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36 条记录 (耗时 0.025 秒)

    Process for protection of brain cells
    21.
    发明授权
    Process for protection of brain cells 失效
    保护脑细胞的过程

    公开(公告)号：US4835155A

    公开(公告)日：1989-05-30

    申请号：US87408

    申请日：1987-08-20

    申请人： Kyuya Kogure ,  Mitsuo Masaki

    发明人： Kyuya Kogure ,  Mitsuo Masaki

    IPC分类号： C07D295/08 ,  A61K31/495 ,  A61P25/28

    CPC分类号： A61K31/495

    摘要： A process for protection of brain cells comprises orally or parenterally administering into a man suffering from ischemia or being susceptable to ischemia a piperazine derivative having the formula: ##STR1## wherein R.sup.1 is hydrogen or a lower alkyl group, R.sup.2 is hydroxyl, an aralkyloxy group, a lower alkoxy group having 1-5 carbon atoms or a lower alkenyloxy group having 3-5 carbon atoms, R.sup.3 is hydrogen, an aralkyloxy group, a lower alkoxy group having 1-5 carbon atoms or a lower alkenyloxy group having 3-5 carbon atoms and R.sup.4 is hydrogen or a lower alkoxy group having 1-5 carbon atoms.

    摘要翻译： 保护脑细胞的方法包括口服或肠胃外给予患有缺血或易于缺血的人具有下式的哌嗪衍生物：其中R 1是氢或低级烷基，R 2是羟基，芳烷氧基 ，具有1-5个碳原子的低级烷氧基或具有3-5个碳原子的低级烯氧基，R3是氢，芳烷氧基，具有1-5个碳原子的低级烷氧基或具有3-5个碳原子的低级烯氧基 碳原子，R 4是氢或具有1-5个碳原子的低级烷氧基。

    Piperazine derivative having substituted phenyl groups
    26.
    发明授权
    Piperazine derivative having substituted phenyl groups 失效
    具有取代苯基的哌嗪衍生物

    公开(公告)号：US5446146A

    公开(公告)日：1995-08-29

    申请号：US255120

    申请日：1994-06-07

    申请人： Mitsuo Masaki ,  Tomio Yamakawa ,  Masaru Satoh ,  Hiromitsu Takeda ,  Yasushi Yoshino ,  Hitoshi Matsukura

    发明人： Mitsuo Masaki ,  Tomio Yamakawa ,  Masaru Satoh ,  Hiromitsu Takeda ,  Yasushi Yoshino ,  Hitoshi Matsukura

    IPC分类号： C07D295/21 ,  C07D317/60 ,  C07H15/26 ,  C07D243/08 ,  C07D295/194

    CPC分类号： C07D295/21 ,  C07D317/60 ,  C07H15/26

    摘要： A therapeutic agent for liver disease containing as an active ingredient a piperazine derivative having the formula: ##STR1## wherein, A represents a phenyl, p-benzoquinonyl or cumarinyl group which may have at least one substituent selected from the group consisting of halogen, alkyl, fluoroalkyl, formyl, alkoxycarbonyl, acyl, hydroxy, alkoxy, acyloxy, glycosyloxy, amino, alkylamino, mercapto, alkylthio and nitro; B represents a single bond or a straight chain alkylene group containing 1-4 carbon atoms which may have at least one substituent selected from the group consisting of alkyl, aryl, aralkyl, hydroxy and oxo; R represents an atom or a group selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, alkyl, cycloalkyl, aralkyl and aryl; and n is 2 or 8, or its pharmaceutically acceptable salt is diclosed.

    摘要翻译： 含有下列通式的哌嗪衍生物作为活性成分的肝病治疗剂：其中，A表示可具有至少一个取代基的苯基，对苯醌或类似的基团，所述取代基选自卤素，烷基 氟烷基，甲酰基，烷氧基羰基，酰基，羟基，烷氧基，酰氧基，糖氧基，氨基，烷基氨基，巯基，烷硫基和硝基; B表示单键或含有1-4个碳原子的直链亚烷基，其可以具有至少一个选自烷基，芳基，芳烷基，羟基和氧代的取代基; R表示选自氢，碱金属，碱土金属，烷基，环烷基，芳烷基和芳基的原子或基团。 并且n为2或8，或其药学上可接受的盐被包围。

    2-(4-Diphenylmethylpiperazinyl)-1-phenyl alkanol or their salts, a process for their production and a cerebral circulation-improving drug
    29.
    发明授权
    2-(4-Diphenylmethylpiperazinyl)-1-phenyl alkanol or their salts, a process for their production and a cerebral circulation-improving drug 失效
    2-（4-二苯基甲基哌嗪基）-1-苯基链烷醇或其盐，其制备方法和大脑循环改善药物

    公开(公告)号：US4528194A

    公开(公告)日：1985-07-09

    申请号：US513093

    申请日：1983-07-12

    申请人： Mitsuo Masaki

    发明人： Mitsuo Masaki

    IPC分类号： C07D295/08 ,  A61K31/495 ,  A61P7/02 ,  A61P9/08 ,  C07D295/084 ,  C07D295/108 ,  C07D241/04

    CPC分类号： C07D295/108 ,  C07D295/092

    摘要： A piperazine derivative of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a lower alkyl group; R.sup.2 is a hydroxyl group, an aralkyloxy group, a lower alkoxy group containing 1-5 carbon atoms or a lower alkenyloxy group containing 3-5 carbon atoms; R.sup.3 is a hydrogen atom, or an aralkyloxy group, a lower alkoxy group containing 1-5 carbon atoms or a lower alkenyloxy group containing 3-5 carbon atoms; and R.sup.4 is a hydrogen atom or a lower alkoxy group containing 1-5 carbon atoms, provided that R.sup.2 is a group other than the lower alkoxy group containing 1-5 carbon atoms when both R.sup.3 and R.sup.4 are hydrogen atoms; or a pharmaceutically acceptable salt is effectively useful as a cerebral circulation-improving agent.

    摘要翻译： 下式的哌嗪衍生物：其中R 1是氢原子或低级烷基; R2是羟基，芳烷氧基，含有1-5个碳原子的低级烷氧基或含有3-5个碳原子的低级烯氧基; R3是氢原子或芳烷氧基，含有1-5个碳原子的低级烷氧基或含有3-5个碳原子的低级烯氧基; 并且R 4为氢原子或含有1-5个碳原子的低级烷氧基，条件是当R 3和R 4均为氢原子时，R 2为除1-5个碳原子的低级烷氧基之外的基团; 或药学上可接受的盐作为脑循环改善剂有效地使用。