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102 条记录 (耗时 0.028 秒)

    Piperazine derivative having substituted phenyl groups
    2.
    发明授权
    Piperazine derivative having substituted phenyl groups 失效
    具有取代苯基的哌嗪衍生物

    公开(公告)号：US5446146A

    公开(公告)日：1995-08-29

    申请号：US255120

    申请日：1994-06-07

    申请人： Mitsuo Masaki ,  Tomio Yamakawa ,  Masaru Satoh ,  Hiromitsu Takeda ,  Yasushi Yoshino ,  Hitoshi Matsukura

    发明人： Mitsuo Masaki ,  Tomio Yamakawa ,  Masaru Satoh ,  Hiromitsu Takeda ,  Yasushi Yoshino ,  Hitoshi Matsukura

    IPC分类号： C07D295/21 ,  C07D317/60 ,  C07H15/26 ,  C07D243/08 ,  C07D295/194

    CPC分类号： C07D295/21 ,  C07D317/60 ,  C07H15/26

    摘要： A therapeutic agent for liver disease containing as an active ingredient a piperazine derivative having the formula: ##STR1## wherein, A represents a phenyl, p-benzoquinonyl or cumarinyl group which may have at least one substituent selected from the group consisting of halogen, alkyl, fluoroalkyl, formyl, alkoxycarbonyl, acyl, hydroxy, alkoxy, acyloxy, glycosyloxy, amino, alkylamino, mercapto, alkylthio and nitro; B represents a single bond or a straight chain alkylene group containing 1-4 carbon atoms which may have at least one substituent selected from the group consisting of alkyl, aryl, aralkyl, hydroxy and oxo; R represents an atom or a group selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, alkyl, cycloalkyl, aralkyl and aryl; and n is 2 or 8, or its pharmaceutically acceptable salt is diclosed.

    摘要翻译： 含有下列通式的哌嗪衍生物作为活性成分的肝病治疗剂：其中，A表示可具有至少一个取代基的苯基，对苯醌或类似的基团，所述取代基选自卤素，烷基 氟烷基，甲酰基，烷氧基羰基，酰基，羟基，烷氧基，酰氧基，糖氧基，氨基，烷基氨基，巯基，烷硫基和硝基; B表示单键或含有1-4个碳原子的直链亚烷基，其可以具有至少一个选自烷基，芳基，芳烷基，羟基和氧代的取代基; R表示选自氢，碱金属，碱土金属，烷基，环烷基，芳烷基和芳基的原子或基团。 并且n为2或8，或其药学上可接受的盐被包围。

    Imidazole derivatives
    5.
    发明授权
    Imidazole derivatives 失效
    咪唑衍生物

    公开(公告)号：US5180836A

    公开(公告)日：1993-01-19

    申请号：US786392

    申请日：1991-11-01

    申请人： Susumu Okabe ,  Mitsuo Masaki ,  Tomio Yamakawa ,  Hitoshi Matsukura ,  Yutaka Nomura

    发明人： Susumu Okabe ,  Mitsuo Masaki ,  Tomio Yamakawa ,  Hitoshi Matsukura ,  Yutaka Nomura

    IPC分类号： C07D233/84 ,  C07D235/28

    CPC分类号： C07D233/84 ,  C07D235/28

    摘要： Disclosed are novel imidazole derivatives having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are H, alkyl, cycloalkyl, aryl, aralkyl or halogen-substituted alkyl, or R.sup.1 and R.sup.2 are combined to form a heterocyclic ring; R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are H, halogen, alkoxy, aralkyloxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, or fluorine substituted-alkoxy, or R.sup.3 is combined with R.sup.2 to form a heterocyclic ring; R.sup.8 and R.sup.9 are H, halogen, alkoxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, fluorine substituted-alkoxy, or aryl group which may have a substituent, or R.sup.8 and R.sup.9 are combined to form an alicyclic ring; R.sup.7 is, where R.sup.8 and R.sup.9 are not combined, H, and, where R.sup.8 and R.sup.9 are combined, H, alkyl which may have a substituent, aryl which may have a substituent, arylcarbonyl which may have a substituent, or a sulfur-containing heterocyclic group; and n is 0 or 1. The new imidazole derivatives are effective particularly as anti-ulcer agents.

