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    Modified release composition of at least one form of venlafaxine
    22.
    发明申请
    Modified release composition of at least one form of venlafaxine 审中-公开
    至少一种文拉法辛的释放组合物

    公开(公告)号：US20070098797A1

    公开(公告)日：2007-05-03

    申请号：US11445198

    申请日：2006-06-02

    Applicant: Fang Zhou ,  Werner Oberegger ,  Paul Maes

    Inventor： Fang Zhou ,  Werner Oberegger ,  Paul Maes

    IPC: A61K9/24

    CPC classification number: A61K9/2027 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/284 ,  A61K9/2866

    Abstract: The present invention relates to a modified release composition of at least one form of venlafaxine, which is a delayed controlled release composition. The composition comprises a core comprising at least one form of venlafaxine selected from the group consisting of venlafaxine, an active metabolite of venlafaxine, a pharmaceutically acceptable salt of venlafaxine, a pharmaceutically acceptable salt of an active metabolite of venlafaxine, and combinations thereof, less than 10% of a gelling agent and a pharmaceutically acceptable excipient. The composition further comprises a modified release coating which substantially surrounds the core which provides a delayed controlled release of the at least one form of venlafaxine.

    Abstract translation: 本发明涉及至少一种形式的文拉法辛的缓释组合物，其是延迟的控释组合物。 所述组合物包含至少一种文拉法辛的核心，其选自文拉法辛，文拉法辛的活性代谢物，文拉法辛的药学上可接受的盐，文拉法辛的活性代谢物的药学上可接受的盐及其组合，小于 10％胶凝剂和药学上可接受的赋形剂。 所述组合物还包含基本上围绕所述芯的改性释放包衣，其提供所述至少一种形式的文拉法辛的延迟控制释放。

    MODIFIED RELEASE FORMULATIONS OF AT LEAST ONE FORM OF TRAMADOL
    30.
    发明申请
    MODIFIED RELEASE FORMULATIONS OF AT LEAST ONE FORM OF TRAMADOL 有权
    至少一种TRAMADOL形式的修改释放配方

    公开(公告)号：US20080069888A1

    公开(公告)日：2008-03-20

    申请号：US11928908

    申请日：2007-10-30

    Applicant: Pawan SETH ,  Paul MAES

    Inventor： Pawan SETH ,  Paul MAES

    IPC: A61K31/135 ,  A61K9/14 ,  A61P29/00

    CPC classification number: A61K9/284 ,  A61K9/2866 ,  A61K31/137

    Abstract: The present invention relates to a modified release composition of at least one form of tramadol which is a delayed and extended release composition for oral administration suitable for once daily dosing. That composition comprises a core comprising at least one form of tramadol selected from the group consisting of tramadol, racemic mixtures thereof, enantiomers thereof, pharmaceutically acceptable salts thereof, and combinations thereof in combination with a pharmaceutically acceptable excipient. That composition further comprises a modified release coating which substantially surrounds said core. The compositions of the invention provide delayed and extended release of said at least one form of tramadol such that the mean plasma concentration of the at least one form of tramadol reaches a therapeutically effective level at a time which is after at least about 3 hours after first administration.

    Abstract translation: 本发明涉及至少一种形式的曲马多的改进释放组合物，其是适用于每日一次给药的口服给药的延迟释放组合物。 该组合物包含核心，其包含至少一种形式的曲马多，其选自曲马多，其外消旋混合物，其对映异构体，其药学上可接受的盐，及其组合与药学上可接受的赋形剂组合。 该组合物还包含基本上围绕所述芯的改性释放涂层。 本发明的组合物提供所述至少一种形式的曲马多的延迟和延长释放，使得至少一种形式的曲马多的平均血浆浓度在第一次至少约3小时后的时间达到治疗有效水平 行政。

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