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    Arylmalonamido-1-oxadethiacephalosporins
    21.
    发明授权
    Arylmalonamido-1-oxadethiacephalosporins 失效
    芳基丙二酰胺-1-氧杂硫菌醚

    公开(公告)号：US4138486A

    公开(公告)日：1979-02-06

    申请号：US780183

    申请日：1977-03-22

    申请人： Masayuki Narisada ,  Wataru Nagata

    发明人： Masayuki Narisada ,  Wataru Nagata

    IPC分类号： C07D505/00 ,  A61K31/535 ,  A61K31/5365 ,  A61P31/00 ,  A61P31/04 ,  C07D205/00 ,  C07D265/00 ,  C07D498/02 ,  C07D498/04 ,  C07D505/06 ,  C07D505/18 ,  C07D505/20 ,  A61K27/00 ,  A61K31/555 ,  A61K31/695

    CPC分类号： C07D498/04 ,  A61K31/535 ,  C07D205/00 ,  C07D265/00 ,  C07D505/00

    摘要： Antibacterial 1-oxadethiacephalosporins of the formula: ##STR1## [wherein Ar is ##STR2## (in which Acyl is organic or inorganic acyl); COB.sup.1 and COB.sup.2 each is carboxy or protected carboxy; Het is ##STR3## (in which COB.sup.3 is carboxy or protected carboxy); AND Y is hydrogen or methoxy;And when COB.sup.1, COB.sub.2, and/or COB.sup.3 is carboxy, pharmaceutically acceptable salts thereof are included,But with a proviso that when Y is methoxy, Het is ##STR4## a pharmaceutical or veterinary composition comprising the said 1-oxadethiacephalosporins and pharmaceutical carrier, and a method for treating or preventing human or veterinary infectious diseases comprising administering the said 1-oxadethiacephalosporin.

    摘要翻译： 下式的抗菌1-恶二硫醚孢子：其中Ar是有机或无机酰基;其中Ar是有机或无机酰基; COB1和COB2各自为羧基或保护的羧基; Het是（其中COB 3是羧基或被保护的羧基）; 且Y为氢或甲氧基; 当COB1，COB2和/或COB3为羧基时，包括其药学上可接受的盐，但是当Y为甲氧基时，Het为包含所述1-恶二硫醚类和药物载体的药物或兽用组合物， 以及用于治疗或预防人或兽传染性疾病的方法，包括施用所述1-恶二硫醚类。

    Sample information measuring method and scanning confocal microscope
    22.
    发明授权
    Sample information measuring method and scanning confocal microscope 有权
    样品信息测量方法和扫描共聚焦显微镜

    公开(公告)号：US07205531B2

    公开(公告)日：2007-04-17

    申请号：US10991123

    申请日：2004-11-17

    申请人： Hideo Watanabe ,  Wataru Nagata

    发明人： Hideo Watanabe ,  Wataru Nagata

    IPC分类号： H01J3/14 ,  G02B21/00

    CPC分类号： G02B21/006

    摘要： When irradiating a sample with light from a light source through an object lens, discretely changing a relative position between a beam condensing position of the object lens and the sample in an optical axis direction of the converging beam, obtaining light intensity information from the sample at each relative position, extracting plural pieces of light intensity information from a light intensity information group, estimating a maximum value on a change curve adaptive to the plural pieces of extracted light intensity information and the relative position for the maximum value, and obtaining the estimated maximum value of the light intensity information and relative position as brightness information and height information, these information about the sample can be continuously obtained by discretely performing an iterative operation on the relative position between a beam condensing position of the object lens and the sample in an optical axis direction of the converging beam.

    摘要翻译： 当通过物镜将来自光源的光照射样品时，离散地改变物镜的聚光位置和聚光束的光轴方向上的样品之间的相对位置，从样品中获得光强度信息 每个相对位置，从光强度信息组中提取多个光强度信息，根据多个提取的光强度信息和最大值的相对位置估计适应于变化曲线的最大值，并获得估计的最大值 光强度信息的值和相对位置作为亮度信息和高度信息，关于样本的这些信息可以通过离散地对物镜的光束聚光位置和光学器件的样品之间的相对位置进行迭代操作来连续获得 会聚光束的轴向。

    Semiconductor device inspection system
    23.
    发明授权
    Semiconductor device inspection system 失效
    半导体器件检测系统

    公开(公告)号：US6002792A

    公开(公告)日：1999-12-14

    申请号：US607873

    申请日：1996-02-29

    申请人： Shigehisa Oguri ,  Eiji Inuzuka ,  Kouji Suzuki ,  Wataru Nagata ,  Yasushi Hiruma

