公开(公告)号：US08846669B2

公开(公告)日：2014-09-30

申请号：US14008702

申请日：2012-03-29

Applicant: Young Lag Cho ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sun Young Kim ,  Hong Bum Lee ,  Hyang Sook Lee ,  Kyuman Oh ,  Hye Jin Heo ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

Inventor： Young Lag Cho ,  Sung Yoon Baek ,  Sang Eun Chae ,  Sun Young Kim ,  Hong Bum Lee ,  Hyang Sook Lee ,  Kyuman Oh ,  Hye Jin Heo ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC: C07D413/14 ,  A61K31/53 ,  A61K31/5355

CPC classification number: C07D413/14

Abstract: Disclosed is a novel oxazolidinone derivative represented by Formula 1 above, in particular, a novel oxazolidinone compound having a cyclic amidoxime or cyclic amidrazone group.In Formula 1, R and Q are the same as defined in the detailed description.In addition, disclosed is a pharmaceutical composition for an antibiotic which includes the novel oxazolidinone derivative of Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an active ingredient.The novel oxazolidinone derivative, the prodrug thereof, the hydrate thereof, the solvate thereof, the isomer thereof, and the pharmaceutically acceptable salt thereof have broad antibacterial spectrum against resistant bacteria, low toxicity and strong antibacterial effects against Gram-positive and Gram-negative bacteria and thus may be effectively used as antibiotics.

Abstract translation: 公开了上述通式1所示的新型恶唑烷酮衍生物，特别是具有环状偕胺肟或环状氨基腙基的新型恶唑烷酮化合物。 在式1中，R和Q与详细描述中定义相同。 此外，公开了一种抗生素的药物组合物，其包含式1的新型恶唑烷酮衍生物，其前药，其水合物，其溶剂合物，其异构体或其药学上可接受的盐作为活性成分。 新型恶唑烷酮衍生物，其前体药剂，其水合物，其溶剂合物，其异构体及其药学上可接受的盐具有抗抗性细菌的抗菌谱，对革兰氏阳性和革兰氏阴性菌具有低毒性和强抗菌作用 因此可以有效地用作抗生素。

公开(公告)号：US08329684B2

公开(公告)日：2012-12-11

申请号：US13467019

申请日：2012-05-08

Applicant: Young Lag Cho ,  Joung Yul Yun ,  Sang Eun Chae ,  Chul Soon Park ,  Hyang Sook Lee ,  Kyu Man Oh ,  Hye Jin Kang ,  Dae Hyuck Kang ,  Young Jae Yang ,  Hyun Jin Kwon ,  Tae Kyo Park ,  Sung Ho Woo ,  Young Zu Kim

Inventor： Young Lag Cho ,  Joung Yul Yun ,  Sang Eun Chae ,  Chul Soon Park ,  Hyang Sook Lee ,  Kyu Man Oh ,  Hye Jin Kang ,  Dae Hyuck Kang ,  Young Jae Yang ,  Hyun Jin Kwon ,  Tae Kyo Park ,  Sung Ho Woo ,  Young Zu Kim

IPC: A61K31/545 ,  C07D501/14

CPC classification number: C07D501/60 ,  C07D501/24 ,  C07D501/46

Abstract: The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. Compounds of the present invention are effective ingredients for the broad spectrum of antibiotic resistance, exhibit low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.

Abstract translation: 本发明涉及由化学式1表示的新型头孢菌素衍生物。其中，X，Y，L，R 1和R 2与本发明的描述中所定义相同。 本发明还涉及药物抗生素组合物，其包含由化学式1表示的新型胞孢素衍生物，其前药，其水合物，其溶剂合物，其异构体或其药学上可接受的盐作为有效成分。 本发明的化合物是广谱抗生素抗性的有效成分，表现出低毒性，特别是在革兰氏阴性细菌中，其可用于强抗微生物活性。

公开(公告)号：US08242113B2

公开(公告)日：2012-08-14

申请号：US13120568

申请日：2009-09-22

Applicant: Young Lag Cho ,  Sang Eun Chae ,  Sung Yoon Baek ,  Yeon Ok Kim ,  Seong Jin Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

Inventor： Young Lag Cho ,  Sang Eun Chae ,  Sung Yoon Baek ,  Yeon Ok Kim ,  Seong Jin Kim ,  Hyang Sook Lee ,  Ju Hyun Park ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC: C07D403/08 ,  A61K31/5377

CPC classification number: C07D403/08

Abstract: Disclosed is a novel oxazolidinone derivative, particularly a novel oxazolidinone compound with a cyclic amidoxime or cyclic amidrazone group. Also disclosed is a pharmaceutical antibiotic composition including a novel oxazolidinone derivative, in vivo hydrolysable ester thereof, in vivo hydrolysable phosphate ester thereof, an isomer thereof or a pharmaceutically acceptable salt thereof as an effective ingredient. Because the novel oxazolidinone derivative, in vivo hydrolysable ester thereof, in vivo hydrolysable phosphate ester thereof, an isomer thereof or a pharmaceutically acceptable salt thereof exhibits a wide antibacterial spectrum against resistant bacteria, a low toxicity, and a strong antibacterial activity against Gram-positive and Gram-negative bacteria, it can be usefully used as an antibiotic.

