimberg ,  Steven E. Harms ,  Sohelia Korourian

IPC分类号： A61B5055

CPC分类号： A61B90/39 ,  A61B10/0233 ,  A61B2090/374 ,  A61B2090/378 ,  A61B2090/3908

摘要： A novel method of hematoma-directed ultrasound guided excisional breast biopsy is disclosed. In one aspect of the inventon, the hematoma is produced by an injection of the patient's own blood into a pre-selected area to target a lesion. Detection of the targeted lesion and hematoma is achieved with MRI. In a second aspect of the invention, the hematoma is produced by stereotactic core needle breast biopsy in a pre-selected area, and the targeted lesion and hematoma are detected using intraoperative ultrasound. The method avoids many of the disadvantages associated with traditional needle localized breast biopsy. The method can also be used to guide the excision of lesions visualized by MRI, ultrasound, mammography, PET scanning, and scintimammography. The method may be used in any organ and, in particular, the breast.

摘要翻译： 公开了一种血肿导向超声引导切除乳腺活检的新方法。 在本发明的一个方面，血肿是通过将患者自己的血液注射到预选区域来靶向病变而产生的。 用MRI检测目标病变和血肿。 在本发明的第二方面中，通过在预选区域中的立体定向核心针乳房活检产生血肿，并且使用术中超声检测靶向病变和血肿。 该方法避免了与传统针定位乳腺活检相关的许多缺点。 该方法还可用于指导通过MRI，超声，乳房X线照相术，PET扫描和闪烁扫描显像的病变切除。 该方法可用于任何器官，特别是乳房。

公开(公告)号：US06714807B2

公开(公告)日：2004-03-30

申请号：US09896764

申请日：2001-06-29

申请人： Yuval Zur

发明人： Yuval Zur

IPC分类号： A61B5055

CPC分类号： G01R33/5613

摘要： A method for performing MRI, including imposing N sets of steady-state free precession (SSFP) sequences on an object to be imaged, the sequences including respective initial radio-frequency (RF) excitation pulses, each initial RF excitation pulse having a predetermined phase shift relative to the other initial RF excitation pulses. N is a whole number larger than one and less than six. The method further includes setting the phase shift of the RF pulse of the sequences so that the phase shift of the RF pulse of an Mth sequence is substantially equal to 2 ⁢ π ⁡ ( M - 1 ) N radians, wherein M is a whole number larger than 0 and less than or equal to N, receiving a respective set of image signals from the object responsive to the N sets of SSFP sequences, and processing the set of received image signals to generate an image of the object.

摘要翻译： 一种用于执行MRI的方法，包括在待成像对象上施加N组稳态自由进动（SSFP）序列，所述序列包括相应的初始射频（RF）激励脉冲，每个初始RF激励脉冲具有预定相位 相对于其他初始RF激励脉冲移位。 N是大于1且小于6的整数。 该方法还包括设置序列的RF脉冲的相移，使得M个序列的RF脉冲的相移基本上相等于toradians，其中M是大于0且小于或等于0的整数 到N，响应于N组SSFP序列从对象接收相应的一组图像信号，以及处理所接收的图像信号的集合以生成对象的图像。

公开(公告)号：US06701178B2

公开(公告)日：2004-03-02

申请号：US10283292

申请日：2002-10-30

申请人： Sunyu Su ,  Leon Kaufman

发明人： Sunyu Su ,  Leon Kaufman

IPC分类号： A61B5055

CPC分类号： G01R33/3415

摘要： An inherently de-coupled sandwiched solenoidal array coil (SSAC) is disclosed for use in receiving nuclear magnetic resonance (NMR) radio frequency (RF) signals in both horizontal and vertical-field magnetic resonance imaging (MRI) systems. In its most basic configuration, the SSAC comprises two coaxial RF receive coils. The first coil of the array has two solenoidal (or loop) sections that are separated from one another along a common axis. The two sections are electrically connected in series but the conductors in each section are wound in opposite directions so that a current through the coil sets up a magnetic field of opposite polarity in each section. The second coil of the SSAC is disposed (“sandwiched”) between the two separated solenoidal sections of the first coil in a region where the combined opposing magnetic fields cancel to become a null. Due to the winding arrangement and geometrical symmetry, the receive coils of the array become electromagnetically “de-coupled” from one another while still maintaining their sensitivity toward receiving NMR signals. The multiple coil array arrangement also allows for selecting between a larger or smaller field-of-view (FOV) to avoid image fold-over problems without time penalty in image data acquisition. Alternative embodiments are disclosed which include unequal constituent coil diameters, unequal constituent coil windings, non-coaxial coil configurations, a three-coil quadrature detection (QD) SSAC arrangement, multiple SSAC arrangements, and optimized SSAC configurations for breast imaging in both horizontal and vertical-field MRI systems.

摘要翻译： 公开了一种固有的去耦合的夹层螺线管阵列线圈（SSAC），用于在水平和垂直场磁共振成像（MRI）系统中接收核磁共振（NMR）射频（RF）信号。 在其最基本的配置中，SSAC包括两个同轴RF接收线圈。 阵列的第一个线圈具有沿公共轴彼此分离的两个螺线管（或环）部分。 两个部分串联电连接，但是每个部分中的导体沿相反的方向缠绕，使得通过线圈的电流在每个部分中建立相反极性的磁场。 SSAC的第二线圈在组合的相对磁场取消为零的区域中被布置（“夹持”在第一线圈的两个分离的螺线管部分之间）。 由于绕组布置和几何对称性，阵列的接收线圈彼此电磁“去耦合”，同时仍然保持对接收NMR信号的灵敏度。 多线圈阵列布置还允许在更大或更小的视场（FOV）之间进行选择，以避免图像折叠问题，而在图像数据采集中没有时间损失。 公开了包括不等构成线圈直径，不相等的构成线圈绕组，非同轴线圈配置，三线圈正交检测（QD）SSAC布置，多个SSAC布置以及用于乳腺成像在水平和垂直方向上的优化SSAC配置的替代实施例 场MRI系统。

