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21.发明申请公开(公告)号：US20100047188A1
公开(公告)日：2010-02-25
申请号：US12534476
申请日：2009-08-03
申请人： Ekambar Kandimalla , Mallikarjuna Putta , Lakshmi Bhagat , Daqing Wang , Dong Yu , Sudhir Agrawal
发明人： Ekambar Kandimalla , Mallikarjuna Putta , Lakshmi Bhagat , Daqing Wang , Dong Yu , Sudhir Agrawal
IPC分类号： A61K9/12 , C07H21/04 , A61K31/7088 , A61K39/395 , A61K38/00 , A61K39/00
CPC分类号： A61K31/7125 , A61K9/127 , C12N15/1138 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/341 , Y02A50/401 , Y02A50/411 , Y02A50/414 , C12N2310/3521
摘要： Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR8. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR8. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR8 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR8 expression and for prevention or treatment of diseases wherein modulation of TLR8 expression would be beneficial are provided.
摘要翻译： 提供反义寡核苷酸化合物，组合物和方法用于下调TLR8的表达。 组合物包含靶向编码TLR8的核酸的反义寡核苷酸。 组合物还可包含靶向编码TLR8的核酸与其它治疗和/或预防化合物和/或组合物组合的反义寡核苷酸。 提供这些化合物和组合物用于下调TLR8表达和预防或治疗其中调节TLR8表达将是有益的疾病的方法。
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22.发明申请MODULATION OF TOLL-LIKE RECEPTOR 7 EXPRESSION BY ANTISENSE OLIGONUCLEOTIDES 审中-公开抗体寡核苷酸表达类似受体受体7的表达调控公开(公告)号：US20100041734A1
公开(公告)日：2010-02-18
申请号：US12534462
申请日：2009-08-03
申请人： Ekambar Kandimalla , Mallikarjuna Putta , Lakshmi Bhagat , Daqing Wang , Dong Yu , FuGang Zhu , Sudhir Agrawal
发明人： Ekambar Kandimalla , Mallikarjuna Putta , Lakshmi Bhagat , Daqing Wang , Dong Yu , FuGang Zhu , Sudhir Agrawal
CPC分类号： A61K31/7105 , Y02A50/401 , Y02A50/411 , Y02A50/414
摘要： Antisense oligonucleotide compounds, compositions and methods are provided for down regulating the expression of TLR7. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding TLR7. The compositions may also comprise antisense oligonucleotides targeted to nucleic acids encoding TLR7 in combination with other therapeutic and/or prophylactic compounds and/or compositions. Methods of using these compounds and compositions for down-regulating TLR7 expression and for prevention or treatment of diseases wherein modulation of TLR7 expression would be beneficial are provided.
摘要翻译： 提供反义寡核苷酸化合物，组合物和方法用于下调TLR7的表达。 组合物包含靶向编码TLR7的核酸的反义寡核苷酸。 组合物还可以包含靶向编码TLR7的核酸与其它治疗和/或预防化合物和/或组合物组合的反义寡核苷酸。 提供了这些化合物和组合物用于下调TLR7表达和预防或治疗其中调节TLR7表达将是有益的疾病的方法。
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23.发明申请公开(公告)号：US20090087388A1
公开(公告)日：2009-04-02
申请号：US12140334
申请日：2008-06-17
申请人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
发明人： Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
IPC分类号： A61K9/12 , A61K31/7088 , A61K39/00 , A61K39/395 , A61K8/49 , A61K38/00 , A61K39/35
CPC分类号： A61K48/00 , A61K31/7088 , A61K39/0008 , A61K2039/55561 , Y02A50/401
摘要： The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
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公开(公告)号：US07498426B2
公开(公告)日：2009-03-03
申请号：US11234074
申请日：2005-09-22
申请人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu
发明人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu
CPC分类号： A61K39/39 , A61K2039/55561
摘要： The invention provides an immunostimulatory nucleic acid. In certain embodiments according to this aspect of the invention, the sequence of the immunostimulatory oligonucleotide and/or immunomer is at least partially self-complementary.
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公开(公告)号：US07427405B2
公开(公告)日：2008-09-23
申请号：US11174282
申请日：2005-07-01
申请人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu
发明人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu
CPC分类号： A61K39/39 , A61K2039/55561
摘要： The invention provides an immunostimulatory nucleic acid. In certain embodiments according to this aspect of the invention, the sequence of the immunostimulatory oligonucleotide and/or immunomer is at least partially self-complementary.
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26.发明申请Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends 有权通过最优化5'末端调节基于寡核苷酸的化合物的免疫刺激性质公开(公告)号：US20070173469A1
公开(公告)日：2007-07-26
申请号：US10925873
申请日：2004-08-25
申请人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu , Lakshmi Bhagat
发明人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu , Lakshmi Bhagat
CPC分类号： C07H21/04 , A61K39/39 , A61K2039/55561
摘要： The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers of the invention comprise at least two oligonucleotides linked at their 3′ ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5′ end.