    发明人： Shigehisa Oguri ,  Eiji Inuzuka ,  Kouji Suzuki ,  Wataru Nagata ,  Yasushi Hiruma

    IPC分类号： G01N21/95 ,  G01R31/302 ,  G06K9/00

    CPC分类号： G01N21/9501 ,  G01N21/956

    摘要： The present invention relates to an inspection system for transparently taking an image of inside of a semiconductor device to analyze anomalous occurrence. First, image data obtained under infrared ray illumination are converted into a first left-to-right reversed image data in which the obtained image data are reversed left to right and the first left-to-right reversed image data are stored. Next, very weak light emitted from an anomalous portion when the semiconductor device is biased is picked up under no illumination. Then, image data of very weak light is converted into a second left-to-right reversed image data in which the image data of weak light are reversed left to right. The first and second left-to-right image data are superimposed to superimpose the image specifying the anomalous location on an image of chip patterns in the semiconductor device and the superimposed image is displayed. Further, in the infrared-ray epi-irradiation means, an optical filter made of the same material as that of the semiconductor device to be measured is used to form infrared rays for illumination, so that when the back surface of the semiconductor device is irradiated with infrared rays produced by the optical filter, light having a short wavelength which is easily reflected on the surface of the semiconductor device is interrupted and infrared rays having high transmittance against the semiconductor device can be obtined.

    摘要翻译： 本发明涉及一种用于透明地拍摄半导体器件内部的图像以分析异常发生的检查系统。 首先，在红外线照射下获得的图像数据被转换成从左到右反转所获得的图像数据并且存储第一左右颠倒图像数据的第一左右反转图像数据。 接下来，在半导体器件偏置时从异常部分发射的非常弱的光在无照明的情况下被拾取。 然后，非常弱的光的图像数据被转换成其中弱光的图像数据从左到右反转的第二个左至右反转图像数据。 第一和第二左右图像数据被叠加以将指定异常位置的图像叠加在半导体器件中的芯片图案的图像上，并且显示叠加的图像。 此外，在红外线照射装置中，使用与被测量的半导体装置相同的材料制成的滤光器，以形成用于照明的红外线，使得当半导体器件的背面被照射时 利用由滤光器产生的红外线，中断在半导体器件的表面上容易反射的短波长的光，可以获得对半导体器件具有高透射率的红外线。

    Arylmalonamido-1-oxadethiacephalosporins
    25.
    发明授权
    Arylmalonamido-1-oxadethiacephalosporins 失效
    芳基丙二酰胺-1-氧杂硫菌醚

    公开(公告)号：US4323567A

    公开(公告)日：1982-04-06

    申请号：US156872

    申请日：1980-06-05

    申请人： Masayuki Narisada ,  Wataru Nagata

    发明人： Masayuki Narisada ,  Wataru Nagata

    IPC分类号： C07D505/00 ,  A61K31/535 ,  A61K31/5365 ,  A61P31/00 ,  A61P31/04 ,  C07D205/00 ,  C07D265/00 ,  C07D498/02 ,  C07D498/04 ,  C07D505/06 ,  C07D505/18 ,  C07D505/20 ,  C07D413/14 ,  A61K31/41 ,  C07D413/12

    CPC分类号： C07D498/04 ,  A61K31/535 ,  C07D205/00 ,  C07D265/00 ,  C07D505/00

    摘要： Antibacterial 1-oxadethiacephalosporins of the formula: ##STR1## wherein Ar is ##STR2## (in which Acyl is organic or inorganic acyl); COB.sup.1 and COB.sup.2 each is carboxy or protected carboxy;Het is ##STR3## (in which COB.sup.3 is carboxy or protected carboxy); and Y is hydrogen or methoxy;and when COB.sup.1 and COB.sup.2, and/or COB.sup.3 is carboxy, pharmaceutically acceptable salts thereof are included, but with a proviso that when Y is methoxy, Het is ##STR4## a pharmaceutical or veterinary composition comprising the said 1-oxadethiacephalosporins and pharmaceutical carrier, and a method for treating or preventing human or veterinary infectious diseases comprising administering the said 1-oxadethiacephalosporin.Also disclosed are epimers of the compounds of formula (I) wherein the asymmetric carbon of the malonic methine is in the D(R)- or L(S)- configuration. The individual epimers are separable by column chromatography and/or crystallization. The bactericidal activity of the D-epimers is greater than that of the L-epimers or the mixtures of the epimers.

