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公开(公告)号:US12205277B2
公开(公告)日:2025-01-21
申请号:US17564304
申请日:2021-12-29
Inventor: Yikang Liu , Shanhui Sun , Terrence Chen , Zhang Chen , Xiao Chen
Abstract: Described herein are systems, methods, and instrumentalities associated with image segmentation such as tubular structure segmentation. An artificial neural network is trained to segment tubular structures of interest in a medical scan image based on annotated images of a different type of tubular structures that may have a different contrast and/or appearance from the tubular structures of interest. The training may be conducted in multiple stages during which a segmentation model learned from the annotated images during a first stage may be modified to fit the tubular structures of interest in a second stage. In examples, the tubular structures of interest may include coronary arteries, catheters, guide wires, etc., and the annotated images used for training the artificial neural network may include blood vessels such as retina blood vessels.
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公开(公告)号:US20240420334A1
公开(公告)日:2024-12-19
申请号:US18209704
申请日:2023-06-14
Inventor: Yikang Liu , Zhang Chen , Xiao Chen , Shanhui Sun , Terrence Chen
IPC: G06T7/11
Abstract: An apparatus may obtain a sequence of medical images of a target structure and determine, using a first ANN, a first segmentation and a second segmentation of the target structure based on a first medical image and a second medical image, respectively. The first segmentation may indicate a first plurality of pixels that may belong to the target structure. The second segmentation may indicate a second plurality of pixels that may belong to the target structure. The apparatus may identify, using a second ANN, a first subset of true positive pixels among the first plurality of pixels that may belong to the target structure, and a second subset of true positive pixels among the second plurality of pixels that may belong to the target structure. The apparatus may determine a first refined segmentation and a second refined segmentation of the target structure based on the true positive pixels.
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公开(公告)号:US12141990B2
公开(公告)日:2024-11-12
申请号:US17475534
申请日:2021-09-15
Inventor: Shanhui Sun , Zhang Chen , Xiao Chen , Terrence Chen , Junshen Xu
Abstract: Deep learning based systems, methods, and instrumentalities are described herein for registering images from a same imaging modality and different imaging modalities. Transformation parameters associated with the image registration task are determined using a neural ordinary differential equation (ODE) network that comprises multiple layers, each configured to determine a respective gradient update for the transformation parameters based on a current state of the transformation parameters received by the layer. The gradient updates determined by the multiple ODE layers are then integrated and applied to initial values of the transformation parameters to obtain final parameters for completing the image registration task. The operations of the ODE network may be facilitated by a feature extraction network pre-trained to determine content features shared by the input images. The input images may be resampled into different scales, which are then processed by the ODE network iteratively to improve the efficiency of the ODE operations.
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公开(公告)号:US12141234B2
公开(公告)日:2024-11-12
申请号:US17741323
申请日:2022-05-10
Inventor: Xiao Chen , Yikang Liu , Zhang Chen , Shanhui Sun , Terrence Chen , Daniel Hyungseok Pak
IPC: G06F18/214 , A61B5/00 , G01R33/56 , G06N20/00 , G06T11/00
Abstract: Described herein are systems, methods, and instrumentalities associated with processing complex-valued MRI data using a machine learning (ML) model. The ML model may be learned based on synthetically generated MRI training data and by applying one or more meta-learning techniques. The MRI training data may be generated by adding phase information to real-valued MRI data and/or by converting single-coil MRI data into multi-coil MRI data based on coil sensitivity maps. The meta-learning process may include using portions of the training data to conduct a first round of learning to determine updated model parameters and using remaining portions of the training data to test the updated model parameters. Losses associated with the testing may then be determined and used to refine the model parameters. The ML model learned using these techniques may be adopted for a variety of tasks including, for example, MRI image reconstruction and/or de-noising.
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公开(公告)号:US12040076B2
公开(公告)日:2024-07-16
申请号:US17550594
申请日:2021-12-14
Inventor: Xiao Chen , Shanhui Sun , Terrence Chen
CPC classification number: G16H30/20 , A61B5/0044 , A61B5/055 , G06T7/0014 , G06T7/60 , A61B2576/023 , G06T2207/10088 , G06T2207/20081 , G06T2207/20084 , G06T2207/30048
Abstract: Described herein are systems, methods and instrumentalities associated with automatic assessment of aneurysms. An automatic aneurysm assessment system or apparatus may be configured to obtain, e.g., using a pre-trained artificial neural network, strain values associated one or more locations of a human heart and one or more cardiac phases of the human heart and derive a representation (e.g., a 2D matrix) of the strain values across time and/or space. The system or apparatus may determine, based on the derived representation of the strain values, respective strain patterns associated with the one or more locations of the human heart and further determine whether the one or more locations are aneurysm locations by comparing the automatically determined strain patterns with predetermined normal strain patterns of the heart and determining the presence or risk of aneurysms based on the comparison.