Abstract translation: 公开了一种新的恶唑烷酮衍生物，特别是具有环偕胺肟或环状氨基腙基团的新型恶唑烷酮化合物。 还公开了包含新的恶唑烷酮衍生物，其体内可水解的酯，其体内可水解的磷酸酯，其异构体或其药学上可接受的盐作为有效成分的药物抗生素组合物。 因为新的恶唑烷酮衍生物，其体内可水解的酯，其体内可水解的磷酸酯，其异构体或其药学上可接受的盐，表现出对抗细菌的抗菌谱广，毒性低，抗革兰氏阳性 和革兰阴性菌，可以有效地用作抗生素。

公开(公告)号：US20120136149A1

公开(公告)日：2012-05-31

申请号：US13382235

申请日：2010-07-07

Applicant: Young Lag Cho ,  Sang Eun Chae ,  Seong Jin Kim ,  Ho Young Song ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim ,  Jinhwa Lee ,  Suk Ho Lee

Inventor： Young Lag Cho ,  Sang Eun Chae ,  Seong Jin Kim ,  Ho Young Song ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim ,  Jinhwa Lee ,  Suk Ho Lee

IPC: C07D253/06

CPC classification number: C07D413/14 ,  C07D253/06 ,  C07D409/12

Abstract: Disclosed are: a method for preparing a 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}-methyl)thiophene-2-carboxamide derivative, which is a inhibitor of blood coagulation factor Xa, in a high purity and yield; and a novel intermedicate used therein.

Abstract translation: 公开的是：制备5-氯-N - （{（5S）-2-氧-3- [4-（5,6-二氢-4H- [1,2,4]三嗪-1-基 ）苯基] -1,3-恶唑烷-5-基} - 甲基）噻吩-2-甲酰胺衍生物，其是凝血因子Xa的抑制剂，其纯度高，产率高; 和其中使用的新颖的介入。

公开(公告)号：US20120108808A1

公开(公告)日：2012-05-03

申请号：US13382265

申请日：2010-07-07

Applicant: Young Lag Cho ,  Jong Un Cho ,  Sung Yoon Baek ,  Ho Young Song ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

Inventor： Young Lag Cho ,  Jong Un Cho ,  Sung Yoon Baek ,  Ho Young Song ,  Tae Kyo Park ,  Sung Ho Woo ,  Yong Zu Kim

IPC: C07D273/04

CPC classification number: C07D413/14 ,  C07D413/12

Abstract: Provided is a method for preparing (S)-5-chloro-N-((3-(4-(5,6-dihydro-4H-1,2,4-oxadiazin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide derivatives of Formula (I) which are useful as blood coagulation factor Xa inhibitors, and said method using 1-fluoro-4-nitrobenzen as a starting material. According to the method of the present invention, (S)-5-chloro-N-((3-(4-(5,6-dihydro-4H-1,2,4-oxadiazin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)thiophene-2-carboxamide derivatives of Formula (I) which are useful as blood coagulation factor Xa inhibitors can be prepared in a high purity and a high yield.

Abstract translation: 提供制备（S）-5-氯-N - （（3-（4-（5,6-二氢-4H-1,2,4-恶二嗪-3-基）苯基）-2-氧代恶唑烷 -5-基）甲基）噻吩-2-甲酰胺衍生物，所述方法使用1-氟-4-硝基苯作为原料，所述方法可用作凝血因子Xa抑制剂。 根据本发明的方法，（S）-5-氯-N - （（3-（4-（5,6-二氢-4H-1,2,4-恶二嗪-3-基）苯基） - 可用作凝血因子Xa抑制剂的式（I）的噻吩-2-甲酰胺衍生物可以以高纯度和高收率制备。

公开(公告)号：US20080074290A1

公开(公告)日：2008-03-27

申请号：US11782485

申请日：2007-07-24

Applicant: Sung Ho Woo ,  Jun Jeong Lee ,  Seon Hui Kim

Inventor： Sung Ho Woo ,  Jun Jeong Lee ,  Seon Hui Kim

IPC: G08G1/065

CPC classification number: G08G1/092 ,  G08G1/093

Abstract: A method and terminal for receiving and processing traffic information and a method and apparatus for providing the traffic information are disclosed. According to an embodiment, the method for receiving traffic information includes reading region information included in received traffic information, determining whether a first region indicated by the region information overlaps with a second region corresponding to location information on which traffic information is desired, and decoding the traffic information including the region information indicating the first region if the determination result indicates that the first and second regions overlap.

Abstract translation: 公开了一种用于接收和处理交通信息的方法和终端以及用于提供交通信息的方法和装置。 根据实施例，接收业务信息的方法包括：接收到的业务信息中包含的读取区域信息，确定由所述区域信息表示的第一区域是否与对应于期望交通信息的位置信息相对应的第二区域重叠， 如果确定结果指示第一和第二区域重叠，则包括指示第一区域的区域信息的交通信息。

公开(公告)号：US06344080B1

公开(公告)日：2002-02-05

申请号：US09570786

申请日：2000-05-15

Applicant: Jeong Jun Kim ,  Sung Ho Woo ,  Hee Kwon Chae ,  Chang Woo Park

Inventor： Jeong Jun Kim ,  Sung Ho Woo ,  Hee Kwon Chae ,  Chang Woo Park

IPC: C04B3504

CPC classification number: C03C17/25 ,  C03C2217/228 ,  C03C2217/23

Abstract: Protection film composition for a plasma display panel consisting of a metal oxide including 60 wt %˜90 wt % of magnesium 2-methoxyethoxide, and 10 wt %˜40 wt % of metal polyoxohydroxide, and an organic solvent, thereby enhancing a luminance, reducing a discharge current and discharge voltage required for providing the same luminance, and permitting to form an excellent magnesium oxide thin film having no pin hole, crack, and excellent electric characteristics.

Abstract translation: 由包含60重量％〜90重量％的2-甲氧基乙醇镁的金属氧化物和10重量％〜40重量％的金属多氧化氢和有机溶剂组成的等离子体显示面板的保护膜组合物，从而提高亮度，降低 提供相同亮度所需的放电电流和放电电压，并且可以形成没有针孔，裂纹和优异的电特性的优异的氧化镁薄膜。