公开(公告)号：US20130245229A1

公开(公告)日：2013-09-19

申请号：US13709055

申请日：2012-12-09

Applicant: UCB PHARMA S.A.

Inventor： Ralph Adams ,  Andrew George Popplewell ,  Stephen Edward Rapecki ,  Simon Peter Tickle

IPC: C07K16/46 ,  A61K47/48

CPC classification number: C07K16/244 ,  A61K47/48215 ,  A61K47/60 ,  A61K2039/505 ,  C07K16/464 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention relates to an antibody molecule having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecule and methods for producing said antibody molecule.

公开(公告)号：US20200157204A1

公开(公告)日：2020-05-21

申请号：US16717671

申请日：2019-12-17

Applicant: UCB PHARMA S.A.

Inventor： David Paul Humphreys ,  Ralph Adams ,  James Heads ,  Shirley Jane Peters

IPC: C07K16/24 ,  A61K39/395 ,  C07K16/00

Abstract: The present invention provides an antibody of the class IgG4 comprising at least one heavy chain which comprises a CH1 domain and a hinge region, wherein in each heavy chain: a. the inter-chain cysteine at position 127, numbered according to the Kabat numbering system, in the CH1 domain is substituted with another amino acid; and b. one or more of the amino acids positioned in the upper hinge region is substituted with cysteine.

公开(公告)号：US09631015B2

公开(公告)日：2017-04-25

申请号：US14795374

申请日：2015-07-09

Applicant: UCB Pharma S.A.

Inventor： Richard Evan Gelinas ,  Mitra Choudhury Singhal ,  Yi Zhang ,  Andrew George Popplewell ,  Ralph Adams

IPC: A61K39/395 ,  C07K16/24 ,  A61K39/00

CPC classification number: A61K39/3955 ,  A61K2039/505 ,  C07K16/248 ,  C07K2316/96 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/11

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：US09040048B2

公开(公告)日：2015-05-26

申请号：US13672077

申请日：2012-11-08

Applicant: UCB PHARMA S.A.

Inventor： Ralph Adams ,  Pallavi Bhatta ,  Sam Philip Heywood ,  David Paul Humphreys

IPC: A61K39/395 ,  C07K14/705 ,  C07K16/28 ,  C07K16/18 ,  A61K39/00

CPC classification number: C07K16/18 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/2866 ,  C07K16/2878 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of human OX40, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

Abstract translation: 本发明涉及对人OX40的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。

公开(公告)号：US20140044732A1

公开(公告)日：2014-02-13

申请号：US14035053

申请日：2013-09-24

Applicant: UCB Pharma S.A.

Inventor： Ralph Adams ,  Andrew George Popplewell ,  Stephen Edward Rapecki

IPC: C07K16/24

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.