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公开(公告)号：US08143411B2
公开(公告)日：2012-03-27
申请号：US12676568
申请日：2008-08-26
申请人： Lars Bärfacker , Barbara Albrecht-Küpper , Peter Kolkhof , Yolanda Cancho Grande , Adam Nitsche , Heinrich Meier , Carsten Schmeck , Jens Schamberger , Klemens Lustig
发明人： Lars Bärfacker , Barbara Albrecht-Küpper , Peter Kolkhof , Yolanda Cancho Grande , Adam Nitsche , Heinrich Meier , Carsten Schmeck , Jens Schamberger , Klemens Lustig
IPC分类号： C07D211/78 , A61K31/44
CPC分类号： C07D213/80
摘要： The present application relates to novel substituted 6-phenylnicotinic acid derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders, in particular dyslipidaemias, arteriosclerosis and heart failure.
摘要翻译： 本申请涉及新的取代的6-苯基烟酸衍生物，其制备方法，其用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于 治疗和/或预防心血管疾病，特别是血脂异常，动脉硬化和心力衰竭。
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公开(公告)号：US20100099681A1
公开(公告)日：2010-04-22
申请号：US12540657
申请日：2009-08-13
申请人： Lars Bärfacker , Raimund Kast , Nils Griebenow , Heinrich Meier , Peter Kolkhof , Barbara Albrecht-Küpper , Adam Nitsche , Nicole Teusch , Johannes-Peter Stasch , Dirk Schneider
发明人： Lars Bärfacker , Raimund Kast , Nils Griebenow , Heinrich Meier , Peter Kolkhof , Barbara Albrecht-Küpper , Adam Nitsche , Nicole Teusch , Johannes-Peter Stasch , Dirk Schneider
IPC分类号： A61K31/498 , A61K31/517 , A61K31/437 , A61K31/4709 , A61K31/415 , C07D403/10 , C07D231/38 , A61P9/00
CPC分类号： C07D403/04 , C07D401/04 , C07D417/04 , C07D471/04
摘要： The present application relates to novel substituted 5-aminopyrazoles, methods of production thereof, use thereof alone or in combinations for the treatment and/or prophylaxis of diseases and use thereof for the production of medicinal products for the treatment and/or prophylaxis of diseases.
摘要翻译： 本申请涉及新型取代的5-氨基吡唑，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途。
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3.发明授权Substituted-4-aryl-1,4-dihydro-1,6-naphthyridinamides and use thereof 有权取代的4-芳基-1,4-二氢-1,6-萘啶酰胺及其用途公开(公告)号：US08436180B2
公开(公告)日：2013-05-07
申请号：US12526951
申请日：2008-02-19
申请人： Lars Bärfacker , Peter Kolkhof , Karl-Heinz Schlemmer , Rolf Grosser , Adam Nitsche , Martina Klein , Klaus Münter , Barbara Albrecht-Küpper , Elke Hartmann
发明人： Lars Bärfacker , Peter Kolkhof , Karl-Heinz Schlemmer , Rolf Grosser , Adam Nitsche , Martina Klein , Klaus Münter , Barbara Albrecht-Küpper , Elke Hartmann
IPC分类号： C07D471/02 , A61K31/44
CPC分类号： C07D471/04
摘要： The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridine-3-carboxamides, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的4-芳基-1,4-二氢-1,6-二氮杂萘-3-甲酰胺，其制备方法，其用于治疗和/或预防疾病的用途及其用于 制造用于治疗和/或预防疾病，特别是心血管疾病的药物。
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4.发明申请SUBSTITUTED-4-ARYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINAMIDES AND USE THEREOF 有权取代的4-亚芳基-1,4-二氢-1,6-萘啶酰胺及其用途公开(公告)号：US20100136142A1
公开(公告)日：2010-06-03
申请号：US12526951
申请日：2008-02-19
申请人： Lars Bärfacker , Peter Kolkhof , Karl-Heinz Schlemmer , Rolf Grosser , Adam Nitsche , Martina Klein , Klaus Münter , Barbara Albrecht-Küpper , Elke Hartmann
发明人： Lars Bärfacker , Peter Kolkhof , Karl-Heinz Schlemmer , Rolf Grosser , Adam Nitsche , Martina Klein , Klaus Münter , Barbara Albrecht-Küpper , Elke Hartmann
IPC分类号： A61K33/00 , C07D471/04 , A61K31/4375 , A61P7/12 , A61P1/16 , A61P9/10 , A61P9/12 , A61P13/12 , A61K31/60 , A61K31/704
CPC分类号： C07D471/04
摘要： The present application relates to novel substituted 4-aryl-1,4-dihydro-1,6-naphthyridine-3-carboxamides, a process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的4-芳基-1,4-二氢-1,6-二氮杂萘-3-甲酰胺，其制备方法，其用于治疗和/或预防疾病的用途及其用于 制造用于治疗和/或预防疾病，特别是心血管疾病的药物。
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5.发明授权公开(公告)号：US09040566B2
公开(公告)日：2015-05-26
申请号：US13819790
申请日：2011-08-29
申请人： Jürgen Klar , Georges Von Degenfeld , Hans-Georg Lerchen , Barbara Albrecht-Küpper , Andreas Knorr , Peter Sandner , Daniel Meibom
发明人： Jürgen Klar , Georges Von Degenfeld , Hans-Georg Lerchen , Barbara Albrecht-Küpper , Andreas Knorr , Peter Sandner , Daniel Meibom
IPC分类号： A01N43/40 , A61K31/44 , C07D409/00 , C07D411/00 , C07D405/00 , C07D417/12 , A61K9/00 , A61K9/08 , A61K31/4439 , A61K45/06 , C07D413/12 , C07D417/14
CPC分类号： A61K31/4439 , A61K9/0048 , A61K9/08 , A61K38/05 , A61K45/06 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention relates to the use of selective adenosine A1 agonists, in particular the dicyanopyridines of formula (I), for the treatment and/or prophylaxis of glaucoma and ocular hypertension as well as the their use for the production of a medicament for the treatment and/or prophylaxis of glaucoma and ocular hypertension.
