公开(公告)号：US20210206739A1

公开(公告)日：2021-07-08

申请号：US17058574

申请日：2019-05-29

Applicant: Translate Bio, Inc.

Inventor： Yi Zhang ,  Shrirang Karve ,  Saswata Karmakar ,  Frank DeRosa ,  Michael Heartlein

IPC: C07D311/20 ,  C07C225/14 ,  C07C229/12 ,  C07C323/25 ,  C07C323/27 ,  C07C403/12

Abstract: Disclosed are cationic lipids comprising a vitamin substructure and an ionizable nitrogen-containing group. Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

公开(公告)号：US12240824B2

公开(公告)日：2025-03-04

申请号：US17058574

申请日：2019-05-29

Applicant: Translate Bio, Inc.

Inventor： Yi Zhang ,  Shrirang Karve ,  Saswata Karmakar ,  Frank DeRosa ,  Michael Heartlein

IPC: C07C401/00 ,  A61K9/127 ,  C07C225/14 ,  C07C229/12 ,  C07C323/25 ,  C07C323/27 ,  C07C403/12 ,  C07D311/20 ,  A61K31/592 ,  A61K31/593

Abstract: Disclosed are cationic lipids comprising a vitamin substructure and an ionizable nitrogen-containing group. Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

公开(公告)号：US12076439B2

公开(公告)日：2024-09-03

申请号：US17057929

申请日：2019-05-23

Applicant: Translate Bio, Inc.

Inventor： Yi Zhang ,  Shrirang Karve ,  Frank DeRosa ,  Michael Heartlein

IPC: C07C327/22 ,  A61K9/127 ,  A61K38/45 ,  A61K38/52 ,  C07C327/30 ,  C07D245/02 ,  C07D257/00

CPC classification number: A61K9/1272 ,  A61K38/45 ,  A61K38/52 ,  C07C327/22 ,  C07C327/30 ,  C07D245/02 ,  C07D257/00

Abstract: Disclosed are cationic lipids which are compounds of Formula (I), (II), (III), (IV), (V), or (VI). Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

公开(公告)号：US12064515B2

公开(公告)日：2024-08-20

申请号：US17737712

申请日：2022-05-05

Applicant: Translate Bio, Inc.

Inventor： Shrirang Karve ,  Zarna Patel ,  Yi Zhang ,  Ashish Sarode ,  Rebecca L. Goldman ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K9/51 ,  A61K9/127 ,  A61K9/14 ,  A61K31/7105

CPC classification number: A61K9/1277 ,  A61K9/141 ,  A61K9/51 ,  A61K31/7105

Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.

公开(公告)号：US20230071228A1

公开(公告)日：2023-03-09

申请号：US17291937

申请日：2019-11-07

Applicant: Translate Bio, Inc.

Inventor： Yi Zhang ,  Frank DeRosa ,  Shrirang Karve ,  Michael Heartlein ,  Saswata Karmakar ,  Ryan Landis

IPC: C07D241/04 ,  A61K47/24 ,  A61K31/7105 ,  A61K9/127

Abstract: The present invention provides, in part, cyclic amino acid lipid compounds of formula (A′), and sub-formulas thereof or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

公开(公告)号：US11530298B2

公开(公告)日：2022-12-20

申请号：US16621045

申请日：2018-06-11

Applicant: TRANSLATE BIO, INC.

Inventor： Frank DeRosa ,  Michael Heartlein ,  Shrirang Karve ,  Yi Zhang

IPC: C08G79/04 ,  A61K38/53 ,  A61K47/34 ,  C08F293/00 ,  A61K31/7088

Abstract: Disclosed are polymers comprising the moiety A, which is a moiety of formula I: and pharmaceutically acceptable salts thereof, wherein R, R1, R2, L, n1 and n2 are as defined herein. These polymers are useful for delivering nucleic acids to subject. These polymers and pharmaceutically acceptable compositions comprising such polymers and nucleic acids can be useful for treating various diseases, disorders and conditions.

公开(公告)号：US20220347307A1

公开(公告)日：2022-11-03

申请号：US17705803

申请日：2022-03-28

Applicant: Translate Bio, Inc.

Inventor： Shrirang Karve ,  Zarna Patel ,  Ashish Sarode ,  Yi Zhang ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K47/64 ,  A61K47/54 ,  A61K47/69 ,  A61K31/7105 ,  C12N15/85

Abstract: The present invention provides, among other things, methods and compositions of formulating nucleic acid-containing nanoparticles for efficient delivery of payload in vivo such that the method and compositions can be used to generate mRNA vaccines.

公开(公告)号：US20220008338A1

公开(公告)日：2022-01-13

申请号：US17057929

申请日：2019-05-23

Applicant: Translate Bio, Inc.

Inventor： Yi Zhang ,  Shrirang Karve ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K9/127 ,  C07C327/22 ,  C07D257/00 ,  A61K38/52 ,  A61K38/45

Abstract: Disclosed are cationic lipids which are compounds of Formula (I), (II), (III), (IV), (V), or (VI). Cationic lipids provided herein can be useful for delivery and expression of mRNA and encoded protein, e.g., as a component of liposomal delivery vehicle, and accordingly can be useful for treating various diseases, disorders and conditions, such as those associated with deficiency of one or more proteins.

公开(公告)号：US20200277446A1

公开(公告)日：2020-09-03

申请号：US16621045

申请日：2018-06-11

Applicant: TRANSLATE BIO, INC.

Inventor： Frank DeRosa ,  Michael Heartlein ,  Shrirang Karve ,  Yi Zhang

IPC: C08G79/04 ,  C08F293/00 ,  A61K47/34 ,  A61K38/53

Abstract: Disclosed are polymers comprising the moiety A, which is a moiety of formula I: and pharmaceutically acceptable salts thereof, wherein R, R1, R2, L, n1 and n2 are as defined herein. These polymers are useful for delivering nucleic acids to subject. These polymers and pharmaceutically acceptable compositions comprising such polymers and nucleic acids can be useful for treating various diseases, disorders and conditions.

公开(公告)号：US20200085745A1

公开(公告)日：2020-03-19

申请号：US16553747

申请日：2019-08-28

Applicant: Translate Bio, Inc.

Inventor： Shrirang Karve ,  Zarna Patel ,  Yi Zhang ,  Ashish Sarode ,  Rebecca L. Ball ,  Frank DeRosa ,  Michael Heartlein

IPC: A61K9/127 ,  A61K9/14 ,  A61K9/51 ,  A61K31/7105

Abstract: The present invention provides an improved process for lipid nanoparticle formulation and mRNA encapsulation. In some embodiments, the present invention provides a process of encapsulating messenger RNA (mRNA) in lipid nanoparticles comprising a step of mixing a solution of pre-formed lipid nanoparticles and mRNA at a low concentration.