公开(公告)号：US08013163B2

公开(公告)日：2011-09-06

申请号：US11814458

申请日：2006-01-20

申请人： Paul Graham Wyatt ,  David Charles Rees ,  Mladen Vinkovic ,  Gary Trewartha

发明人： Paul Graham Wyatt ,  David Charles Rees ,  Mladen Vinkovic ,  Gary Trewartha

IPC分类号： C07D401/00 ,  A61K31/445

CPC分类号： C07D231/40 ,  C07D401/12

摘要： The invention provides an acid addition salt of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and crystals thereof, the salt being formed with an acid selected from methanesulphonic acid and acetic acid and mixtures thereof. Also provided are the novel uses of salts of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide, processes for the preparation of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and its salts and novel chemical intermediates.

摘要翻译： 本发明提供4-（2,6-二氯 - 苯甲酰基氨基）-1H-吡唑-3-羧酸哌啶-4-基酰胺及其晶体的酸加成盐，该盐由选自甲磺酸和乙酸的酸形成 酸及其混合物。 还提供了4-（2,6-二氯 - 苯甲酰基氨基）-1H-吡唑-3-羧酸哌啶-4-基酰胺的盐的新用途，制备4-（2,6-二氯 - 苯甲酰基氨基 ）-1H-吡唑-3-羧酸哌啶-4-基酰胺及其盐和新的化学中间体。