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公开(公告)号:US20130196971A1
公开(公告)日:2013-08-01
申请号:US13823931
申请日:2011-09-15
申请人: Christopher Joseph Aquino , Dennis Heyer , Terence John Kiesow , David Lee Musso , Cynthia A. Parrish
发明人: Christopher Joseph Aquino , Dennis Heyer , Terence John Kiesow , David Lee Musso , Cynthia A. Parrish
IPC分类号: C07D403/06 , C07D471/04 , C07D401/14 , C07D403/14 , C07D405/14
CPC分类号: C07D403/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要: This invention relates to the use of imidazole, triazole, and tetrazole derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of imidazoles, triazoles, and tetrazoles in the treatment of cancer.
摘要翻译: 本发明涉及咪唑,三唑和四唑衍生物用于调节,特别是抑制脂肪酸合酶(FAS)活性或功能的用途。 合适地,本发明涉及咪唑,三唑和四唑在治疗癌症中的用途。
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公开(公告)号:US20100204222A1
公开(公告)日:2010-08-12
申请号:US12678397
申请日:2008-09-17
IPC分类号: A61K31/519 , C07D471/04 , C07D413/14 , A61K31/5377 , A61P9/00 , A61P25/28 , A61P37/08 , A61P11/06 , A61P1/18 , A61P13/12 , A61P15/08 , A61P37/06
CPC分类号: C07D471/04
摘要: Invented is a method of inhibiting the activity/function of PI3 kinases using pyridopyrimidine derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of pyridopyrimidine derivatives.
摘要翻译: 本发明是使用吡啶并嘧啶衍生物抑制PI3激酶的活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法:自身免疫性疾病,炎性疾病,心血管疾病,神经变性疾病,变态反应,哮喘,胰腺炎,多器官功能衰竭,肾脏疾病,血小板聚集,癌症,精子活力,移植排斥反应, 通过施用吡啶并嘧啶衍生物的移植排斥和肺损伤。
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23.
公开(公告)号:US20120295915A1
公开(公告)日:2012-11-22
申请号:US13511767
申请日:2010-11-22
申请人: Amita M. Chaudhari , Jason Hallman , Christopher P. Laudeman , David Lee Musso , Cynthia A. Parrish
发明人: Amita M. Chaudhari , Jason Hallman , Christopher P. Laudeman , David Lee Musso , Cynthia A. Parrish
IPC分类号: C07D401/14 , A61P35/02 , A61K31/52 , A61P35/00 , A61K31/437 , C07D473/40
CPC分类号: C07D471/04 , C07D473/00 , C07D473/34 , C07D473/40 , C07D519/00
摘要: Disclosed are compounds having Formula (I), wherein R1, R2, R3, R4, Ra, Rb, X, Y, m, and n are defined herein and methods of using the same.
摘要翻译: 公开了具有式(I)的化合物,其中R 1,R 2,R 3,R 4,R a,R b,X,Y,m和n如本文所定义,以及使用该化合物的方法。
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公开(公告)号:US07592342B2
公开(公告)日:2009-09-22
申请号:US12117127
申请日:2008-05-08
IPC分类号: A61K31/498
CPC分类号: C07D471/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D417/14
摘要: Invented is a method of inhibiting the activity/function of PI3 kinases using quinoxaline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoxaline derivatives.
摘要翻译: 发明的是使用喹喔啉衍生物抑制PI3激酶活性/功能的方法。 还发明了一种治疗选自以下的一种或多种疾病状态的方法:自身免疫性疾病,炎性疾病,心血管疾病,神经变性疾病,变态反应,哮喘,胰腺炎,多器官功能衰竭,肾脏疾病,血小板聚集,癌症,精子活力,移植排斥反应, 通过施用喹喔啉衍生物的移植排斥和肺部损伤。
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