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64 条记录 (耗时 0.239 秒)

    .alpha.-(4-Biphenylyl)-benzyl-azolium salts and their use for combating micro-organisms
    25.
    发明授权
    .alpha.-(4-Biphenylyl)-benzyl-azolium salts and their use for combating micro-organisms 失效
    α-（4-联苯基） - 苄基 - 唑烷鎓盐及其用于抗微生物的用途

    公开(公告)号：US4243670A

    公开(公告)日：1981-01-06

    申请号：US14783

    申请日：1979-02-23

    申请人： Erik Regel ,  Wilfried Draber ,  Karl H. Buchel ,  Manfred Plempel

    发明人： Erik Regel ,  Wilfried Draber ,  Karl H. Buchel ,  Manfred Plempel

    IPC分类号： C08G69/48 ,  A61K31/41 ,  A61K31/415 ,  A61P31/04 ,  A61P31/10 ,  C07D233/56 ,  C07D233/58 ,  C07D233/60 ,  C07D249/08 ,  C07D521/00 ,  C08G69/00 ,  A01N43/26 ,  A01N43/28

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： The present invention relates to novel .alpha.-(4-biphenylyl)-benzyl-azolium salts of the general formula ##STR1## in which A represents the CH group or a N atomR.sup.1 and R.sup.2 are identical or different and each represents hydrogen, alkyl or optionally substituted phenyl,R.sup.3 represents hydrogen, alkyl, or an optionally substituted phenyl, phenylalkyl, phenylcarbonyl or phenylcarbonylalkyl group,X represents halogen, alkyl, halogenoalkyl, alkoxy, alkylthio, nitro or cyano,Y represents X or optionally substituted phenyl,m and n each represents 0 or an integer from1 to 5 andZ represents the anion of an inorganic or organic acid.The invention also includes processes for the preparation of the compounds and, in addition includes compositions containing the compounds and methods for their use. The compounds of the invention exhibit antimicrobial activity and sporicidal activity.

    摘要翻译： 本发明涉及其中A表示CH基团或N原子R1和R2相同或不同并且各自表示氢的通式为“IMA”（I）的新型α-（4-联苯基） - 苄基 - ，烷基或任选取代的苯基，R 3表示氢，烷基或任选取代的苯基，苯基烷基，苯基羰基或苯基羰基烷基，X表示卤素，烷基，卤代烷基，烷氧基，烷硫基，硝基或氰基，Y表示X或任选取代的苯基， m和n各自表示0或1至5的整数，Z表示无机或有机酸的阴离子。 本发明还包括制备化合物的方法，并且还包括含有这些化合物的组合物及其使用方法。 本发明的化合物显示出抗微生物活性和杀孢子活性。

    N-methyl-imidazole derivatives as anti-mycotic agents
    27.
    发明授权
    N-methyl-imidazole derivatives as anti-mycotic agents 失效
    N-甲基 - 咪唑衍生物作为抗真菌剂

    公开(公告)号：US3934014A

    公开(公告)日：1976-01-20

    申请号：US474873

    申请日：1974-05-31

    申请人： Wilfried Draber ,  Karl Heinz Buchel ,  Erik Regel ,  Manfred Plempel

    发明人： Wilfried Draber ,  Karl Heinz Buchel ,  Erik Regel ,  Manfred Plempel

    IPC分类号： A61K31/495 ,  A61K31/505 ,  C07D241/12 ,  C07D403/06

    CPC分类号： C07D403/06 ,  A61K31/495 ,  A61K31/505 ,  C07D241/12

    摘要： N-methyl-imidazole derivatives of the formula: ##EQU1## or a pharmaceutically acceptable non-toxic salt thereof, wherein X is an unsubstituted or substituted 6-membered heteroaromatic moiety having two nitro heteroatoms,Y is an unsubstituted or substituted aliphatic moiety, an unsubstituted or substituted cycloaliphatic moiety, an unsubstituted or substituted aralkyl moiety or an unsubstituted or substituted aryl moiety, andZ is an unsubstituted or substituted aliphatic moiety, an unsubstituted or substituted cycloaliphatic moiety, an unsubstituted or substituted aralkyl moiety, an unsubstituted or substituted aryl moiety, an unsubstituted or substituted pyridyl moiety or an alkoxycarbonyl moiety,Are useful as antimycotic agents.

    摘要翻译： 其中X是具有两个硝基杂原子的未取代或取代的6元杂芳族部分，Y是一个 未取代或取代的脂族部分，未取代或取代的脂环族部分，未取代或取代的芳烷基部分或未取代或取代的芳基部分，Z为未取代或取代的脂族部分，未取代或取代的脂环族部分，未取代或取代的芳烷基部分 ，未取代或取代的芳基部分，未取代或取代的吡啶基部分或烷氧基羰基部分，可用作抗生药剂。

    Disubstituted triphenylmethylimidazoles
    30.
    发明授权
    Disubstituted triphenylmethylimidazoles 失效
    分离的三苯基甲基咪唑

    公开(公告)号：US4052409A

    公开(公告)日：1977-10-04

    申请号：US339430

    申请日：1973-03-08

    申请人： Karl Heinz Buchel ,  Erik Regel ,  Manfred Plempel

    发明人： Karl Heinz Buchel ,  Erik Regel ,  Manfred Plempel

    IPC分类号： C07D233/62 ,  C07D521/00

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： Imidazoles of the formula ##STR1## and pharmaceutically acceptable nontoxic salts thereof, wherein X is methyl or chloro,Y is methyl or chloro, or, when Z is methyl or chloro, Y is hydrogen, andZ is methyl or chloro, or, when Y is methyl or chloro, Z is hydrogen,Are useful as antimycotics for the treatment of mycotic infections in humans and animals. The imidazoles may be produced by reacting the corresponding triphenylmethylcarbinol with a brominating or chlorinating agent and thereafter reacting the resultant triphenylmethyl halide, either with or without isolation, with imidazole in the presence or absence of an acid-binding agent, or they may be prepared by reacting a triphenylmethyl halide with imidazole, either in the presence or absence of an acid-binding agent.