公开(公告)号：US12076381B2

公开(公告)日：2024-09-03

申请号：US17576185

申请日：2022-01-14

Applicant: Immatics Biotechnologies GmbH

Inventor： Andrea Mahr ,  Toni Weinschenk ,  Oliver Schoor ,  Jens Fritsche ,  Harpreet Singh ,  Phillip Mueller ,  Julia Leibold ,  Valentina Goldfinger

IPC: A61K39/00 ,  C07K14/47 ,  C07K14/725 ,  C07K16/30 ,  C12N5/0783 ,  C12N15/115 ,  C12Q1/6886 ,  G01N33/574 ,  G01N33/68 ,  A61K38/00

CPC classification number: A61K39/0011 ,  C07K14/47 ,  C07K14/4748 ,  C07K14/7051 ,  C07K16/30 ,  C12N5/0636 ,  C12N15/115 ,  C12Q1/6886 ,  G01N33/5748 ,  G01N33/6848 ,  A61K38/00 ,  A61K2039/5158 ,  A61K2039/572 ,  C07K2319/00 ,  C12N2310/16 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57407 ,  G01N2570/00 ,  G01N2800/52

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20240287002A1

公开(公告)日：2024-08-29

申请号：US18641587

申请日：2024-04-22

Applicant: Exelixis, Inc.

Inventor： Dana T. Aftab ,  Sriram Naganathan ,  Wei Xu ,  Steven Lacy ,  Linh Nguyen

IPC: C07D215/22 ,  C07C233/60 ,  C07C305/24 ,  C07D215/60 ,  G01N33/487

CPC classification number: C07D215/22 ,  C07C233/60 ,  C07C305/24 ,  C07D215/60 ,  G01N33/487 ,  C07C2601/02 ,  G01N2570/00

Abstract: The invention relates to metabolites of cabozantinib (I) as well as uses thereof.

公开(公告)号：US12061204B2

公开(公告)日：2024-08-13

申请号：US17231977

申请日：2021-04-15

Applicant: Wisconsin Alumni Research Foundation

Inventor： Joshua Coon ,  Harald Marx

IPC: G01N33/68 ,  G16B30/00 ,  G16B30/20 ,  G16B40/00 ,  G16B40/10 ,  G16B40/30 ,  H01J49/00

CPC classification number: G01N33/6848 ,  G01N33/6824 ,  G01N33/6842 ,  G16B30/00 ,  G16B30/20 ,  G16B40/00 ,  G16B40/10 ,  G16B40/30 ,  H01J49/0036 ,  H01J49/004 ,  G01N2570/00

Abstract: In shotgun proteomics, generally only a fraction of peptides from a parent protein are actually detected. Because a large portion of the protein sequence is not detected, it is often impossible to determine whether the expressed protein is present in a modified, spliced, or truncated form. Provided herein are methods and systems for analyzing polypeptides which allow for the increase of the mean sequence coverage of a protein concomitant with bioinformatics analysis in order to distinguish putative proteoforms with improved amino acid resolution. Aspects of the invention include (1) a deep sequencing strategy to provide more protein sequence coverage than is typically achieved, and (2) a computational approach to view protein expression across its full length and identify regions of the protein that are potentially subject to such regulation. This technology has global utility in proteomics and will be of particular use for the analysis of biosimilar protein drug therapeutics.

公开(公告)号：US20240219396A1

公开(公告)日：2024-07-04

申请号：US18541906

申请日：2023-12-15

Applicant: STRECK LLC

Inventor： Matthew R. Sobansky ,  Nicholas Michael George ,  Bradford A. Hunsley ,  Sean Salamifar ,  Agnes Alicia Lenagh ,  Jing Li Oupicky ,  Nursen Binbuga

IPC: G01N33/68

CPC classification number: G01N33/6842 ,  G01N33/6848 ,  G01N2570/00

Abstract: Provided herein are methods of preparing a protein sample for proteomic analysis. In exemplary embodiments, the method comprises (a) contacting a blood sample comprising proteins with a protective agent comprising an anticoagulant (AC) and an aldehyde releaser (AR), to obtain a mixture, optionally, wherein the blood sample is added to a blood collection tube (BCT) comprising the protective agent, and (b) isolating a fraction comprising proteins or a source of proteins from the mixture to yield a protein sample or a source of a protein sample, wherein steps of the method are carried out in the absence of exogenous proteolytic enzyme inhibitors, wherein the protein sample is suitable for proteomic and peptidomedic analysis.

公开(公告)号：US12019070B2

公开(公告)日：2024-06-25

申请号：US17127402

申请日：2020-12-18

Applicant: Adeptrix Corp.

Inventor： Vladislav B. Bergo

IPC: G01N33/543 ,  G01N33/68

CPC classification number: G01N33/54306 ,  G01N33/54313 ,  G01N33/6845 ,  G01N33/6848 ,  G01N33/6878 ,  G01N2440/00 ,  G01N2570/00

Abstract: Bead-based assays for measuring protein biomarkers of proteolytic activity in biological systems are disclosed. In an embodiment, an assay involves incubating a sample containing multiple fragments of a naturally occurring protein with a bead array and subsequently analyzing individual reactive sites of the bead array by mass spectrometry.

