公开(公告)号：USPP13433P2

公开(公告)日：2002-12-31

申请号：US09940162

申请日：2001-08-24

申请人： Simon Smith

发明人： Simon Smith

IPC分类号： A01H500

CPC分类号： A01H5/02

摘要： A new cultivar of Ceanothus named ‘Perado’ that is characterized by an upright habit, small rounded pale blue flowers, variegated foliage with large dark green centers, and increased vigor over other variegated varieties, setting it apart from all other existing varieties of Ceanothus.

摘要翻译： 一个新的品种“豌豆”，其特征是直立的习惯，小圆形淡蓝色的花朵，杂色的树叶与大的深绿色中心，并增加了活力与其他杂色品种，使其脱离所有其他现有品种的Ceanothus。

公开(公告)号：US20080167326A1

公开(公告)日：2008-07-10

申请号：US11910092

申请日：2006-04-03

申请人： Witte Koopmann ,  Simon Smith

发明人： Witte Koopmann ,  Simon Smith

IPC分类号： A61K31/522 ,  C12Q1/68 ,  G01N33/53

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： The present invention relates to the discovery of an association between the gene encoding FGF-BP1 (fibroblast growth factor-binding protein) and chronic obstructive pulmonary disease (COPD). The invention identifies a role for FGF-BP1 in COPD. The present invention therefore relates to diagnostic techniques for the detection of COPD by detecting all or part of this gene, its precursors or products (mRNA, cDNA, genomic DNA, or protein). The present invention also provides methods and as-says for identifying compounds which modulate FGF-BP1 and which may be used for treating respiratory diseases such as COPD. Furthermore, the invention relates to polymorphisms in the genes encoding FGF-BP1. The invention also relates to the use of polymorphisms in the FGF-BP1-encoding genes in assessing predisposition and/or susceptibility of an individual to chronic obstructive pulmonary disease (COPD).

摘要翻译： 本发明涉及发现编码FGF-BP1（成纤维细胞生长因子结合蛋白）和慢性阻塞性肺病（COPD）的基因之间的联系。 本发明鉴定了FGF-BP1在COPD中的作用。 因此，本发明涉及通过检测该基因，其前体或产物（mRNA，cDNA，基因组DNA或蛋白质）的全部或部分来检测COPD的诊断技术。 本发明还提供了用于鉴定调节FGF-BP1并可用于治疗呼吸系统疾病如COPD的化合物的方法和说明。 此外，本发明涉及编码FGF-BP1的基因的多态性。 本发明还涉及FGF-BP1编码基因中多态性在评估个体对慢性阻塞性肺疾病（COPD）的倾向和/或易感性方面的用途。

公开(公告)号：US20060231093A1

公开(公告)日：2006-10-19

申请号：US10533707

申请日：2003-11-04

申请人： Simon Burge ,  Warren Isaacs ,  Simon Smith ,  Jonathan Tuckwell

发明人： Simon Burge ,  Warren Isaacs ,  Simon Smith ,  Jonathan Tuckwell

IPC分类号： A61M11/00 ,  A61M16/00

CPC分类号： A61M15/0091 ,  A61M15/0068 ,  A61M15/0073 ,  A61M15/009 ,  A61M15/0096

摘要： A pressurised medicament canister has a valve which dispenses a metered dose upon being released from a depressed condition. An inhaler device adapted for use with the canister has a breath-actuated latch mechanism arranged in use to latch the canister in a depressed condition and further to release the latch in response to inhalation through the inhaler by a user. Additionally, a dose counter for counting the number of doses dispensed from the canister comprising a counter member having a helical toothed track which is incrementally advanced each time a dose is dispensed from the canister. Also a valve for the canister comprising a sliding seal delimiting the metering chamber and slidable relative to a nozzle member, said sliding seal being biased in use to reduce the volume of the metering chamber substantially to zero once the metering chamber has been vented to the atmosphere.

摘要翻译： 加压药剂罐具有阀，其在从沮丧状态释放时分配计量剂量。 适于与罐一起使用的吸入器装置具有呼吸致动的闩锁机构，该呼吸致动的闩锁机构被布置成在使用中锁定罐处于沮丧状态，并且还响应于使用者通过吸入器的吸入而释放闩锁。 另外，用于对从罐分配的剂量数量进行计数的剂量计数器包括具有螺旋状齿轨道的计数器构件，每当从所述罐中分配剂量时，所述螺旋齿轨道逐渐地前进。 另外，用于罐的阀包括限定计量室并且可相对于喷嘴构件滑动的滑动密封件，所述滑动密封件在使用中被偏压，一旦计量室已经排放到大气中，计量室的体积基本上将其减小到零 。

