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公开(公告)号：US07230017B2
公开(公告)日：2007-06-12
申请号：US10525608
申请日：2003-08-18
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/4412 , A61K31/444 , A61K31/5377 , A61K31/4439 , A61K31/4436 , A61K31/496 , A61K31/4545 , C07D401/02 , C07D413/02 , C07D211/86 , C07D213/22 , C07D417/02
CPC分类号： C07D401/04 , C07D211/90 , C07D405/04 , C07F7/1804
摘要： The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译： 本发明涉及新的二氢吡啶酮衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。
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22.发明授权Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes 有权嘧啶酮衍生物作为抗急性和慢性炎性，缺血和重塑过程的治疗剂公开(公告)号：US07687510B2
公开(公告)日：2010-03-30
申请号：US10527391
申请日：2003-08-28
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： C07D239/22 , C07D401/04 , A61K31/5377
CPC分类号： C07D239/22 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12
摘要： The invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases.
摘要翻译： 本发明涉及新型杂环衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病。
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23.发明申请I-PHENY 1-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVES AND THEIR USE 失效I-PHENY 1-3,4-二羟基嘧啶-2（1H） - 酮衍生物及其用途公开(公告)号：US20100022537A1
公开(公告)日：2010-01-28
申请号：US12509936
申请日：2009-07-27
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenieh , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenieh , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/5377 , C07D239/02 , A61K31/505 , C07D413/02 , A61P29/00 , A61P9/00
CPC分类号： C07D239/22 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： This invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译： 本发明涉及新型杂环衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。
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24.发明授权Dihydropyridine derivatives for use as human neutrophil elastase inhibitors 失效用作人嗜中性粒细胞弹性蛋白酶抑制剂的二氢吡啶衍生物公开(公告)号：US07691854B2
公开(公告)日：2010-04-06
申请号：US10525867
申请日：2003-08-18
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/44 , C07D213/72 , C07D401/02
CPC分类号： C07D401/04 , C07D211/90 , C07D405/04 , C07D413/04 , C07D417/04
摘要： The invention relates to novel dihydropyridine derivatives, of Formula (I) processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译： 本发明涉及式（I）的新型二氢吡啶衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。
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25.发明授权I-pheny 1-3,4-dihydropyrimidin-2(1H)-one derivatives and their use 失效1-苯基-1,3,4-二氢嘧啶-2（1H） - 酮衍生物及其用途公开(公告)号：US08173665B2
公开(公告)日：2012-05-08
申请号：US12509936
申请日：2009-07-27
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenieh , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenieh , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D239/22 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The invention relates to 4-cyanophenyl, 2-sulfanyl, 1-phenyl pyrimidine derivatives, processes for their preparation, and pharmaceutical compositions of the same. Compounds and compositions of the invention are useful in the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction, and heart failure development.
摘要翻译： 本发明涉及4-氰基苯基，2-硫烷基，1-苯基嘧啶衍生物，其制备方法及其药物组合物。 本发明的化合物和组合物可用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗死和心力衰竭发展。
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公开(公告)号：US20110183928A1
公开(公告)日：2011-07-28
申请号：US13001095
申请日：2009-06-18
申请人： Kai Thede , Elisabeth Woltering , Peter Kolkhof , Carsten Schmeck , Elisabeth Pook , Alexander Hillisch , Lars Bärfacker , Klemens Lustig , Dieter Lang , Martin Radtke , Rolf Grosser , Astrid Brüns , Michael Gerisch
发明人： Kai Thede , Elisabeth Woltering , Peter Kolkhof , Carsten Schmeck , Elisabeth Pook , Alexander Hillisch , Lars Bärfacker , Klemens Lustig , Dieter Lang , Martin Radtke , Rolf Grosser , Astrid Brüns , Michael Gerisch
IPC分类号： A61K31/404 , C07D209/12 , C07D209/18 , C07D471/04 , C07D409/06 , A61K31/437 , A61K31/616 , A61K31/7048 , A61P9/12 , A61P9/00 , A61P13/12 , A61P1/16 , A61P5/40 , A61P9/04
CPC分类号： C07D209/10 , C07D487/04
摘要： The present application relates to novel 3-cyanoalkyl- and 3-hydroxyalkyl-substituted indole derivatives, to processes for preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular diseases.
