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公开(公告)号：US20220163955A1
公开(公告)日：2022-05-26
申请号：US17437085
申请日：2020-03-18
申请人： Cytiva Sweden AB
IPC分类号： G05B23/02 , G05B19/418
摘要： The present disclosure relates to a method and system for monitoring a bio-pharmaceutical process, said bio-pharmaceutical process being controlled based on as set of instructions for controlling said biopharmaceutical process. The method comprises the following steps performed by a bio-pharmaceutical process monitoring element: obtaining (S11) said set of instructions for controlling the biopharmaceutical process, and while the instructions of the set of instructions for controlling the bio-pharmaceutical process are executed, for each executed instruction receiving (S13) an execution status update indicating which instruction is presently executed or has just been finished, and forming (S14) an execution status indication relating the instruction presently executed or just finished to its position in the set of instructions based on the received execution status update.
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公开(公告)号：US11321065B2
公开(公告)日：2022-05-03
申请号：US16486546
申请日：2018-02-22
申请人： Cytiva Sweden AB
发明人： Key Hyckenberg , Kjell Karlsson , Par Haggblad , Niklas Engblom
摘要： Disclosed is a method for automatic installation and setting up of an instrument (1), comprising the steps of: connecting (S1) the instrument (1) to a service software system (15) in a network (19) via a first communication interface (6); sending (S3) identification information (5) of the instrument (1) from the instrument to the service software system (15) via the first communication interface (6); recognizing (S5) in the service software system (15) at least one characteristic of the instrument (1) by analyzing the identification information (5); based on said at least one characteristic or identification information, creating (S7) by the service software system (15) dedicated high level control software (25) comprising parts of the control software needed for the instrument; based on said at least one characteristic or identification information, sending (S9) to the instrument (1) from the service software system (15) software to enable a second communication interface (16), and low level control software components needed for local control of the instrument, installing (S11) and configuring in the instrument the low level control software components received from the service software system; starting (S13) a built-in control software (9) in the instrument; using the (S15) the built-in control software in the instrument to access the high level control software dedicated for the instrument via the first, or a second communication interface (16), said built-in control software using the low level control software to monitor and control the instrument.
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公开(公告)号：US20220098538A1
公开(公告)日：2022-03-31
申请号：US17549636
申请日：2021-12-13
申请人： Cytiva Sweden AB
摘要： The present invention relates to a method and system for aseptic material transfer from a storage container to a biore-actor. More precisely the invention relates to a method and system for aseptically transferring dry material, such as microcarriers for cell cultivation, to a bioreactor, comprising transferring microcarriers from a first container housing said microcarriers to a bioreactor for cell cultivation via r transfer tubing connecting the first container to the bioreactor, wherein the transfer is accomplished with pressurized air or gas supplied to the container.
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公开(公告)号：US11225636B2
公开(公告)日：2022-01-18
申请号：US15573960
申请日：2016-05-16
申请人： Cytiva Sweden AB
摘要： The present invention relates to a method and system for aseptic material transfer from a storage container to a bioreactor. More precisely the invention relates to a method and system for aseptically transferring dry material, such as microcarriers for cell cultivation, to a bioreactor, comprising transferring microcarriers from a first container housing said microcarriers to a bioreactor for cell cultivation via r transfer tubing connecting the first container to the bioreactor, wherein the transfer is accomplished with pressurized air or gas supplied to the container.
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公开(公告)号：US20220010261A1
公开(公告)日：2022-01-13
申请号：US17294716
申请日：2019-12-03
申请人： Cytiva Sweden AB
发明人： Andreas Axén , Helena Ohrvik , Martin Antti
IPC分类号： C12M1/36 , C12M1/34 , G05B19/4155
摘要： The present invention relates to a computer implemented method (400) performed by a controller (C) configured to control a bioprocess comprised in a bioreactor (BR), the method comprising obtaining (410) measurement results by performing spectrophotometry of a bioprocessing fluid (FL), generating (420) control parameters based on the measurement results and one model and, controlling (430) the bioprocess using the generated parameters.
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公开(公告)号：US20210339209A1
公开(公告)日：2021-11-04
申请号：US17286834
申请日：2019-10-29
申请人： Cytiva Sweden AB
发明人： Mats Lundkvist
摘要： The present disclosure relates to a mixing device (9) comprising an inlet channel (25), an outlet channel (27), a mixing cavity (29) and a laminar mixing element (31) arranged within the mixing cavity. The inlet channel extends along an axis (21) of the mixing device from a first end (23) of the mixing device to the mixing cavity. The outlet channel extends along the axis from the mixing cavity to a second end (24) of the mixing device arranged opposite to the first end. The mixing cavity is arranged between the inlet channel and the outlet channel and extends in an axial direction (A) along the axis and in a radial direction (R) outwardly from the axis to an outer wall (30) of the mixing cavity. The laminar mixing element extends radially across the mixing cavity, subdividing the mixing cavity into an inlet portion (26) and an outlet portion (28). The mixing element comprises a plurality of holes (41) extending through the mixing element. The said holes are distributed over the mixing element.
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公开(公告)号：US20210260530A1
公开(公告)日：2021-08-26
申请号：US17252358
申请日：2019-06-20
申请人： Cytiva Sweden AB
发明人： Nityananda Maiya , Deepak Aravind , Fredrik Lundström , Saameera Simha Hindupur , Shivakumar Selvaraj , Alagur Sahebagouda
摘要： A method includes measuring, by a flow sensor (70), a flow rate of a permeate fluid (48) flowing through a filter (20) of a membrane filtration system (12). Further, the method includes receiving, by a control unit (86), the measured flow rate of the permeate fluid (48) and determining, by the control unit (86), a first flux rate of the filter (20) based on the measured flow rate of the permeate fluid (48). Furthermore, the method includes comparing, by the control unit (86), the determined first flux rate with a first predetermined flux rate. Additionally, the method includes operating the membrane filtration system (12), by the control unit (86), in a normal mode or a flux tolerant mode based on the comparison of the determined first flux rate with the first predetermined flux rate. The flux tolerant mode of the membrane filtration system (12) is further based on a determined normalized water permeability value of the filter (20).
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公开(公告)号：US11015160B2
公开(公告)日：2021-05-25
申请号：US15760022
申请日：2016-09-12
申请人： Cytiva Sweden AB
发明人： Eric Faldt , Ralph Stankowski
摘要： A filter holding device (1; 41; 75; 81) arranged for providing at least one filter (7; 43a, 43b; 85) inside a flexible bag (3; 71), said filter holding device comprising attaching means (19a-d, 21a-d; 79; 83) for attaching the filter holding device to an inner surface of the flexible bag such that the at least one filter held by the filter holding device is provided at a distance from the inner surface of the flexible bag.
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公开(公告)号：US20210146276A1
公开(公告)日：2021-05-20
申请号：US17156749
申请日：2021-01-25
申请人： Cytiva Sweden AB
摘要： A system for preparing solutions for chromatography application is disclosed. The system comprises a T-joint for preparing a buffer solution by mixing at least one first solution and a second solution. The T-joint receives the second solution from a solution supply unit connected to the T-joint. Further one or more low pressure pumps supply the one or more first solutions into the T-joint. The high pressure pump collects the buffer solution and delivers it to a chromatography apparatus.
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公开(公告)号：US11008542B2
公开(公告)日：2021-05-18
申请号：US15545378
申请日：2016-01-29
申请人： Cytiva Sweden AB
摘要： The invention discloses a first connection unit having a plurality of sensor surfaces and which is adapted to be aseptically connected to a second connection unit mounted e.g. on a flexible bioreactor bag.
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