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19 条记录 (耗时 0.028 秒)

    Cross-reference service
    1.
    发明授权
    Cross-reference service 有权
    交叉参考服务

    公开(公告)号：US07716675B2

    公开(公告)日：2010-05-11

    申请号：US10652575

    申请日：2003-08-28

    申请人： Richard Mark Exley ,  Chaochin Wang

    发明人： Richard Mark Exley ,  Chaochin Wang

    IPC分类号： G06F13/00

    CPC分类号： G06F9/541

    摘要： A method and system for providing an integration environment in which integration processes can be developed independent of integration servers and applications. The integration environment provides an application service interface for each application that is independent of the integration servers. An integration process that is developed to use the application service interface is compatible with any integration server that supports the applications that the integration process accesses. The integration environment provides a common service interface for each type of application. The common service interface is independent of the application that is providing the service and is also independent of the integration server. Thus, an integration process developed to use the common service interface is compatible with any application of the appropriate type and any integration server.

    摘要翻译： 一种用于提供集成环境的方法和系统，可以独立于集成服务器和应用程序开发集成过程。 集成环境为独立于集成服务器的每个应用程序提供应用程序服务接口。 开发使用应用程序服务接口的集成过程与支持集成进程访问的应用程序的任何集成服务器兼容。 集成环境为每种类型的应用程序提供了一个通用的服务接口。 公共服务接口独立于提供服务的应用程序，并且还独立于集成服务器。 因此，开发使用公共服务接口的集成过程与适当类型的任何应用程序和任何集成服务器兼容。

    Allergenic proteins and peptides from Japanese cedar pollen
    4.
    发明申请
    Allergenic proteins and peptides from Japanese cedar pollen 有权
    来自日本雪松花粉的过敏蛋白和肽

    公开(公告)号：US20050152927A1

    公开(公告)日：2005-07-14

    申请号：US10931260

    申请日：2004-08-30

    申请人： Irwin Griffith ,  Joanne Pollock ,  Julian Bond ,  Richard Garman ,  Mei-Chang Kuo ,  Stephen Powers ,  Mark Exley ,  Xian Chen ,  Ze'ev Shaked

    发明人： Irwin Griffith ,  Joanne Pollock ,  Julian Bond ,  Richard Garman ,  Mei-Chang Kuo ,  Stephen Powers ,  Mark Exley ,  Xian Chen ,  Ze'ev Shaked

    IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/415 ,  C07K16/16 ,  A61K39/35

    CPC分类号： C07K14/415 ,  A61K38/00 ,  A61K39/00 ,  C07K16/16

    摘要： The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding naturally-occurring allergen or portion thereof but having reduced side effects. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions, and multipeptide formulations comprising one or more peptides of the invention are also provided.

    摘要翻译： 本发明提供了编码粳稻主要花粉过敏原Cryj I，Cryj II，Jun s I和Jun v I的核酸序列及其片段或肽。 本发明还提供纯化的Cry j I，Cryj II，Jun s I和Jun v I，以及在用编码Cryj I，Cryj II，Jun的核酸序列转化的宿主细胞中产生的至少一个片段 I和Jun v I或其至少一个片段，以及Cry j I，Cry j II，Jun s I或Jun v I或其至少一个片段的片段，以及Cryj I，Cryj II，Jun 我或Jun v我合成了。 Cry j I，Cry j II，Jun s I和Jun v I及其片段可用于诊断，治疗和预防日本雪松花粉病。 本发明还提供了Cryj I和Cryj II的分离的肽。 本发明范围内的肽包含至少一个T细胞表位，或优选至少两个Cryj I或Cryj II的T细胞表位。 本发明还涉及与相应的天然存在的变应原或其部分具有相似或增强的治疗性质但具有减少的副作用的改性肽。 还提供了治疗或诊断个体对日本雪松花粉和治疗组合物的方法，以及包含一种或多种本发明的肽的多肽制剂。

    Universal application network architecture
    5.
    发明授权
    Universal application network architecture 有权
    通用应用网络架构