摘要翻译： 本发明涉及在免疫治疗应用中寡核苷酸作为免疫刺激剂的治疗用途。 更具体地，本发明提供了用于产生免疫应答的方法或用于治疗需要免疫刺激的患者的免疫
性。 本发明的免疫体包含至少两个在其3'末端连接的寡核苷酸，核苷间键或官能化核碱基或糖与非核苷酸连接体，至少一个寡核苷酸是免疫刺激性寡核苷酸并具有可接近的5'端。-
27.发明申请Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides 失效包含修饰的免疫刺激二核苷酸的基于寡核苷酸的化合物的免疫刺激性质公开(公告)号：US20070105801A1
公开(公告)日：2007-05-10
申请号：US11268714
申请日：2005-11-07
申请人： Sudhir Agrawal , Dong Yu , Ekambar Kandimalla
发明人： Sudhir Agrawal , Dong Yu , Ekambar Kandimalla
CPC分类号： A61K31/70
摘要： The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides an immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunostimulatory oligonucleotides according to the invention further comprise at least two oligonucleotides linked at their 3′ ends, intemucleoside linkages or finctionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5′ end.
摘要翻译： 本发明涉及在免疫治疗应用中寡核苷酸作为免疫刺激剂的治疗用途。 更具体地，本发明提供了用于产生免疫应答的方法或用于治疗需要免疫刺激的患者的免疫刺激性寡核苷酸。 本发明的免疫刺激性寡核苷酸优选包含新的嘌呤。 根据本发明的免疫刺激性寡核苷酸进一步包含至少两个在其3'末端连接的寡核苷酸，核苷键或核苷酸碱基或糖与非核酸连接体，至少一个寡核苷酸是免疫刺激性寡核苷酸，具有可接近的5' 结束。
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公开(公告)号：US20070093439A1
公开(公告)日：2007-04-26
申请号：US11257769
申请日：2005-10-25
申请人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu , Lakshmi Bhagat
发明人： Sudhir Agrawal , Ekambar Kandimalla , Dong Yu , Lakshmi Bhagat
CPC分类号： A61K39/39 , A61K2039/55561
摘要： The invention relates to modulation of the immune system. More particularly, the invention relates to modulating the immune system through the use of oligonucleotide-derived compounds. The invention provides immunostimulatory agents that are less expensive to make than existing immunostimulatory oligonucleotides. The immunostimulatory agents according to the invention can, in preferred embodiments, cause immune stimulation across species lines.
摘要翻译： 本发明涉及免疫系统的调节。 更具体地，本发明涉及通过使用寡核苷酸衍生的化合物调节免疫系统。 本发明提供免疫刺激剂，其比现有免疫刺激性寡核苷酸便宜。 在优选实施方案中，根据本发明的免疫刺激剂可以跨物种系引起免疫刺激。
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公开(公告)号：US20060287261A1
公开(公告)日：2006-12-21
申请号：US11173794
申请日：2005-07-01
申请人： Sudhir Agrawal , Lakshmi Bhagat , Dong Yu , Ekambar Kandimalla
发明人： Sudhir Agrawal , Lakshmi Bhagat , Dong Yu , Ekambar Kandimalla
CPC分类号： C12N15/117 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/111 , C12N2310/17 , C12N2310/33 , C12N2310/3519 , C12N2310/51
摘要： The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides immunomers and an immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunomers and an immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunomers according to the invention further comprise at least two oligonucleotides linked at their 3′ ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunomodulatory oligonucleotide and having an accessible 5′ end.
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公开(公告)号：US20060135454A1
公开(公告)日：2006-06-22
申请号：US10694207
申请日：2003-10-27
申请人： Ekambar Kandimalla , Qiuyan Zhao , Dong Yu , Sudhir Agrawal
发明人： Ekambar Kandimalla , Qiuyan Zhao , Dong Yu , Sudhir Agrawal
IPC分类号： A61K48/00
CPC分类号： C12N15/117 , A61K31/7088 , A61K31/7115 , A61K2039/55561 , C07H21/00 , C12N2310/18 , C12N2310/3125 , C12N2310/317 , C12N2310/318 , C12N2310/32 , C12N2310/321 , C12N2310/33 , C12N2310/334 , C12N2310/336 , C12N2310/3521
摘要： The invention relates to the therapeutic use of oligonucleotides or oligonucleotide analogs as immunostimulatory agents in immunotherapy applications. The invention provides methods for enhancing the immune response caused by immunostimulatory oligonucleotide compounds.
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