公开(公告)号：US20060265043A1

公开(公告)日：2006-11-23

申请号：US11388355

申请日：2006-03-24

Applicant: Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy ,  Jessica Chiu ,  Mina Chow ,  Eugene Michal ,  Charles Claude ,  William Webler

Inventor： Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy ,  Jessica Chiu ,  Mina Chow ,  Eugene Michal ,  Charles Claude ,  William Webler

IPC: A61F2/06

CPC classification number: A61F2/07 ,  A61B5/02007 ,  A61B2017/22077 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2/958 ,  A61F2002/077 ,  A61F2220/0058 ,  A61F2250/0067 ,  A61M1/3613 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1056 ,  A61M2025/107 ,  A61M2025/1086 ,  A61M2025/1095

Abstract: Various apparatuses and methods are described to treat vulnerable plaque with the use of combination drug therapy. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plaque. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.

Abstract translation: 描述了使用组合药物治疗来治疗易损斑块的各种装置和方法。 在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。 药物递送装置被配置为递送治疗或生物活性剂以稳定易损斑块。 在另一个实施方案中，药物洗脱支架与在加压逆行灌注中递送药物的第二装置一起递送和展开。 另一个实施例使用独特形状的气囊来展开支架，同时利用药物输注针将药物通过空心导丝将药物注入血管壁。

公开(公告)号：US06793960B1

公开(公告)日：2004-09-21

申请号：US10005251

申请日：2001-12-03

Applicant: Eugene T. Michal ,  Murthy Simhambhatla ,  Charles D. Claude

Inventor： Eugene T. Michal ,  Murthy Simhambhatla ,  Charles D. Claude

IPC: B05D300

CPC classification number: C08J7/123 ,  A61L29/085 ,  A61L31/10 ,  A61M25/0009 ,  A61M25/0014 ,  A61M25/1027 ,  A61M25/1029 ,  A61M25/1034 ,  B05D1/62 ,  Y10S623/926 ,  Y10T428/26 ,  Y10T428/263 ,  Y10T428/265 ,  Y10T428/31504 ,  Y10T428/3154 ,  Y10T428/31544 ,  Y10T428/31551 ,  Y10T428/31663 ,  Y10T428/31721 ,  Y10T428/31855

Abstract: A medical device comprising a substrate having a plasma polymerized functionally bonded to at least a portion of the substrate. A superoxide dismutase mimic agent having a complimentary functional group to the plasma polymerized functionality is bonded to the portion of the substrate by bonding to the plasma polymerized functionality.

Abstract translation: 一种医疗装置，包括具有等离子体的基板，所述等离子体与所述基板的至少一部分功能性结合。 通过与等离子体聚合官能团的结合，具有与等离子体聚合官能团互补的官能团的超氧化物歧化酶模拟剂结合到基底的该部分。