公开(公告)号：US08308683B2

公开(公告)日：2012-11-13

申请号：US12768431

申请日：2010-04-27

申请人： Michael J. Leonard ,  Binh T. Nguyen ,  William Webler

发明人： Michael J. Leonard ,  Binh T. Nguyen ,  William Webler

IPC分类号： A61M31/00

CPC分类号： A61M25/1002 ,  A61M25/0668 ,  A61M25/104 ,  A61M2025/0004 ,  A61M2025/0024 ,  A61M2025/0037 ,  A61M2025/0039 ,  A61M2025/0096 ,  A61M2025/0681 ,  A61M2025/105

摘要： An agent delivery catheter configured to deliver an agent to an inner surface of a patient's body lumen wall by forming an array of cells defining agent containment chambers at multiple locations along the catheter's shaft, while minimizing ischemic conditions during the procedure.

摘要翻译： 一种药剂递送导管，配置成通过在导管的轴的多个位置处形成限定药剂容纳室的细胞阵列，同时使手术过程中的缺血状况最小化，将药剂递送到患者体腔壁的内表面。

公开(公告)号：US20050182387A1

公开(公告)日：2005-08-18

申请号：US10778270

申请日：2004-02-13

申请人： William Webler

发明人： William Webler

IPC分类号： A61M25/06 ,  A61M25/00

CPC分类号： A61M25/0668

摘要： A peel-away shaft for a guiding catheter includes a shaft wall defining an open lumen of the catheter shaft. A peel-away region is defined over at least a partial length of the catheter shaft. A braid substantially encompasses the open lumen. The braid includes a region of discontinuity extending along the peel-away region. The region of discontinuity of the braid reduces the tear resistance of the shaft wall along the peel-away region.

摘要翻译： 用于引导导管的剥离轴包括限定导管轴的开口腔的轴壁。 剥离区域限定在导管轴的至少一部分长度上。 编织物基本上包围开口腔。 编织物包括沿剥离区域延伸的不连续区域。 编织物的不连续区域降低了沿着剥离区域的轴壁的抗撕裂性。

公开(公告)号：US20070167801A1

公开(公告)日：2007-07-19

申请号：US11293559

申请日：2005-12-02

申请人： William Webler ,  Mina Chow

发明人： William Webler ,  Mina Chow

IPC分类号： A61B8/14

CPC分类号： G06T19/00 ,  A61B8/4245 ,  A61B8/445 ,  A61B8/483 ,  A61B17/3478 ,  A61B2017/00247 ,  A61B2017/00455 ,  A61B2018/00392 ,  G06F19/00 ,  G06T7/32 ,  G06T7/38 ,  G06T2207/30004 ,  G06T2210/41 ,  G16H50/50

摘要： Methods and apparatuses for the image guidance and documentation of medical procedures. One embodiment includes combining small field of view images into a recorded image of with a large field of view and aligning the small field of view real time image with the recorded image through correlation of imaging data. A location and orientation determination system may be used to track the imaging system and provide a starting set of image alignment parameters and/or provide change updates to a set of image alignment parameters, which is then further improved through correlating imaging data. The recorded image may be selected according to real time measurement of a cardiac parameter during an image guided cardiac procedure. Image manipulations planned based on the recorded image can be stored and applied to the real time information. The position of the medical device may be determined and recorded through manipulating a cursor in a 3-D image space shown in two non-parallel views.

摘要翻译： 图像指导和医疗程序记录的方法和设备。 一个实施例包括将小视野图像组合成具有大视野的记录图像，并通过成像数据的相关将小视野实时图像与记录图像对准。 位置和方向确定系统可以用于跟踪成像系统并提供一组图像对准参数和/或向一组图像对准参数提供改变更新，然后通过相关成像数据进一步改进。 记录图像可以在图像引导的心脏手术期间根据心脏参数的实时测量来选择。 基于记录图像计划的图像处理可以被存储并应用于实时信息。 可以通过在两个非平行视图中示出的3-D图像空间中操纵光标来确定和记录医疗装置的位置。

