公开(公告)号：US20180148770A1

公开(公告)日：2018-05-31

申请号：US15568818

申请日：2016-04-27

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran ELINAV ,  Eran SEGAL

IPC: C12Q1/689 ,  A61P1/00 ,  A61K31/417 ,  A61K31/132

CPC classification number: C12Q1/689 ,  A61K31/132 ,  A61K31/185 ,  A61K31/417 ,  A61P1/00 ,  G01N33/6893 ,  G01N2800/065 ,  G01N2800/52 ,  A61K2300/00

Abstract: A method of determining the therapeutic effect of an agent, such as a metabolite, comprising: (a) exposing a pathological microbiome to the agent; and (b) comparing the signature of the pathological microbiome following the exposing with a reference signature of a healthy microbiome, wherein when the signature of the microbiome is statistically significantly similar to the healthy microbiome reference signature, it is indicative that the agent has a therapeutic effect on the microbiome. The agent may be provided to a subject having a pathological microbiome once it has been classified as therapeutic.

公开(公告)号：US20160263166A1

公开(公告)日：2016-09-15

申请号：US15030650

申请日：2015-04-28

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Eran ELINAV ,  Eran SEGAL

IPC: A61K35/741 ,  C12Q1/02

CPC classification number: A61K35/741 ,  A61B5/411 ,  A61K35/66 ,  C12Q1/025 ,  C12Q1/04 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/68 ,  G01N2570/00

Abstract: A method of determining tolerance to an agent in a healthy subject is disclosed. The method comprises: (a) determining a signature of a microbiome in a sample of the healthy subject who has been subjected to the agent or condition; and (b) comparing the signature of the microbiome of the healthy subject to at least one reference signature of a pathological microbiome, wherein when the signature of the microbiome of the healthy subject is statistically significantly similar to the reference signature of the pathological microbiome, it is indicative that the healthy subject is intolerant to the agent.