公开(公告)号：US07107988B2

公开(公告)日：2006-09-19

申请号：US11045631

申请日：2005-01-28

申请人： John Pinon ,  Sameer Shirgaonkar ,  Christopher James Smith ,  Simon Burge ,  Max William Middleton ,  David Ahern ,  Matthew Neil Sarkar ,  Ben Arlett ,  Emma Lesley Lye ,  Simon Smith

发明人： John Pinon ,  Sameer Shirgaonkar ,  Christopher James Smith ,  Simon Burge ,  Max William Middleton ,  David Ahern ,  Matthew Neil Sarkar ,  Ben Arlett ,  Emma Lesley Lye ,  Simon Smith

IPC分类号： A61M15/00

CPC分类号： A61M15/0065 ,  A61M15/0026 ,  A61M15/0075 ,  A61M2202/062 ,  A61M2202/064 ,  A61M2206/16 ,  G06M1/04 ,  G06M1/045 ,  G06M1/248

摘要： A powder inhaler includes a container for storing powdered medicament. A metering member has a dosing recess and is moveable between a filling position in which the dosing recess is in alignment with an opening of the container, and an inhalation position in which it is in alignment with an inhalation channel. A mouthpiece is in communication with the inhalation channel for enabling inhalation of the dose of powdered medicament when in the inhalation position. A protective member provided between the metering member and the inhalation channel is moveable between a closed position in which the protective member covers the dosing recess, thereby preventing powdered medicament contained in the dosing recess from entering the inhalation channel, and an open position in which the protective member does not cover the dosing recess, thereby exposing the dosing recess to the inhalation channel for enabling inhalation of the dose of the powdered medicament.

摘要翻译： 粉末吸入器包括用于储存粉末状药物的容器。 计量构件具有计量凹槽，并且可以在填充位置之间移动，其中计量凹槽与容器的开口对准，以及吸入位置，其中吸入位置与吸入通道对齐。 吸嘴与吸入通道连通，用于在吸入位置时能够吸入剂量的粉末状药物。 设置在计量构件和吸入通道之间的保护构件可在闭合位置之间移动，在关闭位置中保护构件覆盖定量凹槽，从而防止包含在计量凹槽中的粉末药物进入吸入通道，并且打开位置 保护构件不覆盖定量凹槽，从而将计量凹槽暴露于吸入通道，以便吸入剂量的粉末状药物。

公开(公告)号：US20050222832A1

公开(公告)日：2005-10-06

申请号：US10812103

申请日：2004-03-30

申请人： Simon Smith ,  Geoff Barrett ,  Martin Vickers

发明人： Simon Smith ,  Geoff Barrett ,  Martin Vickers

IPC分类号： G06F17/50

CPC分类号： G06F17/5022

摘要： A method and system for simulation of an electronic circuit is provided, the circuit being represented by a network of a plurality of logic elements, the circuit comprising first and second asynchronous clock domains, whereby jitter elements are additionally inserted at predetermined portions of circuit boundaries between the first and second clock domains, the jitter elements being represented as logic elements, the values of which are randomly set.

摘要翻译： 提供了一种用于模拟电子电路的方法和系统，该电路由多个逻辑元件的网络表示，该电路包括第一和第二异步时钟域，由此将抖动元件另外插入在电路边界的预定部分 第一和第二时钟域，抖动元件被表示为逻辑元件，其值是随机设置的。

公开(公告)号：US20050004834A1

公开(公告)日：2005-01-06

申请号：US10841844

申请日：2004-05-07

申请人： Simon Smith

发明人： Simon Smith

IPC分类号： G06Q10/00 ,  G06F17/60

CPC分类号： G06Q10/10 ,  G06Q10/0639 ,  G06Q10/06398

摘要： The invention relates to a method and system for the analysis and development of an organisation and the use of elements and sub-elements identified within the organisation in an efficient manner in order to allow predetermined targets to be accomplished. This is achieved by allowing the performance of any said element and associated sub elements to be analysed effectively with respect to and with reference to an organisation representation in which the elements and sub-elements are located.

摘要翻译： 本发明涉及一种用于分析和开发组织的方法和系统，以及以有效的方式在组织内识别的元素和子元素的使用，以便实现预定目标。 这是通过允许相对于参考元件和子元件所在的组织表示而有效地分析任何所述元素和相关联子元素的性能来实现的。

公开(公告)号：USD472550S1

公开(公告)日：2003-04-01

申请号：US29123844

申请日：2000-05-24

申请人： Andreas Mehne ,  Margaret Crosthwaite ,  Simon Smith ,  David Ahern

设计人： Andreas Mehne ,  Margaret Crosthwaite ,  Simon Smith ,  David Ahern