公开(公告)号：US20070142818A1

公开(公告)日：2007-06-21

申请号：US11313477

申请日：2005-12-20

申请人： William Webler ,  August Yambao

发明人： William Webler ,  August Yambao

IPC分类号： A61M31/00

CPC分类号： A61B17/12022 ,  A61B17/1204 ,  A61M25/0021 ,  A61M25/1002 ,  A61M25/10182 ,  A61M25/10188 ,  A61M25/1027 ,  A61M2025/1052

摘要： A controlled volume inflation-deflation device to inflate a balloon to occlude a blood vessel by dialing a knob that locks at rotational positions to locate a plunger at equally spaced locations within a syringe of the inflation-deflation device. The inflation-deflation device includes a releasable latch to lock the proximal and distal housings together to hold the plunger forward for occlusion, and to separate and hold the proximal and distal housings to retract the plunger for perfusion. When the inflation-deflation device is returned to the-latched position, the balloon is re-inflated to its previous occlusive diameter. Also, an extension tube made of a lower modulus outer material co-extruded over and miscible with a higher modulus inner material may be used to produce a suitably low compliance extension tube for the inflation-deflation device. The balloon may have tapered ends and a cylindrical center portion so that it increases by more equal increments in outer diameter in response to incremental equal increases in inflation volume.

摘要翻译： 一种受控体积的充气 - 放气装置，用于通过拨打锁定在旋转位置处的手柄来使气囊膨胀以封闭血管，以将柱塞定位在充气 - 放气装置的注射器内的等间隔位置处。 充气 - 放气装置包括可释放的闩锁，以将近端和远端壳体锁定在一起以将柱塞保持在前方用于闭塞，并且分离并保持近端和远端壳体以缩回柱塞用于灌注。 当充气 - 放气装置返回到闩锁位置时，将气囊重新充气到其先前的闭塞直径。 此外，可以使用由较高模量的内部材料共挤出并可与较高模量的内部材料混合的由较低模量的外部材料制成的延伸管，以产生用于充气 - 收缩装置的合适的柔顺性延伸管。 球囊可以具有锥形端部和圆柱形中心部分，使得响应于增加的充气体积的相等增加，其在外径中增加更多相等的增量。

公开(公告)号：US20070129752A1

公开(公告)日：2007-06-07

申请号：US11295419

申请日：2005-12-06

申请人： William Webler ,  Gary Hague ,  Frank Manning

发明人： William Webler ,  Gary Hague ,  Frank Manning

IPC分类号： A61M29/00

CPC分类号： A61M25/10 ,  A61B2017/22067 ,  A61F2/013 ,  A61F2002/018 ,  A61F2230/0006 ,  A61F2230/0071 ,  A61F2230/0076 ,  A61M25/0029 ,  A61M25/0032 ,  A61M2025/0057 ,  A61M2025/105 ,  A61M2025/1052 ,  A61M2025/1086

摘要： Catheter or guidewire mounted automatic vessel occlusion and fluid dispersion devices that expand to occlude or partially occlude a vessel when a fluid is flowing in the catheter or guidewire, and that automatically collapse when fluid flow is stopped. Each occlusion device has an elastic skeleton covered with a flexible cover coupled thereto and may have a hole(s) or openings in its distal or proximal end thereof to allow controlled flow through the desired end of the occlusion device. The fluid may be a flush fluid for enabling or improving the performance of imaging devices and image enhancing fluids, of treatment fluids for localized treatment of a vessel or tissues in communication with the vessel and/or of the transmission of energy to the vessel wall and adjacent tissues. Various embodiments are disclosed, including embodiments having provisions for the rapid expansion and collapse of the occlusion device or alternately, for the rapid expansion of the device, followed by much slower collapse of the device.

摘要翻译： 导管或导丝安装的自动血管闭塞和流体分散装置，其在流体在导管或导丝中流动时膨胀以封闭或部分闭塞血管，并且当流体流停止时自动塌陷。 每个闭塞装置具有被耦合到其上的柔性盖子覆盖的弹性框架，并且在其远端或近端具有孔或开口，以允许受阻流过穿过闭塞装置的期望端部。 流体可以是冲洗流体，用于实现或改善成像装置和图像增强流体的性能，用于处理流体用于与容器连通的容器或组织的局部处理和/或向容器壁传递能量， 相邻组织。 公开了各种实施例，包括具有用于闭塞装置的快速膨胀和塌缩的装置的替代实施例，或者替代地，用于装置的快速膨胀，其后是装置的较慢的崩溃。