    摘要翻译： 公开了具有下式的新的咪唑衍生物：其中R 1和R 2是H，烷基，环烷基，芳基，芳烷基或卤素取代的烷基，或者R 1和R 2结合形成杂环; R3，R4，R5和R6是H，卤素，烷氧基，芳烷氧基，烷基，烷氧基羰基，硝基，氨基，酰基，氟取代的 - 烷基或氟取代的 - 烷氧基，或R3与R2结合形成杂环; R8和R9是可以具有取代基的H，卤素，烷氧基，烷基，烷氧基羰基，硝基，氨基，酰基，氟取代的 - 烷基，氟取代的 - 烷氧基或芳基，或R8和R9组合形成脂环 ; R 7是，其中R 8和R 9不组合，其中R 8和R 9结合，可以具有取代基的烷基，可以具有取代基的芳基，可以具有取代基的芳基或含硫 杂环基; 并且n为0或1.新的咪唑衍生物特别用作抗溃疡剂。

    Certain gastric acid secretion inhibiting sulfoxides
    8.
    发明授权
    Certain gastric acid secretion inhibiting sulfoxides 失效
    某些胃酸分泌抑制亚砜

    公开(公告)号：US4933458A

    公开(公告)日：1990-06-12

    申请号：US198086

    申请日：1988-05-24

    申请人： Susumu Okabe ,  Masaru Satoh ,  Tomio Yamakawa ,  Yutaka Nomura ,  Masatoshi Hayashi

    发明人： Susumu Okabe ,  Masaru Satoh ,  Tomio Yamakawa ,  Yutaka Nomura ,  Masatoshi Hayashi

    IPC分类号： C07D241/44 ,  C07D401/12 ,  C07D471/04

    CPC分类号： C07D401/12 ,  C07D241/44 ,  C07D471/04

    摘要： Sulfoxide derivatives having the formula (I) or (V) show a gastric acid-secretion inhibitory effect: ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen, lower alkyl, hydroxyalkyl, phenyl, phenylalkyl or cycloalkyl, R.sup.1 and R.sup.2 may form together with the adjacent N atom a heterocyclic group; each of R.sup.3, R.sup.4, R.sup.4a, R.sup.4b, R.sup.5, R.sup.6, and R.sup.7 is hydrogen, halogen, lower alkoxy, lower alkyl, trifluoromethyl, or fluorine atom-containing lower alkoxy; Y is CH or N; and Z is unsubstituted or substituted 2-pyridine or 2-aminophenyl.

    摘要翻译： 具有式（I）或（V）的亚砜衍生物显示出胃酸分泌抑制作用：其中R1和R2各自为氢，低级烷基，羟烷基，苯基，苯基烷基 或环烷基，R 1和R 2可以与相邻的N原子一起形成杂环基; R3，R4，R4a，R4b，R5，R6和R7各自为氢，卤素，低级烷氧基，低级烷基，三氟甲基或含氟原子的低级烷氧基; Y是CH或N; Z是未取代的或取代的2-吡啶或2-氨基苯基。

    Method of protecting gastrointestinal tract
    9.
    发明授权
    Method of protecting gastrointestinal tract 失效
    保护胃肠道的方法

    公开(公告)号：US4824856A

    公开(公告)日：1989-04-25

    申请号：US896154

    申请日：1986-08-13

    申请人： Susumu Okabe ,  Masaru Satoh ,  Tomio Yamakawa ,  Yutaka Nomura ,  Masatoshi Hayashi

    发明人： Susumu Okabe ,  Masaru Satoh ,  Tomio Yamakawa ,  Yutaka Nomura ,  Masatoshi Hayashi