摘要翻译： 本发明涉及选择性腺苷A1激动剂，特别是式（I）的二氰基吡啶用于治疗和/或预防青光眼和高眼压症及其用于生产治疗药物的用途的用途 和/或预防青光眼和高眼压症。
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公开(公告)号：US20110294719A1
公开(公告)日：2011-12-01
申请号：US13132991
申请日：2009-12-03
申请人： Hans-Georg Lerchen , Daniel Meibom , Alexandros Vakalopoulos , Barbara Albrecht-Küpper , Joerg Keldenich , Katja Zimmermann , Peter Nell , Ursula Krenz
发明人： Hans-Georg Lerchen , Daniel Meibom , Alexandros Vakalopoulos , Barbara Albrecht-Küpper , Joerg Keldenich , Katja Zimmermann , Peter Nell , Ursula Krenz
CPC分类号： C07D413/12 , A61K31/4439 , C07K5/0202 , C07K5/0205 , C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06078 , C07K5/06086 , C07K5/06104 , C07K5/06113 , C07K5/06147 , C07K5/06165
摘要： The present application relates to dipeptide-like prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-oxazol-4-yl]methyl}sulfanyl)-4-(4-{[2,3-dihydroxypropyl]oxy}phenyl)pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.
摘要翻译： 本申请涉及2-氨基-6 - （{[2-（4-氯苯基）-1,3-恶唑-4-基]甲基}硫烷基）-4-（4 - {[ 2,3-二羟基丙基]氧基}苯基）吡啶-3,5-二腈，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防的药物的用途 的疾病，特别是心血管疾病。
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公开(公告)号：US20110178137A1
公开(公告)日：2011-07-21
申请号：US13001193
申请日：2009-06-16
IPC分类号： A61K31/44 , C07D213/78 , A61P9/00
CPC分类号： A61K31/44
摘要： The present invention relates to pharmaceutical compositions and combinations for treating, preventing or managing heart failure and/or connected diseases therewith comprising 4{4-[3-(4-chloro-3-trifluoromethylphenyl)-ureido]-3-fluorophenoxy}-pyridine-2-carboxylic acid methylamide optionally combined with at least one additional therapeutic agent.
摘要翻译： 本发明涉及用于治疗，预防或控制心力衰竭和/或相关疾病的药物组合物和组合，其包含4 {4- [3-（4-氯-3-三氟甲基苯基） - 脲基] -3-氟苯氧基} - 吡啶 -2-羧酸甲基酰胺任选地与至少一种另外的治疗剂组合。
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公开(公告)号：US08618119B2
公开(公告)日：2013-12-31
申请号：US12809688
申请日：2008-12-09
申请人： Peter Nell , Alexandros Vakalopoulos , Frank Süβmeier , Barbara Albrecht-Küpper , Katja Zimmermann , Joerg Keldenich , Daniel Meibom
发明人： Peter Nell , Alexandros Vakalopoulos , Frank Süβmeier , Barbara Albrecht-Küpper , Katja Zimmermann , Joerg Keldenich , Daniel Meibom
IPC分类号： A01N43/90 , A61K31/519 , C07D491/00
CPC分类号： C07D471/04 , C07D215/54 , C07D221/04
摘要： The present application relates to novel substituted fused cyanopyridine derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新的取代的稠合氰基吡啶衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防疾病的药物的用途，优选用于治疗 和/或预防心血管疾病。
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9.发明授权公开(公告)号：US08304412B2
公开(公告)日：2012-11-06
申请号：US12516917
申请日：2007-11-17
申请人： Peter Nell , Walter Hübsch , Barbara Albrecht-Küpper , Alexandros Vakalopoulos , Frank Süssmeier , Jörg Keldenich , Joachim Telser
发明人： Peter Nell , Walter Hübsch , Barbara Albrecht-Küpper , Alexandros Vakalopoulos , Frank Süssmeier , Jörg Keldenich , Joachim Telser
IPC分类号： A61K31/5377 , A61K31/44 , A61K31/497 , A61P3/10 , C07D417/12 , C07D409/14 , C07D413/14
CPC分类号： C07D417/14 , C07D405/04 , C07D413/14 , C07D417/12
摘要： The present application relates to novel 4-cycloalkyl- and 4-heterocycloalkyl-3,5-dicyano-2-thio-pyridine derivatives, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of hypertension and other cardiovascular disorders.
摘要翻译： 本申请涉及新的4-环烷基 - 和4-杂环烷基-3,5-二氰基-2-硫代吡啶衍生物，其制备方法，其用于治疗和/或预防疾病及其用途 用于制备用于治疗和/或预防疾病的药物，优选用于治疗和/或预防高血压和其它心血管疾病。
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公开(公告)号：US20110263657A1
公开(公告)日：2011-10-27
申请号：US13001145
申请日：2009-06-18
CPC分类号： A61K31/44
摘要： The present invention relates to pharmaceutical compositions for treating, preventing or managing heart failure and/or connected diseases therewith comprising at least a diaryl urea compound optionally combined with at least one additional therapeutic agent. Useful combinations include e.g. BAY 43-9006 as a diaryl urea compound.
摘要翻译： 本发明涉及用于治疗，预防或控制心力衰竭和/或与之相关的疾病的药物组合物，其包含任选与至少一种另外的治疗剂组合的至少二芳基脲化合物。 有用的组合包括例如 BAY 43-9006作为二芳基脲化合物。
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