公开(公告)号：US20070055142A1

公开(公告)日：2007-03-08

申请号：US10390065

申请日：2003-03-14

申请人： William Webler

发明人： William Webler

IPC分类号： A61B5/05

CPC分类号： A61B5/06 ,  A61B5/055 ,  A61B5/061 ,  A61B5/062 ,  A61B5/7285 ,  A61B6/503 ,  A61B6/507 ,  A61B6/541 ,  A61B8/543

摘要： Methods and apparatuses for guiding the positioning of a device with a position tracking sensor and pre-recorded images. At least one embodiment of the present invention uses pre-recorded time-dependent images (e.g., anatomical images or diagnostic images) to guide the positioning of a medical instrument (e.g., catheter tips) using real time position tracking during diagnostic and/or therapeutic operations with pre-recorded images. In one embodiment of the present invention, predetermined spatial relations are used to determine the position of a tracked medical instrument relative to the pre-recorded images.

摘要翻译： 用于引导具有位置跟踪传感器和预先记录的图像的装置的定位的方法和装置。 本发明的至少一个实施例使用预先记录的时间依赖性图像（例如，解剖图像或诊断图像）来在诊断和/或治疗期间使用实时位置跟踪来引导医疗器械（例如导管尖端）的定位 具有预录图像的操作。 在本发明的一个实施例中，使用预定的空间关系来确定跟踪的医疗器械相对于预先记录的图像的位置。

公开(公告)号：US20060223176A1

公开(公告)日：2006-10-05

申请号：US11097022

申请日：2005-03-31

申请人： Evgenia Mandrusov ,  Albert Chin ,  William Webler ,  Yan Shen ,  Robert Ainsworth ,  Eugene Michel

发明人： Evgenia Mandrusov ,  Albert Chin ,  William Webler ,  Yan Shen ,  Robert Ainsworth ,  Eugene Michel

IPC分类号： C12N5/00

CPC分类号： A61B17/3472 ,  A61B1/015 ,  A61B1/313 ,  A61B2017/00969 ,  A61B2217/005 ,  A61K35/28 ,  A61K2035/124 ,  A61M5/00 ,  A61M2202/10 ,  A61M2210/02 ,  A61M2210/125

摘要： Numerous embodiments of a system and method for treating cardiac tissue are described. In one embodiment, bone marrow cells are extracted from a patient. The cells are then processed to isolate mononuclear cells, which can then be delivered back near the cardiac tissue of the patient.

摘要翻译： 描述了用于治疗心脏组织的系统和方法的许多实施例。 在一个实施方案中，从患者中提取骨髓细胞。 然后处理细胞以分离单核细胞，其然后可以在患者的心脏组织附近被递送回来。

公开(公告)号：US20060149186A1

公开(公告)日：2006-07-06

申请号：US11028350

申请日：2004-12-30

申请人： Ken Wantink ,  William Webler ,  Jeong Lee

发明人： Ken Wantink ,  William Webler ,  Jeong Lee

IPC分类号： A61M29/00

CPC分类号： A61M25/10 ,  A61M25/0029 ,  A61M2025/004 ,  A61M2025/105

摘要： An infusion catheter having a distal shaft with an infusion tube extending from a proximal end to a distal end of the distal shaft, and a proximal cannula with an inner dimension and a distal end attached to a proximal end of the distal shaft to define an opening between the inner diameter of the infusion tube and the inner dimension of the proximal cannula. Also, a guidewire tube disposed within the inner dimension and the distal shaft and extending from the proximal end of the proximal cannula to the distal end of the distal shaft. The inner diameter of the infusion tube, the opening, the exterior dimension of the guidewire tube and the inner dimension cooperate and define sufficient cross sectional sizes to allow a treatment agent to be infused between the proximal end of the proximal cannula and the region of interest.

