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1.发明申请COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF INFLAMMATORY BOWEL DISEASE 有权炎症性皮肤疾病治疗和诊断的组合物和方法公开(公告)号：US20120039924A1
公开(公告)日：2012-02-16
申请号：US13092888
申请日：2011-04-22
IPC分类号： A61K39/02 , C07K17/00 , C07K19/00 , A61P31/04 , G01N33/566 , C12Q1/68 , A61P37/04 , A61P1/00 , C07K14/195 , C07H21/04
CPC分类号： C07K16/1232 , A61K38/00 , A61K39/00 , A61K39/40 , A61K45/06 , A61K2039/505 , A61K2039/523 , A61K2039/53 , C07K14/001 , C07K14/195 , C07K14/205 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/00 , G01N33/505 , G01N33/6893 , G01N2800/065
摘要： Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
摘要翻译： 公开了用于治疗和诊断炎症性肠病（IBD）的组合物和方法，包括克罗恩病和溃疡性结肠炎。 说明性组合物包含一种或多种细菌多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如IBD的诊断，预防和/或治疗。
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公开(公告)号：US20080199405A1
公开(公告)日：2008-08-21
申请号：US11801112
申请日：2007-05-07
申请人： Steven G. Reed , Yasir A.W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
发明人： Steven G. Reed , Yasir A.W. Skeiky , Davin C. Dillon , Antonio Campos-Neto , Raymond Houghton , Thomas S. Vedvick , Daniel R. Twardzik , Michael J. Lodes , Ronald C. Hendrickson
IPC分类号： A61K39/00 , A61K31/70 , A61K49/00 , C07K14/00 , C12N1/00 , C12N15/00 , C12N5/06 , C12N15/11 , C12N1/20 , C12M1/34 , A61P43/00 , A61K38/00
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00
摘要： Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
摘要翻译： 公开了诱导针对结核病的保护性免疫的化合物和方法。 提供的化合物包括含有至少一种免疫原性部分的一种或多种结核分枝杆菌蛋白质和编码这种多肽的DNA分子的多肽。 这些化合物可以配制成针对结核分枝杆菌感染免疫的疫苗和/或药物组合物，或可用于诊断结核病。
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公开(公告)号：US06468758B1
公开(公告)日：2002-10-22
申请号：US09397787
申请日：1999-09-16
IPC分类号： G01N33574
CPC分类号： C12Q1/6886
摘要： Compositions and methods for the therapy and diagnosis of cancer, such as ovarian cancer, are disclosed. Compositions may comprise one or more ovarian carcinoma proteins, immunogenic portions thereof, polynucleotides that encode such portions or antibodies or immune system cells specific for such proteins. Such compositions may be used, for example, for the prevention and treatment of diseases such as ovarian cancer. Methods are further provided for identifying tumor antigens that are secreted from ovarian carcinomas and/or other tumors. Polypeptides and polynucleotides as provided herein may further be used for the diagnosis and monitoring of ovarian cancer.
摘要翻译： 公开了用于治疗和诊断癌症的组合物和方法，例如卵巢癌。 组合物可以包含一种或多种卵巢癌蛋白，其免疫原性部分，编码这种部分的多核苷酸或对这些蛋白质特异的抗体或免疫系统细胞。 这样的组合物可用于例如预防和治疗诸如卵巢癌的疾病。 还提供了用于鉴定从卵巢癌和/或其他肿瘤分泌的肿瘤抗原的方法。 本文提供的多肽和多核苷酸还可用于诊断和监测卵巢癌。
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公开(公告)号：US06306396B1
公开(公告)日：2001-10-23
申请号：US08723142
申请日：1996-10-01
IPC分类号： A61K39018
CPC分类号： C07K14/44 , A61K38/00 , A61K39/00 , C07K2319/00 , Y02A50/401 , Y02A50/403
摘要： Compounds and methods for the diagnosis and treatment of B. microti infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a B. microti antigen and DNA sequences encoding such polypeptides. Antigenic epitopes of such antigens are also provided, together with pharmaceutical compositions and vaccines comprising such polypeptides, DNA sequences or antigenic epitopes. Diagnostic kits containing such polypeptides, DNA sequences or antigenic epitopes and a suitable detection reagent may be used for the detection of B. microti infection in patients and biological samples. Antibodies directed against such polypeptides and antigenic epitopes are also provided.
