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公开(公告)号：US07311922B1
公开(公告)日：2007-12-25
申请号：US09688672
申请日：2000-10-10
申请人： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
发明人： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
IPC分类号： A61K39/08 , A61K39/02 , A61K39/40 , A61K39/395
CPC分类号： A61K39/04 , A61K39/00 , A61K2039/53 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6031 , C07K14/35 , C07K2319/00
摘要： The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌种抗原的融合蛋白。 具体地说，本发明涉及编码融合蛋白的核酸，其包括两种或多种单个的结核分枝杆菌抗原，其增加来自感染结核病的个体的血清的血清学敏感性，及其用于诊断，治疗和预防结核病感染的方法 。
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公开(公告)号：US07976844B2
公开(公告)日：2011-07-12
申请号：US11418848
申请日：2006-05-05
申请人： Yasir Skeiky , Steven Reed , Mark Alderson
发明人： Yasir Skeiky , Steven Reed , Mark Alderson
CPC分类号： C07K14/35 , A61K39/00 , A61K39/04 , A61K2039/53 , A61K2039/55505 , A61K2039/55566 , C07K2319/00
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这些组合物的核酸和融合蛋白。 本发明的组合物增加来自感染结核病的个体的血清的血清学敏感性，以及用于诊断，治疗和预防结核病感染的方法。
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公开(公告)号：US07973153B2
公开(公告)日：2011-07-05
申请号：US11981142
申请日：2007-10-30
申请人： Yasir Skeiky , Steven Reed , Mark Alderson
发明人： Yasir Skeiky , Steven Reed , Mark Alderson
CPC分类号： C07K14/35 , A61K39/00 , A61K39/04 , A61K2039/53 , A61K2039/55505 , A61K2039/55566 , C07K2319/00
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这些组合物的核酸和融合蛋白。 本发明的组合物增加来自感染结核病的个体的血清的血清学敏感性，以及用于诊断，治疗和预防结核病感染的方法。
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公开(公告)号：US20090004226A1
公开(公告)日：2009-01-01
申请号：US11980961
申请日：2007-10-30
申请人： Yasir Skeiky , Steven Reed , Mark Alderson
发明人： Yasir Skeiky , Steven Reed , Mark Alderson
CPC分类号： C07K14/35 , A61K39/00 , A61K39/04 , A61K2039/53 , A61K2039/55505 , A61K2039/55566 , C07K2319/00
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这些组合物的核酸和融合蛋白。 本发明的组合物增加来自感染结核病的个体的血清的血清学敏感性，以及用于诊断，治疗和预防结核病感染的方法。
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公开(公告)号：US07261897B2
公开(公告)日：2007-08-28
申请号：US11396117
申请日：2006-03-30
申请人： Yasir Skeiky , Steven Reed , Mark Alderson
发明人： Yasir Skeiky , Steven Reed , Mark Alderson
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , C07K2319/00
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这些组合物的核酸和融合蛋白。 本发明的组合物增加来自感染结核病的个体的血清的血清学敏感性，以及用于诊断，治疗和预防结核病感染的方法。
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公开(公告)号：US07083796B2
公开(公告)日：2006-08-01
申请号：US09886349
申请日：2001-06-20
申请人： Yasir Skeiky , Steven Reed , Mark Alderson
发明人： Yasir Skeiky , Steven Reed , Mark Alderson
CPC分类号： C07K14/35 , A61K39/00 , A61K39/04 , A61K2039/53 , A61K2039/55505 , A61K2039/55566 , C07K2319/00
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
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公开(公告)号：US07982025B2
公开(公告)日：2011-07-19
申请号：US11809102
申请日：2007-05-30
申请人： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
发明人： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
CPC分类号： A61K39/04 , A61K39/00 , A61K2039/53 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6031 , C07K14/35 , C07K2319/00
摘要： The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
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公开(公告)号：US20090306195A1
公开(公告)日：2009-12-10
申请号：US12490984
申请日：2009-06-24
申请人： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
发明人： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
IPC分类号： A61K31/7088
CPC分类号： A61K39/04 , A61K39/00 , A61K2039/53 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6031 , C07K14/35 , C07K2319/00
摘要： The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌种抗原的融合蛋白。 具体地说，本发明涉及编码融合蛋白的核酸，其包括两种或多种单个的结核分枝杆菌抗原，其增加来自感染结核病的个体的血清的血清学敏感性，及其用于诊断，治疗和预防结核病感染的方法 。
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公开(公告)号：US20080317716A1
公开(公告)日：2008-12-25
申请号：US11981459
申请日：2007-10-30
申请人： Yasir Skeiky , Steven Reed , Mark Alderson
发明人： Yasir Skeiky , Steven Reed , Mark Alderson
CPC分类号： C07K14/35 , A61K39/00 , A61K39/04 , A61K2039/53 , A61K2039/55505 , A61K2039/55566 , C07K2319/00
摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
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公开(公告)号：US20080269151A1
公开(公告)日：2008-10-30
申请号：US11809102
申请日：2007-05-30
申请人： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
发明人： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
IPC分类号： A61K31/7088 , A61P31/06
CPC分类号： A61K39/04 , A61K39/00 , A61K2039/53 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6031 , C07K14/35 , C07K2319/00
摘要： The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌种抗原的融合蛋白。 具体地说，本发明涉及编码融合蛋白的核酸，其包括两种或多种单个的结核分枝杆菌抗原，其增加来自感染结核病的个体的血清的血清学敏感性，及其用于诊断，治疗和预防结核病感染的方法 。
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