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    Novel method for preventing or treating M tuberculosis infection
    5.
    发明申请
    Novel method for preventing or treating M tuberculosis infection 有权
    用于预防或治疗结核分枝杆菌感染的新方法

    公开(公告)号：US20090123491A1

    公开(公告)日：2009-05-14

    申请号：US11912730

    申请日：2006-04-27

    Applicant: Rhea Coler ,  Yves Lobet ,  Steven Reed

    Inventor： Rhea Coler ,  Yves Lobet ,  Steven Reed

    IPC: A61K39/04 ,  A61K31/7088 ,  A61P37/04

    CPC classification number: A61K39/04 ,  A61K31/4409 ,  A61K31/496 ,  A61K2039/523 ,  A61K2039/53 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/575 ,  C07K14/35

    Abstract: The present invention is directed to methods of preventing reactivation of active and latent M. tuberculosis infections by administering a pharmaceutical composition comprising a nucleic acid encoding a Mtb72f fusion protein, or a Mtb72f fusion protein or an immunogenic fragment thereof, for example together with an adjuvant. The Mtb72f nucleic acid or fusion protein can be administered with one or more chemotherapeutic agents effective against a M. tuberculosis infection. The methods also provide for shortening the time course of a chemotherapeutic regimen against a M. tuberculosis infection.

    Abstract translation: 本发明涉及通过施用包含编码Mtb72f融合蛋白或Mtb72f融合蛋白或其免疫原性片段的核酸的药物组合物，例如与佐剂一起施用来防止活性和潜伏性结核分枝杆菌感染的再活化的方法 。 Mtb72f核酸或融合蛋白可以与一种或多种对结核分枝杆菌感染有效的化学治疗剂一起施用。 所述方法还提供了缩短化疗方案针对结核分枝杆菌感染的时间过程。

    Fusion proteins of mycobacterium tuberculosis
    8.
    发明授权
    Fusion proteins of mycobacterium tuberculosis 有权
    结核分枝杆菌的融合蛋白

    公开(公告)号：US07261897B2

    公开(公告)日：2007-08-28

    申请号：US11396117

    申请日：2006-03-30

    Applicant: Yasir Skeiky ,  Steven Reed ,  Mark Alderson

    Inventor： Yasir Skeiky ,  Steven Reed ,  Mark Alderson

    IPC: A61K39/00 ,  A61K39/04 ,  A61K38/00 ,  C12N1/12 ,  C07K1/00

    CPC classification number: C07K14/35 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00

    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and nucleic acids encoding such compositions and fusion proteins. The compositions of the invention increase serological sensitivity of sera from individuals infected with tuberculosis, and methods for their use in the diagnosis, treatment, and prevention of tuberculosis infection.

    Abstract translation: 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这些组合物的核酸和融合蛋白。 本发明的组合物增加来自感染结核病的个体的血清的血清学敏感性，以及用于诊断，治疗和预防结核病感染的方法。

    Iontophoresis apparatus and method for the diagnosis of tuberculosis
    9.
    发明申请
    Iontophoresis apparatus and method for the diagnosis of tuberculosis 审中-公开
    离子电渗疗法及结核病诊断方法

    公开(公告)号：US20070081944A1

    公开(公告)日：2007-04-12

    申请号：US11540491

    申请日：2006-09-28

    Applicant: Steven Reed

    Inventor： Steven Reed

    IPC: A61K49/00 ,  G01N33/554 ,  G01N33/569 ,  A61N1/30

    CPC classification number: A61N1/0448 ,  A61N1/0436 ,  A61N1/0444 ,  C07K14/35

    Abstract: An iontophoresis device includes an active electrode assembly including an active electrode element and at least one active agent reservoir. Active agents include one or more polypeptides, or fusion polypeptides, having antigenic determinants derived from or related to M. tuberculosis antigens and suitable for detection of tuberculosis.

    Abstract translation: 离子电渗装置包括有源电极组件，其包括有源电极元件和至少一个活性剂储存器。 活性剂包括一种或多种多肽或融合多肽，其具有衍生自或与结核分枝杆菌抗原相关或适合于检测结核病的抗原决定簇。

    Fabric display with reverse bend fabric arm
    10.
    发明授权
    Fabric display with reverse bend fabric arm 失效
    织物展示与反向织物臂

    公开(公告)号：US07128127B1

    公开(公告)日：2006-10-31

    申请号：US10600265

    申请日：2003-06-20

    Applicant: Steven Reed Love ,  Jian Lou

    Inventor： Steven Reed Love ,  Jian Lou

    IPC: A47H1/00

    CPC classification number: G09F17/00 ,  A47F7/163 ,  G09F7/00 ,  G09F7/18 ,  G09F2007/1873 ,  G09F2007/1886 ,  G09F2017/0025 ,  G09F2017/0033 ,  G09F2017/0041 ,  G09F2017/005 ,  G09F2017/0066

    Abstract: A fabric display includes a fabric arm having a main segment that extends forward and terminates in a reverse bend segment at a front end of the fabric arm. A bend arm extends rearward from the reverse bend segment and is adapted to support a leading “salvage” edge of a fabric sheet that is displayed on the fabric arm so that a relatively clean “roll” edge of the fabric is presented to viewers at a front end of the fabric arm adjacent the reverse bend segment. Opposing fabric arms may be attached to a pivotable support arm to allow viewers to easily observe two separate fabric sheets supported on the opposing fabric arms.

    Abstract translation: 织物显示器包括织物臂，该织物臂具有向前延伸的主段，并终止于织物臂的前端处的反向弯曲段。 弯曲臂从反向弯曲部分向后延伸，并且适于支撑织物片上显示的织物片的领先的“补救”边缘，使得织物的相对干净的“卷”边缘呈现在观察者的一侧 织物臂的前端邻近反向弯曲段。 相对的织物臂可以附接到可枢转的支撑臂，以允许观察者容易地观察支撑在相对的织物臂上的两个分开的织物片。

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