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公开(公告)号：US5695780A
公开(公告)日：1997-12-09
申请号：US468379
申请日：1995-06-06
IPC分类号： C12P9/00 , A61K9/127 , C07F9/09 , C07F9/10 , C07F9/113 , C07F9/653 , C12N15/88 , A61K31/66 , A61K31/675
CPC分类号： C12N15/88 , A61K9/1272 , B82Y5/00 , C07F9/10 , C07F9/113 , C07F9/65324
摘要： A novel class of cationic phospholipids and a novel method for their synthesis are disclosed. The class of phospholipids comprises phosphotriester derivatives of phosphoglycerides and sphingolipids. It has been unexpectedly found that liposomes comprising one or more of these cationic phospholipids are effective in the lipofection of nucleic lacids. These novel phospholipids are particularly attractive because they are extremely cheap and easy to make.
摘要翻译： 公开了一类新型的阳离子磷脂及其合成方法。 磷脂类包括磷酸甘油酯和鞘脂的磷酸三酯衍生物。 意外地发现包含这些阳离子磷脂中的一种或多种的脂质体在核酸的脂质转染中是有效的。 这些新型磷脂是特别有吸引力的，因为它们是非常便宜和容易制造的。
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公开(公告)号：US4875554A
公开(公告)日：1989-10-24
申请号：US238941
申请日：1988-08-31
申请人： Robert C. MacDonald , Elsa Abrego
发明人： Robert C. MacDonald , Elsa Abrego
CPC分类号： B66B1/2458 , B66B2201/102 , B66B2201/211 , B66B2201/226
摘要： A method of assigning hall calls to a plurality of elevator cars (0, 1, N) which biases the assignment process to balance the number of cars serving up and down service directions. Prior to each call assignment update the method determines the number of cars serving each service direction (78, 80, 82). A predetermined relationship (88) between there two numbers is used to determine if up hall calls should be assigned first, or down hall calls (90, 92, 94, 96). The balancing of cars serving the two service directions lowers the average waiting time, and it results in dispersing the cars throughout a building when service subsides, to enable prompt service for newly entered calls without the necessity of moving the cars during periods of low service to be in position for new calls.
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公开(公告)号：US4790412A
公开(公告)日：1988-12-13
申请号：US169210
申请日：1988-03-16
申请人： Robert C. MacDonald , Elsa Abrego
发明人： Robert C. MacDonald , Elsa Abrego
IPC分类号： B66B1/18
CPC分类号： B66B1/2458 , B66B2201/102 , B66B2201/226
摘要： A method of assigning hall calls to a plurality of elevator cars in an ETA strategy in which up hall calls are scanned upwardly and down calls downwardly. A hall call floor at which the scan has stopped for the purpose of assigning or reassigning a hall call at the floor is called a "scan floor". The floor of the advanced position of the car being considered for assignment is called the "AVP floor". In order to favor the clustering of closely adjacent stops in a given car, and thus minimize car bunching, when a car has an intervening stop between the AVP floor and the scan floor, either the travel distance between the AVP floor and the scan floor, or the travel distance from an intervening stop to the scan floor, is used to develop a dynamic bias for the ETA of the associated car. The dynamic or variable bias is inversely proportional to the travel distance, i.e., the number of floors, between the relevant floors.
摘要翻译： 在ETA策略中向多个电梯轿厢分配门厅呼叫的方法，向上和向下扫描向上和向下向上和向下向上扫描向上电梯呼叫。 扫描已停止的门厅呼叫楼层是为了在楼层分配或重新分配门厅呼叫而被称为“扫描楼层”。 正在考虑分配的汽车的先进位置的地板称为“AVP楼层”。 为了有利于在给定轿厢中紧密相邻的停靠点的聚集，并且因此使汽车聚束最小化，当汽车在AVP楼层和扫描楼层之间有中间停止时，AVP楼层与扫描楼层之间的行进距离， 或从中间站到扫描楼的行驶距离用于为相关联的汽车的ETA开发动态偏差。 动态或可变偏压与相关楼层之间的行进距离，即楼层数成反比。
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公开(公告)号：US4532089A
公开(公告)日：1985-07-30
申请号：US570950
申请日：1984-01-14
申请人： Robert C. MacDonald
发明人： Robert C. MacDonald
CPC分类号： A61K9/1277 , Y10S436/829 , Y10T428/2984
摘要： Large size liposomes are produced from small unilamellar vesicles by incorporating a polar compound in an aqueous dispersion of the vesicles, subjecting the dispersion to repeated freeze-thaw cycles, and thereafter dialyzing the vesicles against a hypoosmotic medium. The freeze-thaw cycles aggregate the vesicles and increase their internal concentration of polar compound. During dialysis the vesicles imbibe water, rupture, and form enlarged liposomes.
摘要翻译： 通过在小泡的水性分散体中加入极性化合物，使分散体经受反复冻融循环，然后将透泡液与渗透不良的培养基进行透析，从小单层囊泡中制备大尺寸脂质体。 冻融循环聚集囊泡并增加其极性化合物的内部浓度。 在透析期间，囊泡吸收水分，破裂并形成脂质体扩大。
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