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    Allergenic proteins and peptides from Japanese cedar pollen
    1.
    发明申请
    Allergenic proteins and peptides from Japanese cedar pollen 有权
    来自日本雪松花粉的过敏蛋白和肽

    公开(公告)号：US20050152927A1

    公开(公告)日：2005-07-14

    申请号：US10931260

    申请日：2004-08-30

    申请人： Irwin Griffith ,  Joanne Pollock ,  Julian Bond ,  Richard Garman ,  Mei-Chang Kuo ,  Stephen Powers ,  Mark Exley ,  Xian Chen ,  Ze'ev Shaked

    发明人： Irwin Griffith ,  Joanne Pollock ,  Julian Bond ,  Richard Garman ,  Mei-Chang Kuo ,  Stephen Powers ,  Mark Exley ,  Xian Chen ,  Ze'ev Shaked

    IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/415 ,  C07K16/16 ,  A61K39/35

    CPC分类号： C07K14/415 ,  A61K38/00 ,  A61K39/00 ,  C07K16/16

    摘要： The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding naturally-occurring allergen or portion thereof but having reduced side effects. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions, and multipeptide formulations comprising one or more peptides of the invention are also provided.

    摘要翻译： 本发明提供了编码粳稻主要花粉过敏原Cryj I，Cryj II，Jun s I和Jun v I的核酸序列及其片段或肽。 本发明还提供纯化的Cry j I，Cryj II，Jun s I和Jun v I，以及在用编码Cryj I，Cryj II，Jun的核酸序列转化的宿主细胞中产生的至少一个片段 I和Jun v I或其至少一个片段，以及Cry j I，Cry j II，Jun s I或Jun v I或其至少一个片段的片段，以及Cryj I，Cryj II，Jun 我或Jun v我合成了。 Cry j I，Cry j II，Jun s I和Jun v I及其片段可用于诊断，治疗和预防日本雪松花粉病。 本发明还提供了Cryj I和Cryj II的分离的肽。 本发明范围内的肽包含至少一个T细胞表位，或优选至少两个Cryj I或Cryj II的T细胞表位。 本发明还涉及与相应的天然存在的变应原或其部分具有相似或增强的治疗性质但具有减少的副作用的改性肽。 还提供了治疗或诊断个体对日本雪松花粉和治疗组合物的方法，以及包含一种或多种本发明的肽的多肽制剂。