公开(公告)号：US08263601B2

公开(公告)日：2012-09-11

申请号：US12874783

申请日：2010-09-02

申请人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

发明人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

IPC分类号： C07D473/10 ,  A61K31/522 ,  A61P1/16 ,  A61P13/12 ,  A61P25/02 ,  A61P3/10 ,  C07B59/00

CPC分类号： A61K31/522 ,  C07D473/06

摘要： This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. In particular, this invention relates to novel substituted xanthine derivatives that are derivatives of a pentoxifylline metabolite. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial. The compounds of the invention are represented by one of the following structural formulas: wherein the values of R1, R2, Y1 and Y2 are described herein.

摘要翻译： 本发明涉及作为取代黄嘌呤衍生物的新化合物及其药学上可接受的盐。 特别地，本发明涉及作为己酮可可碱代谢物的衍生物的新的取代黄嘌呤衍生物。 本发明还提供了包含一种或多种本发明化合物和载体的组合物，以及所述化合物和组合物在治疗己酮可可碱和相关化合物有益的疾病和病症的方法中的用途。 本发明的化合物由以下结构式之一表示：其中R1，R2，Y1和Y2的值在本文中描述。

公开(公告)号：US20110172280A1

公开(公告)日：2011-07-14

申请号：US12905835

申请日：2010-10-15

申请人： Julie F. Liu ,  Scott L. Harbeson

发明人： Julie F. Liu ,  Scott L. Harbeson

IPC分类号： A61K31/4184 ,  C07D235/06 ,  A61P25/00 ,  A61P21/00

CPC分类号： C07B59/002 ,  C07D235/06

摘要： This invention relates to novel substituted benzimidazoles and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a compound that modulates the GABAA receptor. This invention also provides novel intermediates for the preparation of the compounds of the invention, and salts thereof.

摘要翻译： 本发明涉及新的取代苯并咪唑及其药学上可接受的盐。 本发明还提供了包含本发明化合物的组合物和这些组合物在治疗通过施用调节GABA A受体的化合物有益治疗的疾病和病症的方法中的用途。 本发明还提供了用于制备本发明化合物及其盐的新型中间体。

公开(公告)号：US20110065711A1

公开(公告)日：2011-03-17

申请号：US12820570

申请日：2010-06-22

申请人： Scott L. Harbeson ,  Roger D. Tung ,  Julie F. Liu

发明人： Scott L. Harbeson ,  Roger D. Tung ,  Julie F. Liu

IPC分类号： A61K31/5025 ,  C07D487/04 ,  A61P25/00 ,  A61P29/00 ,  A61P19/02

CPC分类号： C07D487/04 ,  A61K31/5025 ,  A61K45/06

摘要： This invention relates to novel substituted triazolo-pyridazines and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an α1-GABAA receptor antagonist or an α2- and/or an α3-GABAA receptor partial agonist.

摘要翻译： 本发明涉及新的取代三唑并 - 哒嗪及其药学上可接受的盐。 本发明还提供了包含本发明化合物的组合物和这些组合物在治疗通过施用α1-GABA A受体拮抗剂或α2-和/或α3-GABA A受体部分激动剂有益治疗的疾病和病症的方法中的用途 。

公开(公告)号：US20110059995A1

公开(公告)日：2011-03-10

申请号：US12874049

申请日：2010-09-01

申请人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

发明人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

IPC分类号： A61K31/522 ,  C07D473/04 ,  A61P3/10 ,  A61P1/16 ,  A61P13/12 ,  A61P27/02 ,  A61P31/18

CPC分类号： C07D473/04 ,  C07D473/06

摘要： This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

公开(公告)号：US20090239886A1

公开(公告)日：2009-09-24

申请号：US12380579

申请日：2009-02-27

申请人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

发明人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

IPC分类号： A61K31/522 ,  C07D473/04 ,  A61P13/12

CPC分类号： C07D473/10 ,  C07B2200/05 ,  C07B2200/07 ,  C07D473/04

摘要： This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

摘要翻译： 本发明涉及作为取代黄嘌呤衍生物的新化合物及其药学上可接受的盐。 例如，本发明涉及作为己酮可可碱衍生物的新型取代黄嘌呤衍生物。 本发明还提供了包含一种或多种本发明化合物和载体的组合物，以及所述化合物和组合物在治疗己酮可可碱和相关化合物有益的疾病和病症的方法中的用途。

公开(公告)号：US08952016B2

公开(公告)日：2015-02-10

申请号：US12874049

申请日：2010-09-01

申请人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

发明人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

IPC分类号： A61K31/522 ,  C07D473/04 ,  C07D473/06

CPC分类号： C07D473/04 ,  C07D473/06

摘要： This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. The compound of the invention are represented by one of the following structural formulas: The variables for these structural formulas are described herein. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