    摘要翻译： 其中Ar是有机或无机酰基的酰基;其中Ar是有机或无机酰基;其中Ar是有机或无机酰基。 COB1和COB2各自为羧基或被保护的羧基; Het是（其中COB 3是羧基或被保护的羧基）; Y为氢或甲氧基; 并且当COB1和COB2和/或COB3为羧基时，包括其药学上可接受的盐，但条件是当Y为甲氧基时，Het为包含所述1-恶二硫醚类和药物载体的药物或兽用组合物， 以及用于治疗或预防人或兽传染性疾病的方法，包括施用所述1-恶二硫醚类。 还公开了式（I）化合物的差向异构体，其中丙二酸次甲基的不对称碳为D（R） - 或L（S） - 构型。 单独的差向异构体可通过柱色谱和/或结晶分离。 D-差向异构体的杀菌活性大于L-差向异构体或差向异构体的混合物的杀菌活性。

    Cephalosporin analogues
    28.
    发明授权
    Cephalosporin analogues 失效
    头孢菌素类似物

    公开(公告)号：US4197402A

    公开(公告)日：1980-04-08

    申请号：US15180

    申请日：1979-02-26

    申请人： Yoshio Hamashima ,  Wataru Nagata

    发明人： Yoshio Hamashima ,  Wataru Nagata

    IPC分类号： C07D505/00 ,  C07D498/00

    CPC分类号： C07D505/00

    摘要： 1-Oxa-cephalosporin analogues of the formula: ##STR1## [wherein X is 3-thienylmalonyl, phenylmalonyl, 4-hydroxyphenylmalonyl, or 2-fluoro-4-hydroxyphenylmalonyl;Y is hydrogen or methoxy; andR is hydrogen, alkali metal, or alkaline earth metal]and the preparation thereof.

    摘要翻译： 具有下式的1-氧杂 - 头孢菌素类似物：其中X是3-噻吩基丙二酰基，苯基丙二酸，4-羟基苯基丙二酸或2-氟-4-羟基苯基丙二酰基; Y是氢或甲氧基; 和R是氢，碱金属或碱土金属]及其制备。

    Haloarylmalonamidooxacephalosporins
    29.
    发明授权
    Haloarylmalonamidooxacephalosporins 失效
    卤代芳基丙酰胺氧基头孢菌素

    公开(公告)号：US4183928A

    公开(公告)日：1980-01-15

    申请号：US900235

    申请日：1978-04-26

    申请人： Yoshio Hamashima ,  Masayuki Narisada ,  Sadao Hayashi ,  Wataru Nagata

    发明人： Yoshio Hamashima ,  Masayuki Narisada ,  Sadao Hayashi ,  Wataru Nagata

    IPC分类号： C07D505/06 ,  A61K31/5365 ,  A61P31/00 ,  C07C59/56 ,  C07D505/00 ,  C07D505/20 ,  C07D413/02 ,  A61K31/395 ,  A61K31/535

    CPC分类号： C07C59/56 ,  C07D505/00

    摘要： Antibacterial haloarylmalonamido-1-dethia-1-oxacephalosporins of the following formula: ##STR1## wherein Ar is ##STR2## (in which Hal and Hal' each is halogen and RO is hydroxy or protected hydroxy);COA and COB each is carboxy or protected carboxy including a pharmaceutically acceptable salt group;and Het is 1-lower alkyl-5-tetrazolyl, 1,3,4-thiadiazol-2-yl or 5-lower alkyl-1,3,4-thiadiazol-2-yl,a pharmaceutical or veterinary composition comprising the said haloarylmalonamido-1-dethia-1-oxacephalosporin and pharmaceutical carrier, and a method for treating or preventing human or veterinary infectious diseases comprising administering an effective amount of the said antibacterial compound.

    摘要翻译： 其中Ar是卤素，Hal和Hal各自为卤素，RO为羟基或被保护的羟基）的抗菌卤代芳基丙二酰胺-1-脱氧-1-氧杂七环素：其中Ar为< ; COA和COB各自为羧基或受保护的羧基，包括药学上可接受的盐基; 和Het是1-低级烷基-5-四唑基，1,3,4-噻二唑-2-基或5-低级烷基-1,3,4-噻二唑-2-基，其包含所述卤代芳基丙二酰胺 -1-脱氢-1-氧杂环孢菌素和药物载体，以及治疗或预防人或兽传感疾病的方法，包括给予有效量的所述抗菌化合物。