    IPC分类号： A61K31/445 ,  C07D235/28 ,  A61K31/415

    CPC分类号： C07D235/28 ,  A61K31/445

    摘要： A method of protecting gastrointestinal tract in a mammal from the untoward, non-gastric-acid-induced effects of exposure to gastrointestinally injuruous agents, which comprises administering orally to said mammal a non-antisecretory amount of a benzimidazole derivative having the formula (I): ##STR1## wherein R.sup.1 is the hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a cycloalkyl group, phenyl group or aralkyl group, R.sup.2 is the hydrogen atom or a lower alkyl group, or R.sup.1 and R.sup.2 together with the adjacent nitrogen atom forms a ring, and each of R.sup.3 and R.sup.4 independently is the hydrogen atom, a halogen atom, the trifluoromethyl group, a lower alkyl group, a lower alkoxy group, a lower alkoxycarbonyl group or an amino group.

    摘要翻译： 一种保护哺乳动物胃肠道免受暴露于胃肠损伤药物的非胃酸，非胃酸诱导作用的方法，其包括向所述哺乳动物口服给予非抗分泌量的式（I）的苯并咪唑衍生物， ：其中R 1为氢原子，碳原子数为1〜8的烷基，环烷基，苯基或芳烷基，R 2为氢原子或低级烷基，或者R 1和R 2为一体 与相邻的氮原子形成环，R3和R4各自独立地为氢原子，卤素原子，三氟甲基，低级烷基，低级烷氧基，低级烷氧基羰基或氨基。

    Method for producing seamless tube/pipe
    10.
    发明授权
    Method for producing seamless tube/pipe 有权
    生产无缝管/管的方法

    公开(公告)号：US09254511B2

    公开(公告)日：2016-02-09

    申请号：US13991635

    申请日：2011-12-06

    申请人： Kenichi Saitou ,  Kazuhiro Shimoda ,  Tomio Yamakawa

    发明人： Kenichi Saitou ,  Kazuhiro Shimoda ,  Tomio Yamakawa

    IPC分类号： B21B21/02 ,  B21B19/04 ,  B21B25/00

    CPC分类号： B21B21/02 ,  B21B19/04 ,  B21B25/00 ,  B21B2261/08 ,  B21B2261/10

    摘要： By using a piercing mill that includes a pusher on the entrance side, a plug on the exit side along a pass line, and a plurality of angled rolls as being provided around the plug so as face to each other, in the case where the maximum diameter of an unsound region consisting of center segregation and porosity in a cross section of a billet is d [mm], piercing-rolling is performed under the condition that the plug nose rolling reduction ratio (TDF) expressed by Formula (1) satisfies Formula (2). TDF=(Bd−D1)/Bd  (1) TDF≦−0.50×(d/Bd)+0.06  (2) In Formulae (1) and (2), Bd is the billet diameter [mm], and D1 is the opening [mm] between the angled rolls at the plug nose position. Thereby, when piercing-rolling is performed, the occurrence of an inner surface flaw attributable to the center segregation and porosity in the billet can be prevented reliably.

    摘要翻译： 通过使用包括在入口侧的推动器的穿孔机，沿着通行线的出口侧的塞子和在插头周围设置成彼此面对的多个成角度的辊，在最大值 在坯料的横截面中由中心偏析和孔隙率组成的不固定区域的直径为d [mm]，在由式（1）表示的塞子前端滚动压下率（TDF）满足公式的条件下进行穿孔轧制 （2）。 TDF =（Bd-D1）/ Bd（1）TDF＆nlE; -0.50×（d / Bd）+0.06（2）在式（1）和（2）中，Bd是坯料直径[mm]，D1是 在插头前端位置的成角度的卷轴之间打开[mm]。 因此，当进行穿孔轧制时，可以可靠地防止由于中心偏析引起的内表面缺陷的发生和坯料中的孔隙率的发生。