    公开(公告)号：US07694314B2

    公开(公告)日：2010-04-06

    申请号：US10653028

    申请日：2003-08-28

    申请人： Richard Mark Exley ,  Maria Theresa Barnes Leon ,  Hitesh Dholakia ,  Manoj Kumar Das

    发明人： Richard Mark Exley ,  Maria Theresa Barnes Leon ,  Hitesh Dholakia ,  Manoj Kumar Das

    IPC分类号： G06F9/44

    CPC分类号： G06F9/541

    摘要： A method and system for providing an integration environment in which integration processes can be developed independent of integration servers and applications. The integration environment provides an application service interface for each application that is independent of the integration servers. An integration process that is developed to use the application service interface is compatible with any integration server that supports the applications that the integration process accesses. The integration environment provides a common service interface for each type of application. The common service interface is independent of the application that is providing the service and is also independent of the integration server. Thus, an integration process developed to use the common service interface is compatible with any application of the appropriate type and any integration server.

    摘要翻译： 一种用于提供集成环境的方法和系统，可以独立于集成服务器和应用程序开发集成过程。 集成环境为独立于集成服务器的每个应用程序提供应用程序服务接口。 开发使用应用程序服务接口的集成过程与支持集成进程访问的应用程序的任何集成服务器兼容。 集成环境为每种类型的应用程序提供了一个通用的服务接口。 公共服务接口独立于提供服务的应用程序，并且还独立于集成服务器。 因此，开发使用公共服务接口的集成过程与适当类型的任何应用程序和任何集成服务器兼容。

    Use of anti-cd1 antibodies for the modulation of immune responses
    8.
    发明申请
    Use of anti-cd1 antibodies for the modulation of immune responses 有权
    使用抗cd1抗体来调节免疫反应

    公开(公告)号：US20060002927A1

    公开(公告)日：2006-01-05

    申请号：US10513109

    申请日：2003-05-01

    申请人： Mark Exley ,  Steven Balk ,  Simon Yue

    发明人： Mark Exley ,  Steven Balk ,  Simon Yue

    IPC分类号： A61K39/395

    CPC分类号： C07K16/2833 ,  A61K2035/124 ,  A61K2039/505 ,  A61K2039/5158 ,  Y02A50/466

    摘要： The invention provides methods for the administration of an anti-CD 1 antibody for the treatment or prevention of a variety of disorders, such as autoimmune disease, viral infection, bacterial infection, parasitic infection, infection by a eukaryotic pathogen, allergy, asthma, inflammatory condition, graft versus host disease, graft rejection, immunodeficiency disease, spontaneous abortion, pregnancy, and cancer.

    摘要翻译： 本发明提供了用于治疗或预防各种疾病如自身免疫性疾病，病毒感染，细菌感染，寄生虫感染，真核病原体感染，过敏，哮喘，炎性反应的抗CD 1抗体的方法 病情，移植物抗宿主病，移植排斥反应，免疫缺陷病，自然流产，怀孕和癌症。

    Common common object
    10.
    发明授权
    Common common object 有权
    共同的共同对象

    公开(公告)号：US07711680B2

    公开(公告)日：2010-05-04

    申请号：US10809943

    申请日：2004-03-24

    申请人： Maria Theresa Barnes-Leon ,  Nardo B. Catahan, Jr. ,  Richard Mark Exley

    发明人： Maria Theresa Barnes-Leon ,  Nardo B. Catahan, Jr. ,  Richard Mark Exley

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30569 ,  G06Q10/06

    摘要： Enterprise management information in a first format for use by a first computerized system is transformed into an intermediate format to readily make the stored enterprise management information available for use in a second computerized system that utilizes a second format. The transformation includes a plurality of common data type elements that are adapted to be shared across a plurality of data objects in the intermediate format.

    摘要翻译： 用于第一计算机化系统使用的第一格式的企业管理信息被转换为中间格式，以容易地使存储的企业管理信息可用于使用第二格式的第二计算机化系统。 该变换包括适于在中间格式的多个数据对象之间共享的多个公共数据类型元素。