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5.发明授权Compounds and methods for the diagnosis and treatment of ehrlichia infection 失效用于诊断和治疗埃里希病毒感染的化合物和方法公开(公告)号：US06231869B1
公开(公告)日：2001-05-15
申请号：US08821324
申请日：1997-03-21
IPC分类号： A61K3902
CPC分类号： C07K14/29 , A61K38/00 , C07K2319/00 , Y02A50/401
摘要： Compounds and methods for the diagnosis and treatment of Ehrlichia infection, in particular human granulocytic ehrlichiosis, are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of an Ehrlichia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Ehrlichia infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.
摘要翻译： 公开了用于诊断和治疗埃里巴病毒感染，特别是人粒细胞性肾病的化合物和方法。 提供的化合物包括含有至少一种抗原部分的埃里希抗原的多肽和编码这种多肽的DNA序列。 也提供了包含这种多肽或DNA序列的药物组合物和疫苗。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的埃氏体感染。 也提供了针对这种多肽的抗体。
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公开(公告)号：US09290543B2
公开(公告)日：2016-03-22
申请号：US12036588
申请日：2008-02-25
发明人： Robert M. Hershberg , Nancy Ann Hosken , Michael J. Lodes , Raodoh Mohamath , Stephan R. Targan
IPC分类号： G01N33/50 , C07K14/195 , C07K14/205 , A61K38/00 , A61K39/00 , C07K14/00 , G01N33/68
CPC分类号： C07K16/1232 , A61K38/00 , A61K39/00 , A61K39/40 , A61K45/06 , A61K2039/505 , A61K2039/523 , A61K2039/53 , C07K14/001 , C07K14/195 , C07K14/205 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/00 , G01N33/505 , G01N33/6893 , G01N2800/065
摘要： Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
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7.发明授权Compositions and methods for the therapy and diagnosis of inflammatory bowel disease 有权用于治疗和诊断炎症性肠病的组合物和方法公开(公告)号：US08318901B2
公开(公告)日：2012-11-27
申请号：US13092888
申请日：2011-04-22
CPC分类号： C07K16/1232 , A61K38/00 , A61K39/00 , A61K39/40 , A61K45/06 , A61K2039/505 , A61K2039/523 , A61K2039/53 , C07K14/001 , C07K14/195 , C07K14/205 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/00 , G01N33/505 , G01N33/6893 , G01N2800/065
摘要： Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
摘要翻译： 公开了用于治疗和诊断炎症性肠病（IBD）的组合物和方法，包括克罗恩病和溃疡性结肠炎。 说明性组合物包含一种或多种细菌多肽，其免疫原性部分，编码该多肽的多核苷酸，表达此类多肽的抗原呈递细胞，以及对表达该多肽的细胞特异的T细胞。 所公开的组合物可用于例如IBD的诊断，预防和/或治疗。
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公开(公告)号：US08067016B2
公开(公告)日：2011-11-29
申请号：US12490984
申请日：2009-06-24
申请人： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
发明人： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
CPC分类号： A61K39/04 , A61K39/00 , A61K2039/53 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6031 , C07K14/35 , C07K2319/00
摘要： The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌种抗原的融合蛋白。 具体地说，本发明涉及编码融合蛋白的核酸，其包括两种或多种单个的结核分枝杆菌抗原，其增加来自感染结核病的个体的血清的血清学敏感性，及其用于诊断，治疗和预防结核病感染的方法 。
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公开(公告)号：US07311922B1
公开(公告)日：2007-12-25
申请号：US09688672
申请日：2000-10-10
申请人： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
发明人： Yasir Skeiky , Steven Reed , Raymond L. Houghton , Patricia D. McNeill , Davin C. Dillon , Michael J. Lodes
IPC分类号： A61K39/08 , A61K39/02 , A61K39/40 , A61K39/395
CPC分类号： A61K39/04 , A61K39/00 , A61K2039/53 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/6031 , C07K14/35 , C07K2319/00
摘要： The present invention relates to fusion proteins containing at least two Mycobacterium species antigens. In particular, it relates to nucleic acids encoding fusion proteins that include two or more individual M. tuberculosis antigens, which increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.
摘要翻译： 本发明涉及含有至少两种分枝杆菌种抗原的融合蛋白。 具体地说，本发明涉及编码融合蛋白的核酸，其包括两种或多种单个的结核分枝杆菌抗原，其增加来自感染结核病的个体的血清的血清学敏感性，及其用于诊断，治疗和预防结核病感染的方法 。
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公开(公告)号：US06759508B2
公开(公告)日：2004-07-06
申请号：US09854133
申请日：2001-05-11
IPC分类号： C07K14435
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K2319/00 , Y02A50/396
摘要： Compositions and methods for the therapy and diagnosis of cancer, particularly lung cancer, are disclosed. Illustrative compositions comprise one or more lung tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly lung cancer.
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