公开(公告)号：US20240198332A1

公开(公告)日：2024-06-20

申请号：US18593787

申请日：2024-03-01

Applicant: Cellanome, Inc.

Inventor： Tarun Kumar KHURANA ,  Ali AGAH ,  Yir-Shyuan WU ,  Filiz Gorpe YASAR

IPC: B01L3/00 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N33/543 ,  G01N33/68

CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L3/502761 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N33/54386 ,  G01N33/6842 ,  B01L2200/0647 ,  B01L2200/12 ,  B01L2300/0663 ,  B01L2300/0883 ,  B01L2300/12 ,  B01L2300/163 ,  B01L2300/18 ,  C12Q2600/158 ,  G01N2570/00

Abstract: Described herein are systems and methods for analyzing biological samples. Including a method for processing an analyte, comprising providing a fluidic device comprising the analyte and one or more polymer precursors; selecting a discrete area within said fluidic device; providing an energy source in optical communication with fluidic device; and selectively supplying a unit of energy generated from the energy source to the fluidic device to generate a polymer matrix within the fluidic device, wherein the polymer matrix is within the discrete area or adjacent to the discrete area.

公开(公告)号：US11988673B2

公开(公告)日：2024-05-21

申请号：US17389757

申请日：2021-07-30

Applicant: Ventana Medical Systems, Inc.

Inventor： Michael Farrell ,  Antony Hubbard ,  Eric May ,  Lei Tang ,  Tsu-Shuen Tsao ,  Wenjun Zhang

IPC: G01N33/68 ,  C07K16/18 ,  C07K16/28 ,  C07K16/32

CPC classification number: G01N33/6878 ,  C07K16/18 ,  C07K16/2809 ,  C07K16/2815 ,  C07K16/2827 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/32 ,  C07K2319/40 ,  C07K2319/42 ,  G01N2570/00

Abstract: The present disclosure is directed to epitope-tagged antibodies, as well as methods of employing the epitope-tagged antibodies for detecting one or more targets in a biological sample, e.g. a tissue sample.

公开(公告)号：US20240052405A1

公开(公告)日：2024-02-15

申请号：US18492620

申请日：2023-10-23

Applicant: 13.8, Inc.

Inventor： Hei Mun Christina FAN ,  Stephen P.A. FODOR

IPC: C12Q1/6841 ,  C12Q1/6804 ,  G01N33/543 ,  G01N33/53

CPC classification number: C12Q1/6841 ,  C12Q1/6804 ,  G01N33/54326 ,  G01N33/5308 ,  G01N2570/00 ,  G01N2458/10

Abstract: Systems, methods, and compositions for generating a high-resolution spatial map of a distribution of targets of a sample are described. Processes for generating the spatial map can include: receiving the sample at a substrate having a distribution of functionalized particles, each having a stochastic barcode sequence paired with a position on the substrate; promoting interactions between the distribution of targets of the sample and the distribution of functionalized particles upon transmitting heat to a surface of the substrate opposite the distribution of functionalized particles; applying a set of reactions to the sample at the substrate, obtaining a set of sequences of a population of molecules generated from the set of reactions, the set of sequences associated with the distribution of targets labeled using the stochastic barcode sequences of the distribution of functionalized particles, and returning a set of positions of the distribution of targets upon processing the set of sequences.

公开(公告)号：US11899027B2

公开(公告)日：2024-02-13

申请号：US16313021

申请日：2017-07-06

Applicant: RUBIO METABOLOMICS, S.L.U.

Inventor： Ibon Martinez Arranz ,  Rebeca Mayo Sanchez ,  Azucena Castro Espido ,  Jose Maria Mato De La Paz

IPC: G01N33/92

CPC classification number: G01N33/92 ,  G01N2405/02 ,  G01N2560/00 ,  G01N2570/00 ,  G01N2800/085

Abstract: The present invention relates to methods for the diagnosis of NAFLD in a subject, and for the differential diagnosis of NASH or steatosis in a subject suffering from NAFLD, based on the determination in a sample of metabolic markers, particularly lipid metabolic markers.

公开(公告)号：US11866789B2

公开(公告)日：2024-01-09

申请号：US17411447

申请日：2021-08-25

Applicant: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE ,  MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

Inventor： Sara Byron ,  Jessica Aldrich ,  John Carpten ,  David Craig ,  Mitesh Borad ,  Alan Bryce ,  Michael Barrett ,  George Vasmatzis ,  Keith Stewart

IPC: C12Q1/6886 ,  G01N33/574 ,  A61K39/395

CPC classification number: C12Q1/6886 ,  A61K39/39558 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57496 ,  G01N2570/00 ,  G01N2800/52 ,  G01N2800/7028

Abstract: Various embodiments provide compositions and methods for detecting cancers containing an NRG1 fusion event and treating a patient with a therapeutic agent that is targeted to the NRG1 fusion. Exemplary compositions for treating cancers containing the NRG1 fusion may comprise therapeutic agents inhibiting Epidermal Growth Factor Receptor and/or ERBB2 such as cetuximab, panitumumab, Sym004, MM-151, mAb 806, mAb 528, MEHD794A, gefitinib, erlotinib, lapatinib, afatinib, PD153035, AG1478, trastuzumab, and pertuzumab. In some embodiments, the therapeutic agent may be a combination of trastuzumab, and pertuzumab.