摘要翻译： 本申请涉及新的3-氰基烷基 - 和3-羟基烷基取代的吲哚衍生物，其制备方法，单独使用或组合用于治疗和/或预防疾病，以及其用于生产 用于治疗和/或预防疾病的药物，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US09206185B2
公开(公告)日：2015-12-08
申请号：US14007427
申请日：2012-04-05
申请人： Lars Bärfacker , William Scott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Hans Briem , Ulf Bömer
发明人： Lars Bärfacker , William Scott , Andrea Hägebarth , Stuart Ince , Hartmut Rehwinkel , Oliver Politz , Roland Neuhaus , Hans Briem , Ulf Bömer
IPC分类号： C07D487/04 , A61K31/5025 , A61K45/06
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06
摘要： The application relates to imidazopyridazines of formula (I) which are useful as Akt inhibitors suitable for the treatment of cancer, and processes for their production and the use thereof.
摘要翻译： 本申请涉及可用作适于治疗癌症的Akt抑制剂及其制备方法及其用途的式（I）咪唑并哒嗪。
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公开(公告)号：US20120010224A1
公开(公告)日：2012-01-12
申请号：US13233833
申请日：2011-09-15
申请人： Martin HENDRIX , Lars Bärfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
发明人： Martin HENDRIX , Lars Bärfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC分类号： A61K31/519 , A61P25/28 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to novel 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.
摘要翻译： 本发明涉及新的6-环甲基 - 和6-烷基甲基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。
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公开(公告)号：US08822479B2
公开(公告)日：2014-09-02
申请号：US12950386
申请日：2010-11-19
申请人： Martin Hendrix , Lars Bärfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
发明人： Martin Hendrix , Lars Bärfacker , Christina Erb , Frank-Thorsten Hafner , Heike Heckroth , Dagmar Karthaus , Adrian Tersteegen , Franz-Josef van der Staay , Marja van Kampen
IPC分类号： A61K31/519 , A61P25/28 , A61P25/18 , C07D487/04
CPC分类号： C07D487/04 , A61K31/519
摘要： The invention relates to 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines, process for their preparation, and their use for producing medicaments for improving learning and/or memory. The 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines are of the formula (I): with the variables as defined in the claims.
摘要翻译： 本发明涉及6-环甲基 - 和6-烷基甲基取代的吡唑并嘧啶，其制备方法及其用于生产改善学习和/或记忆的药物的用途。 6-环甲基 - 和6-烷基甲基取代的吡唑并嘧啶具有式（I）：与权利要求中所定义的变量。
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公开(公告)号：US08143411B2
公开(公告)日：2012-03-27
申请号：US12676568
申请日：2008-08-26
申请人： Lars Bärfacker , Barbara Albrecht-Küpper , Peter Kolkhof , Yolanda Cancho Grande , Adam Nitsche , Heinrich Meier , Carsten Schmeck , Jens Schamberger , Klemens Lustig
发明人： Lars Bärfacker , Barbara Albrecht-Küpper , Peter Kolkhof , Yolanda Cancho Grande , Adam Nitsche , Heinrich Meier , Carsten Schmeck , Jens Schamberger , Klemens Lustig
IPC分类号： C07D211/78 , A61K31/44
CPC分类号： C07D213/80
摘要： The present application relates to novel substituted 6-phenylnicotinic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders, in particular dyslipidaemias, arteriosclerosis and heart failure.
摘要翻译： 本申请涉及新的取代的6-苯基烟酸衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于 治疗和/或预防心血管疾病，特别是血脂异常，动脉硬化和心力衰竭。
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