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公开(公告)号:US08729268B2
公开(公告)日:2014-05-20
申请号:US12920676
申请日:2009-02-27
申请人: Michael Mannion , Stéphane Raeppel , Stephen William Claridge , Frédéric Gaudette , Lijie Zhan , Ljubomir Isakovic , Oscar Mario Saavedra , Tetsuyuki Uno , Masashi Kishida , Arkadii Vaisburg
发明人: Michael Mannion , Stéphane Raeppel , Stephen William Claridge , Frédéric Gaudette , Lijie Zhan , Ljubomir Isakovic , Oscar Mario Saavedra , Tetsuyuki Uno , Masashi Kishida , Arkadii Vaisburg
IPC分类号: A61K31/4365 , C07D513/04
CPC分类号: C07D495/04 , C07F9/6561
摘要: This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling. The invention also provides compounds, compositions and methods for treating cell proliferative diseases and conditions and opthalmological diseases, disorders and conditions.
摘要翻译: 本发明涉及抑制蛋白酪氨酸激酶活性的化合物。 特别地,本发明涉及抑制生长因子受体的蛋白酪氨酸激酶活性的化合物,导致受体信号传导的抑制,例如VEGF受体信号传导的抑制。 本发明还提供了用于治疗细胞增殖性疾病和病症以及眼科疾病,病症和病症的化合物,组合物和方法。
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公开(公告)号:US20110077240A1
公开(公告)日:2011-03-31
申请号:US12964289
申请日:2010-12-09
申请人: Michael Mannion , Stéphane Raeppel , Stephen William Claridge , Frédéric Gaudette , Lijie Zhan , Ljubomir Isakovic , Oscar Mario Saavedra , Tetsuyuki Uno , Masashi Kishida , Arkadii Vaisburg
发明人: Michael Mannion , Stéphane Raeppel , Stephen William Claridge , Frédéric Gaudette , Lijie Zhan , Ljubomir Isakovic , Oscar Mario Saavedra , Tetsuyuki Uno , Masashi Kishida , Arkadii Vaisburg
IPC分类号: A61K31/541 , C07D495/04 , A61K31/4365 , A61P27/02
CPC分类号: C07D495/04 , C07F9/6561
摘要: This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling. The invention also provides compounds, compositions and methods for treating cell proliferative diseases and conditions and opthalmological diseases, disorders and conditions.
摘要翻译: 本发明涉及抑制蛋白酪氨酸激酶活性的化合物。 特别地,本发明涉及抑制生长因子受体的蛋白酪氨酸激酶活性的化合物,导致受体信号传导的抑制,例如VEGF受体信号传导的抑制。 本发明还提供了用于治疗细胞增殖性疾病和病症以及眼科疾病,病症和病症的化合物,组合物和方法。
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公开(公告)号:US08404846B2
公开(公告)日:2013-03-26
申请号:US12200939
申请日:2008-08-29
申请人: Stephen William Claridge , Ljubomir Isakovic , Michael Mannion , Stéphane Raeppel , Oscar Mario Saavedra , Frédéric Gaudette , Lijie Zhan , Arkadii Vaisburg
发明人: Stephen William Claridge , Ljubomir Isakovic , Michael Mannion , Stéphane Raeppel , Oscar Mario Saavedra , Frédéric Gaudette , Lijie Zhan , Arkadii Vaisburg
IPC分类号: C07D513/02
CPC分类号: C07D495/04
摘要: This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling and HGF receptor signaling. More particularly, the invention relates to compounds, compositions and methods for the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
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公开(公告)号:US08906852B2
公开(公告)日:2014-12-09
申请号:US13082923
申请日:2011-04-08
申请人: Stéphane Raeppel , Franck Raeppel , Stephen William Claridge , Lijie Zhan , Frédéric Gaudette , Michael Mannion , Norifumi Sato , Yohei Yuki , Masashi Kishida , Arkadii Vaisburg
发明人: Stéphane Raeppel , Franck Raeppel , Stephen William Claridge , Lijie Zhan , Frédéric Gaudette , Michael Mannion , Norifumi Sato , Yohei Yuki , Masashi Kishida , Arkadii Vaisburg
IPC分类号: A61K38/00 , C07K14/47 , A61P35/00 , C07K14/515 , A61P9/10 , A61P27/02 , A61K38/05 , A01N57/00 , A61K31/675 , A61K31/535 , A61K31/497 , A01N43/42 , A61K31/44 , C07F9/06 , C07F9/28 , C07D513/02 , C07D495/04 , C07F9/6561 , C07D519/00
CPC分类号: C07D495/04 , A61K38/005 , C07D519/00 , C07F9/6561 , C07K5/06
摘要: This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling. The invention also provides compounds, compositions and methods for treating cell proliferative diseases and conditions and ophthalmic diseases, disorders and conditions.
摘要翻译: 本发明涉及抑制蛋白酪氨酸激酶活性的化合物。 特别地,本发明涉及抑制生长因子受体的蛋白酪氨酸激酶活性的化合物,导致受体信号传导的抑制,例如VEGF受体信号传导的抑制。 本发明还提供了用于治疗细胞增殖性疾病和病症以及眼科疾病,病症和病症的化合物,组合物和方法。
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公开(公告)号:US08455484B2
公开(公告)日:2013-06-04
申请号:US13082944
申请日:2011-04-08
申请人: Stéphane Raeppel , Lijie Zhan , Stephen William Claridge , Franck Raeppel , Frédéric Gaudette , Arkadii Vaisburg
发明人: Stéphane Raeppel , Lijie Zhan , Stephen William Claridge , Franck Raeppel , Frédéric Gaudette , Arkadii Vaisburg
IPC分类号: A61K31/5377 , A61K31/496 , A61K31/4365 , C07D413/14 , C07D471/04
CPC分类号: C07D495/04 , A61K38/005 , C07D519/00 , C07F9/6561 , C07K5/06
摘要: The invention provides new compounds and compositions thereof. The invention also provides methods for treating ophthalmic diseases, disorders and conditions.
摘要翻译: 本发明提供了新的化合物及其组合物。 本发明还提供了治疗眼科疾病,病症和病症的方法。
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