公开(公告)号：US06701177B2

公开(公告)日：2004-03-02

申请号：US10283213

申请日：2002-10-30

申请人： Sunyu Su

发明人： Sunyu Su

IPC分类号： A61B5055

CPC分类号： G01R33/3415

摘要： An inherently de-coupled sandwiched solenoidal array coil (SSAC) is disclosed for use in receiving nuclear magnetic resonance (NMR) radio frequency (RF) signals in both horizontal and vertical-field magnetic resonance imaging (MRI) systems. In its most basic configuration, the SSAC comprises two coaxial RF receive coils. The first coil of the array has two solenoidal (or loop) sections that are separated from one another along a common axis. The two sections are electrically connected in series but the conductors in each section are wound in opposite directions so that a current through the coil sets up a magnetic field of opposite polarity in each section. The second coil of the SSAC is disposed (“sandwiched”) between the two separated solenoidal sections of the first coil in a region where the combined opposing magnetic fields cancel to become a null. Due to the winding arrangement and geometrical symmetry, the receive coils of the array become electromagnetically “de-coupled” from one another while still maintaining their sensitivity toward receiving NMR signals. The multiple coil array arrangement also allows for selecting between a larger or smaller field-of-view (FOV) to avoid image fold-over problems without time penalty in image data acquisition. Alternative embodiments are disclosed which include unequal constituent coil diameters, unequal constituent coil windings, non-coaxial coil configurations, a three-coil quadrature detection (QD) SSAC arrangement, multiple SSAC arrangements, and optimized SSAC configurations for breast imaging in both horizontal and vertical-field MRI systems.

摘要翻译： 公开了一种固有的去耦合的夹层螺线管阵列线圈（SSAC），用于在水平和垂直场磁共振成像（MRI）系统中接收核磁共振（NMR）射频（RF）信号。 在其最基本的配置中，SSAC包括两个同轴RF接收线圈。 阵列的第一个线圈具有沿公共轴彼此分离的两个螺线管（或环）部分。 两个部分串联电连接，但每个部分中的导体沿相反的方向缠绕，使得通过线圈的电流在每个部分中建立相反极性的磁场。 SSAC的第二线圈在组合的相对磁场取消为零的区域中被布置（“夹持”在第一线圈的两个分离的螺线管部分之间）。 由于绕组布置和几何对称性，阵列的接收线圈彼此电磁“去耦合”，同时仍然保持对接收NMR信号的灵敏度。 多线圈阵列布置还允许在更大或更小的视场（FOV）之间进行选择，以避免图像折叠问题，而在图像数据采集中没有时间损失。 公开了包括不等构成线圈直径，不相等的构成线圈绕组，非同轴线圈配置，三线圈正交检测（QD）SSAC布置，多个SSAC布置以及用于乳腺成像在水平和垂直方向上的优化SSAC配置的替代实施例 场MRI系统。

公开(公告)号：US06696040B2

公开(公告)日：2004-02-24

申请号：US09904343

申请日：2001-07-12

申请人： Bastiaan Driehuys

发明人： Bastiaan Driehuys

IPC分类号： A61B5055

CPC分类号： G01R33/5601 ,  A61B5/02755 ,  A61B5/055 ,  A61B5/4088 ,  A61B5/415 ,  A61B5/418 ,  G01R33/4625 ,  Y10T436/24

摘要： An in vivo non-invasive method for detecting and/or diagnosing a pathological condition using hyperpolarized 129Xe spectroscopy is disclosed. Generally stated, the method includes determining the magnitude of spectral peaks which represent particular chemical shifts and comparing the observed magnitudes to those of healthy individuals. Preferably, the method includes subtracting substantial backgrounds and accounting for secondary conditions such as the polarization of hyperpolarized gas administered. Additionally, a quantitative analysis of hyperpolarized 129Xe spectra advantageously allows a physician to establish the extent of disease progression. Advantageously, this method can be used regardless of the method of hyperpolarized 129Xe administration.

摘要翻译： 公开了一种使用超极化Xe光谱法检测和/或诊断病理状况的体内非侵入性方法。 一般来说，该方法包括确定代表特定化学位移的谱峰值的大小，并将观察到的幅度与健康个体的值进行比较。 优选地，该方法包括减去实质背景并考虑二次条件，例如所施用的超极化气体的极化。 另外，超极化Xe光谱的定量分析有利地允许医师建立疾病进展的程度。 有利地，可以使用该方法，而不管超极化Xe施用的方法如何。

公开(公告)号：US06690962B2

公开(公告)日：2004-02-10

申请号：US09952029

申请日：2001-09-14

申请人： Stephen Schmitz ,  Mayk Kresse ,  Susanne Wagner

发明人： Stephen Schmitz ,  Mayk Kresse ,  Susanne Wagner

IPC分类号： A61B5055

CPC分类号： G01R33/5601 ,  A61B5/0263 ,  A61B5/0275 ,  A61K49/1863

摘要： The invention relates to a new process for graphic visualization and diagnosis of thrombi as well as the use of particle suspensions for the production of contrast media for the visualization of thrombi with use of nuclear spin tomography.

摘要翻译： 本发明涉及用于图形可视化和诊断血栓的新方法以及使用颗粒悬浮液来生产用于使用核自旋断层扫描显示血栓的造影剂。