公开(公告)号：US20120095234A1

公开(公告)日：2012-04-19

申请号：US13330959

申请日：2011-12-20

申请人： Franck Raeppel ,  Ljubomir Isakovic ,  Stephen William Claridge ,  Michael Mannion ,  Lijie Zhan ,  Marie-Claude Granger ,  Arkadii Vaisburg ,  Miguel Nantel

发明人： Franck Raeppel ,  Ljubomir Isakovic ,  Stephen William Claridge ,  Michael Mannion ,  Lijie Zhan ,  Marie-Claude Granger ,  Arkadii Vaisburg ,  Miguel Nantel

IPC分类号： C07D495/04 ,  C07D213/38

CPC分类号： C07D495/04 ,  C07D213/38 ,  C07D213/51 ,  C07D213/61

摘要： This invention relates to processes and intermediates for manufacturing fused heterocyclic-type kinase inhibitor compounds, such as thienopyridine-based compounds, and to processes and intermediates for preparing intermediates that are useful in the manufacture of fused heterocyclic-type kinase inhibitor compounds, such as thienopyridine-based compounds, particularly at an industrial level.

摘要翻译： 本发明涉及用于制备稠合杂环型激酶抑制剂化合物（例如噻吩并吡啶类化合物）的方法和中间体，以及用于制备可用于制备稠合杂环型激酶抑制剂化合物如噻吩并吡啶的中间体的方法和中间体 的化合物，特别是在工业水平。

公开(公告)号：US20110077240A1

公开(公告)日：2011-03-31

申请号：US12964289

申请日：2010-12-09

申请人： Michael Mannion ,  Stéphane Raeppel ,  Stephen William Claridge ,  Frédéric Gaudette ,  Lijie Zhan ,  Ljubomir Isakovic ,  Oscar Mario Saavedra ,  Tetsuyuki Uno ,  Masashi Kishida ,  Arkadii Vaisburg

发明人： Michael Mannion ,  Stéphane Raeppel ,  Stephen William Claridge ,  Frédéric Gaudette ,  Lijie Zhan ,  Ljubomir Isakovic ,  Oscar Mario Saavedra ,  Tetsuyuki Uno ,  Masashi Kishida ,  Arkadii Vaisburg

IPC分类号： A61K31/541 ,  C07D495/04 ,  A61K31/4365 ,  A61P27/02

CPC分类号： C07D495/04 ,  C07F9/6561

摘要： This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling. The invention also provides compounds, compositions and methods for treating cell proliferative diseases and conditions and opthalmological diseases, disorders and conditions.

摘要翻译： 本发明涉及抑制蛋白酪氨酸激酶活性的化合物。 特别地，本发明涉及抑制生长因子受体的蛋白酪氨酸激酶活性的化合物，导致受体信号传导的抑制，例如VEGF受体信号传导的抑制。 本发明还提供了用于治疗细胞增殖性疾病和病症以及眼科疾病，病症和病症的化合物，组合物和方法。

公开(公告)号：US20090286984A1

公开(公告)日：2009-11-19

申请号：US12231297

申请日：2008-08-29

申请人： Franck Raeppel ,  Ljubomir Isakovic ,  Stephen William Claridge ,  Michael Mannion ,  Lijie Zhan ,  Marie-Claude Granger ,  Arkadii Vaisburg ,  Miguel Nantel

发明人： Franck Raeppel ,  Ljubomir Isakovic ,  Stephen William Claridge ,  Michael Mannion ,  Lijie Zhan ,  Marie-Claude Granger ,  Arkadii Vaisburg ,  Miguel Nantel

IPC分类号： C07D495/04

CPC分类号： C07D495/04 ,  C07D213/38 ,  C07D213/51 ,  C07D213/61

摘要： This invention relates to processes and intermediates for manufacturing fused heterocyclic-type kinase inhibitor compounds, such as thienopyridine-based compounds, and to processes and intermediates for preparing intermediates that are useful in the manufacture of fused heterocyclic-type kinase inhibitor compounds, such as thienopyridine-based compounds, particularly at an industrial level.

摘要翻译： 本发明涉及用于制备稠合杂环型激酶抑制剂化合物（例如噻吩并吡啶类化合物）的方法和中间体，以及用于制备可用于制备稠合杂环型激酶抑制剂化合物如噻吩并吡啶的中间体的方法和中间体 的化合物，特别是在工业水平。

公开(公告)号：US08907091B2

公开(公告)日：2014-12-09

申请号：US12231297

申请日：2008-08-29

申请人： Franck Raeppel ,  Ljubomir Isakovic ,  Stephen William Claridge ,  Michael Mannion ,  Lijie Zhan ,  Marie-Claude Granger ,  Arkadii Vaisburg ,  Miguel Nantel

发明人： Franck Raeppel ,  Ljubomir Isakovic ,  Stephen William Claridge ,  Michael Mannion ,  Lijie Zhan ,  Marie-Claude Granger ,  Arkadii Vaisburg ,  Miguel Nantel

IPC分类号： C07D513/04 ,  C07D213/51 ,  C07D495/04 ,  C07D213/61 ,  C07D213/38

CPC分类号： C07D495/04 ,  C07D213/38 ,  C07D213/51 ,  C07D213/61

摘要： This invention relates to processes and intermediates for manufacturing fused heterocyclic-type kinase inhibitor compounds, such as thienopyridine-based compounds, and to processes and intermediates for preparing intermediates that are useful in the manufacture of fused heterocyclic-type kinase inhibitor compounds, such as thienopyridine-based compounds, particularly at an industrial level.

摘要翻译： 本发明涉及用于制备稠合杂环型激酶抑制剂化合物（例如噻吩并吡啶类化合物）的方法和中间体，以及用于制备可用于制备稠合杂环型激酶抑制剂化合物如噻吩并吡啶的中间体的方法和中间体 的化合物，特别是在工业水平。

公开(公告)号：US08569503B2

公开(公告)日：2013-10-29

申请号：US13330959

申请日：2011-12-20

申请人： Ljubomir Isakovic

发明人： Ljubomir Isakovic

IPC分类号： C07D513/04

CPC分类号： C07D495/04 ,  C07D213/38 ,  C07D213/51 ,  C07D213/61

摘要： This invention relates to processes and intermediates for manufacturing fused heterocyclic-type kinase inhibitor compounds, such as thienopyridine-based compounds, and to processes and intermediates for preparing intermediates that are useful in the manufacture of fused heterocyclic-type kinase inhibitor compounds, such as thienopyridine-based compounds, particularly at an industrial level.