摘要翻译： 输液导管，其具有远侧轴，所述远端轴具有从所述远端轴的近端延伸到远端的输注管，以及近端插管，其内部尺寸和远端附接到所述远端轴的近端以限定开口 在输注管的内径和近侧插管的内部尺寸之间。 而且，导丝管设置在内部尺寸和远端轴内并且从近侧插管的近端延伸到远侧轴的远端。 输注管的内径，开口，导丝管的外部尺寸和内部尺寸协调并限定足够的横截面尺寸，以允许治疗剂注入近端插管的近端和感兴趣区域之间 。

公开(公告)号：US20080041516A1

公开(公告)日：2008-02-21

申请号：US11923258

申请日：2007-10-24

申请人： Jessica Chiu ,  Gregory Chan ,  Gabriel Asongwe ,  Robert Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Bei ,  William Webler ,  Stephen Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark Bly ,  Thomas Hatten

发明人： Jessica Chiu ,  Gregory Chan ,  Gabriel Asongwe ,  Robert Esselstein ,  Douglas Gesswein ,  Srinivasan Sridharan ,  Nianjiong Bei ,  William Webler ,  Stephen Schaible ,  Mina Chow ,  Yan Shen ,  Hongzhi Bai ,  Mark Bly ,  Thomas Hatten

IPC分类号： B29C53/60

CPC分类号： A61M25/10 ,  A61M25/1002 ,  A61M2025/1052

摘要： Embodiments include an infusion-occlusion system having a delivery catheter, a guide catheter adapted to receive the delivery catheter, and a guidewire with an occlusion device adapted to be received within the guide catheter. The guide catheter of the catheter kit may be provided with an occlusion device at the distal end of the guide catheter. The delivery catheter may have an accessory lumen, coaxial or co-linear lumen, a supporting mandrel, or an occlusion device at its distal end. Moreover, according to some embodiments, occlusion devices may be a single material or a composite balloon having an inner liner and an outer layer of different materials, a high compliance low pressure balloon, or a filter device that restricts particles from passing through but does not restrict fluid, such as blood. An inflation device with a large volume and low volume syringe can be used to inflate the balloon.

摘要翻译： 实施例包括具有输送导管的输液阻塞系统，适于接收输送导管的引导导管，以及具有适于容纳在引导导管内的闭塞装置的导丝。 导管套件的引导导管可以在引导导管的远端处设置有闭塞装置。 输送导管可以具有附件腔，同轴或共线腔，支撑心轴或其远端处的闭塞装置。 此外，根据一些实施例，闭塞装置可以是具有内衬和不同材料外层的单一材料或复合球囊，高顺应性低压气球或限制颗粒通过但不限制的过滤装置 限制流体，如血液。 可以使用具有大体积和低体积注射器的充气装置来使气囊膨胀。

公开(公告)号：US20060265043A1

公开(公告)日：2006-11-23

申请号：US11388355

申请日：2006-03-24

申请人： Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy ,  Jessica Chiu ,  Mina Chow ,  Eugene Michal ,  Charles Claude ,  William Webler

发明人： Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy ,  Jessica Chiu ,  Mina Chow ,  Eugene Michal ,  Charles Claude ,  William Webler

IPC分类号： A61F2/06

CPC分类号： A61F2/07 ,  A61B5/02007 ,  A61B2017/22077 ,  A61F2/82 ,  A61F2/86 ,  A61F2/90 ,  A61F2/958 ,  A61F2002/077 ,  A61F2220/0058 ,  A61F2250/0067 ,  A61M1/3613 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1056 ,  A61M2025/107 ,  A61M2025/1086 ,  A61M2025/1095

摘要： Various apparatuses and methods are described to treat vulnerable plaque with the use of combination drug therapy. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a therapeutic or biologically active agent to stabilize a vulnerable plaque. In another embodiment, a drug eluting stent is delivered and deployed in conjunction with a second apparatus that delivers drug in pressurized retrograde perfusion. Still another embodiment uses a uniquely shaped balloon to deploy a stent while utilizing a drug infusion needle to inject drug into the vessel wall through a hollow guide wire.

摘要翻译： 描述了使用组合药物治疗来治疗易损斑块的各种装置和方法。 在一个实施例中，该装置具有适于插入体腔中的细长导管体，其中药物递送装置附接在细长体的远侧部分附近。 药物递送装置被配置为递送治疗或生物活性剂以稳定易损斑块。 在另一个实施方案中，药物洗脱支架与在加压逆行灌注中递送药物的第二装置一起递送和展开。 另一个实施例使用独特形状的气囊来展开支架，同时利用药物输注针将药物通过空心导丝将药物注入血管壁。