摘要翻译： 本发明涉及作为取代黄嘌呤衍生物的新化合物及其药学上可接受的盐。 例如，本发明涉及作为己酮可可碱衍生物的新型取代黄嘌呤衍生物。 本发明的化合物由以下结构式之一表示：这些结构式的变量在本文中描述。 本发明还提供了包含一种或多种本发明化合物和载体的组合物，以及所述化合物和组合物在治疗己酮可可碱和相关化合物有益的疾病和病症的方法中的用途。

公开(公告)号：US08501738B2

公开(公告)日：2013-08-06

申请号：US12820570

申请日：2010-06-22

申请人： Scott L. Harbeson ,  Julie F. Liu

发明人： Scott L. Harbeson ,  Julie F. Liu

IPC分类号： A01N43/58 ,  A61K31/50 ,  C07D487/00

CPC分类号： C07D487/04 ,  A61K31/5025 ,  A61K45/06

摘要： This invention relates to novel substituted triazolo-pyridazines and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an α1-GABAA receptor antagonist or an α2- and/or an α3-GABAA receptor partial agonist.

摘要翻译： 本发明涉及新的取代三唑并 - 哒嗪及其药学上可接受的盐。 本发明还提供了包含本发明化合物和这些组合物在治疗通过施用α1-GABA A受体拮抗剂或α2-和/或α3-GABA A受体部分激动剂有益治疗的疾病和病症的方法中的用途 。

公开(公告)号：US20110077255A1

公开(公告)日：2011-03-31

申请号：US12874783

申请日：2010-09-02

申请人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

发明人： Roger D. Tung ,  Julie F. Liu ,  Scott L. Harbeson

IPC分类号： A61K31/522 ,  C07D473/16 ,  A61P3/10 ,  A61P3/04 ,  A61P3/06 ,  A61P7/06 ,  A61P27/02 ,  A61P11/00

CPC分类号： A61K31/522 ,  C07D473/06

摘要： This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

摘要翻译： 本发明涉及作为取代黄嘌呤衍生物的新化合物及其药学上可接受的盐。 例如，本发明涉及作为己酮可可碱衍生物的新型取代黄嘌呤衍生物。 本发明还提供了包含一种或多种本发明化合物和载体的组合物，以及所述化合物和组合物在治疗己酮可可碱和相关化合物有益的疾病和病症的方法中的用途。

公开(公告)号：US20100305173A1

公开(公告)日：2010-12-02

申请号：US12771551

申请日：2010-04-30

申请人： Scott L. Harbeson ,  Roger D. Tung ,  Julie F. Liu ,  Craig E. Masse

发明人： Scott L. Harbeson ,  Roger D. Tung ,  Julie F. Liu ,  Craig E. Masse

IPC分类号： A61K31/428 ,  C07D493/04 ,  A61K31/34 ,  A61K31/427 ,  A61P31/18 ,  A61P33/06 ,  A61K31/36

CPC分类号： C07D493/04

摘要： This invention relates to novel hydroxyethylamino sulfonamides, their derivatives, pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a compound with the ability to act as an HIV (human immunodeficiency virus) protease inhibitor.

摘要翻译： 本发明涉及新的羟乙基氨基磺酰胺，其衍生物，其药学上可接受的盐。 本发明还提供了包含本发明化合物的组合物和这些组合物在治疗通过施用具有作为HIV（人类免疫缺陷病毒）蛋白酶抑制剂的能力的化合物有益治疗的疾病和病症的方法中的用途。

公开(公告)号：US20100249079A1

公开(公告)日：2010-09-30

申请号：US12644758

申请日：2009-12-22

申请人： Rose A. Persichetti ,  Julie F. Liu ,  Craig E. Masse ,  Scott L. Harbeson

发明人： Rose A. Persichetti ,  Julie F. Liu ,  Craig E. Masse ,  Scott L. Harbeson

IPC分类号： A61K31/4709 ,  C07D401/12 ,  A61K31/616 ,  A61K31/4365 ,  A61P9/00 ,  A61P9/10 ,  A61P29/00 ,  A61P11/06 ,  A61P3/10

CPC分类号： C07D215/20 ,  A61K31/10 ,  A61K31/4365 ,  A61K31/4709 ,  A61K31/60 ,  C07D401/12

摘要： This invention relates to novel compounds which are derivatives of the phosphodiesterase inhibitor, cilostazol and pharmaceutically acceptable salts thereof. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administration of a phosphodiesterase inhibitor, such as cilostazol. The invention also relates to the use of the disclosed compounds and compositions as reagents in analytical studies involving cilostazol.

摘要翻译： 本发明涉及作为磷酸二酯酶抑制剂西洛他唑及其药学上可接受的盐的衍生物的新化合物。 本发明还提供了包含一种或多种本发明化合物的无热原组合物，以及所公开的化合物和组合物在治疗通过施用磷酸二酯酶抑制剂如西洛他唑治疗的疾病和病症的方法中的用途。 本发明还涉及所公开的化合物和组合物在涉及西洛他唑的分析研究中作为试剂的用途。