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公开(公告)号:US11992289B2
公开(公告)日:2024-05-28
申请号:US17060988
申请日:2020-10-01
Inventor: Zhang Chen , Xiao Chen , Shanhui Sun , Terrence Chen
IPC: A61B5/00 , G01R33/36 , G01R33/561 , G01R33/563 , G06N3/08 , G06N3/084
CPC classification number: A61B5/0044 , A61B5/7264 , G01R33/3642 , G01R33/5612 , G01R33/5615 , G01R33/56325 , G06N3/08 , G06N3/084
Abstract: A method includes using fully sampled retro cine data to train an algorithm, and applying the trained algorithm to real time MR cine data to yield reconstructed MR images.
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公开(公告)号:US20240144469A1
公开(公告)日:2024-05-02
申请号:US17973982
申请日:2022-10-26
Inventor: Xiao Chen , Shanhui Sun , Terrence Chen , Arun Innanje
IPC: G06T7/00 , G06T7/11 , G06T7/30 , G06V10/764
CPC classification number: G06T7/0012 , G06T7/11 , G06T7/30 , G06V10/764 , G06T2207/10088 , G06T2207/30048
Abstract: Cardiac images such as cardiac magnetic resonance (CMR) images and tissue characterization maps (e.g., T1/T2 maps) may be analyzed automatically using machine learning (ML) techniques, and reports may be generated to summarize the analysis. The ML techniques may include training one or more of an image classification model, a heart segmentation model, or a cardiac pathology detection model to automate the image analysis and/or reporting process. The image classification model may be capable of grouping the cardiac images into different categories, the heart segmentation model may be capable of delineating different anatomical regions of the heart, and the pathology detection model may be capable of detecting a medical abnormality in one or more of the anatomical regions based on tissue patterns or parameters automatically recognized by the detection model. Image registration that compensates for the impact of motions or movements may also be conducted automatically using ML techniques.
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公开(公告)号:US11966454B2
公开(公告)日:2024-04-23
申请号:US17513493
申请日:2021-10-28
Inventor: Zhang Chen , Xiao Chen , Yikang Liu , Terrence Chen , Shanhui Sun
IPC: G06K9/00 , G01R33/56 , G06F18/214 , G06N3/08 , G06T3/40 , G06T5/70 , G06T7/00 , G06T11/00 , G06V10/94 , G16H30/20
CPC classification number: G06F18/2148 , G01R33/5608 , G06N3/08 , G06T3/40 , G06T5/70 , G06T7/0014 , G06T11/008 , G06V10/95 , G16H30/20 , G06T2207/10088 , G06T2207/20081 , G06T2207/20084 , G06T2207/30004
Abstract: A neural network system implements a model for generating an output image based on a received input image. The model is learned through a training process during which parameters associated with the model are adjusted so as to maximize a difference between a first image predicted using first parameter values of the model and a second image predicted using second parameter values of the model, and to minimize a difference between the second image and a ground truth image. During a first iteration of the training process the first image is predicted and during a second iteration the second image is predicted. The first parameter values are obtained during the first iteration by minimizing a difference between the first image and the ground truth image, and the second parameter values are obtained during the second iteration by maximizing the difference between the first image and the second image.
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公开(公告)号:US11965947B2
公开(公告)日:2024-04-23
申请号:US17533276
申请日:2021-11-23
Inventor: Zhang Chen , Shanhui Sun , Xiao Chen , Terrence Chen
CPC classification number: G01R33/5608 , G06N3/045 , G06N3/08
Abstract: In Multiplex MRI image reconstruction, a hardware processor acquires sub-sampled Multiplex MRI data and reconstructs parametric images from the sub-sampled Multiplex MRI data. A machine learning model or deep learning model uses the subsampled Multiplex MRI data as the input and parametric maps calculated from the fully sampled data, or reconstructed fully sample data, as the ground truth. The model learns to reconstruct the parametric maps directly from the subsampled Multiplex MRI data.
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公开(公告)号:US20240087082A1
公开(公告)日:2024-03-14
申请号:US17943724
申请日:2022-09-13
Inventor: Yikang Liu , Shanhui Sun , Terrence Chen
CPC classification number: G06T3/4046 , G06T7/11 , G06F3/0482
Abstract: A magnification system for magnifying an image based on trained neural networks is disclosed. The magnification system receives a first user input associated with a selection of a region of interest (ROI) within an input image of a site and a second user input associated with a first magnification factor of the selected ROI. The first magnification factor is associated with a magnification of the ROI in the input image. The ROI is modified based on an application of a first neural network model on the ROI. The modification of the ROI corresponds to a magnified image that is predicted in accordance with the first magnification factor. A display device is controlled to display the modified ROI.
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