公开(公告)号：US07510702B2

公开(公告)日：2009-03-31

申请号：US11501246

申请日：2006-08-07

Applicant: Joshua D Rabinowitz ,  Alejandro C Zaffaroni

Inventor： Joshua D Rabinowitz ,  Alejandro C Zaffaroni

IPC: A61K9/12 ,  A61K9/14 ,  A61M15/00

CPC classification number: A61K9/007 ,  A61K9/0073 ,  A61K9/12 ,  A61K31/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/27 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/473 ,  A61K31/485 ,  A61K31/49 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/5517 ,  A61K47/54 ,  A61M11/042 ,  A61M15/06 ,  A61M2205/8206 ,  F24V30/00 ,  Y10S514/923 ,  Y10S514/958

Abstract: The present invention relates to the delivery of nonsteroidal antiinflammatory drugs (NSAIDs) through an inhalation route. Specifically, it relates to aerosols containing NSAIDs that are used in inhalation therapy. In a method aspect of the present invention, an NSAID is delivered to a patient through an inhalation route. The method comprises: a) heating a coating of an NSAID, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particle having less than 5% NSAID degradation products. In a kit aspect of the present invention, a kit for delivering an NSAID through an inhalation route is provided which comprises: a) a coating of an NSAID composition and b) a device for dispensing said coating as a condensation aerosol.

Abstract translation: 本发明涉及通过吸入途径递送非甾体抗炎药（NSAID）。 具体地说，它涉及用于吸入治疗的含有NSAID的气溶胶。 在本发明的方法方面，通过吸入途径将NSAID递送给患者。 该方法包括：a）在固体支持物上加热NSAID的涂层以形成蒸汽; 并且b）使空气通过加热的蒸气以产生具有小于5％NSAID降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了用于通过吸入途径输送NSAID的试剂盒，其包括：a）NSAID组合物的涂层和b）用于将所述涂层分配为凝结气溶胶的装置。

公开(公告)号：US07465436B2

公开(公告)日：2008-12-16

申请号：US11442917

申请日：2006-05-30

Applicant: Joshua D Rabinowitz ,  Alejandro C Zaffaroni

Inventor： Joshua D Rabinowitz ,  Alejandro C Zaffaroni

IPC: A61K9/12 ,  A61K9/14 ,  A61M15/00

CPC classification number: A61K9/007 ,  A61K9/0073 ,  A61K9/12 ,  A61K31/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/27 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/473 ,  A61K31/485 ,  A61K31/49 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/5517 ,  A61K47/54 ,  A61M11/042 ,  A61M15/06 ,  A61M2205/8206 ,  F24V30/00 ,  Y10S514/923 ,  Y10S514/958

Abstract: The present invention relates to the delivery of antiparkinsons drugs through an inhalation route. In a method aspect of the present invention, an antiparkinsons drug is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of an antiparkinsons drug on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering an antiparkinsons drug through an inhalation route is provided which comprises: a) a thin coating of a an antiparkinsons drug composition; and, b) a device for dispending said thin coating as a condensation aerosol.

Abstract translation: 本发明涉及通过吸入途径递送抗帕金森药物。 在本发明的方法方面，通过吸入途径向患者施用抗帕金森药物。 该方法包括：a）在固体支持物上加热抗反注射药物的薄层以形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％药物降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了一种用于通过吸入途径递送反注射药物的试剂盒，其包括：a）抗反注射药物组合物的薄涂层; 和b）用于将所述薄涂层作为冷凝气溶胶进行排放的装置。

公开(公告)号：US07449172B2

公开(公告)日：2008-11-11

申请号：US11398383

申请日：2006-04-04

Applicant: Joshua D Rabinowitz ,  Alejandro C Zaffaroni

Inventor： Joshua D Rabinowitz ,  Alejandro C Zaffaroni

IPC: A61K9/12 ,  A61K9/14 ,  A61M15/00

CPC classification number: A61K9/007 ,  A61K9/0073 ,  A61K9/12 ,  A61K31/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/27 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/473 ,  A61K31/485 ,  A61K31/49 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/5517 ,  A61K47/54 ,  A61M11/042 ,  A61M15/06 ,  A61M2205/8206 ,  F24V30/00 ,  Y10S514/923 ,  Y10S514/958

Abstract: The present invention relates to the delivery of antiemetics through an inhalation route. Specifically, it relates to aerosols containing antiemetics that are used in inhalation therapy. In a method aspect of the present invention, an antiemetic is delivered to a patient through an inhalation route. The method comprises: a) heating a thin layer of an antiemetic, on a solid support, to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% antiemetic degradation products. In a kit aspect of the present invention, a kit for delivering an antiemetic through an inhalation route is provided which comprises: a) a thin layer of an antiemetic drug and b) a device for dispensing said thin layer an antiemetic as a condensation aerosol.

Abstract translation: 本发明涉及通过吸入途径递送止吐剂。 具体地说，它涉及用于吸入治疗的含有止吐剂的气溶胶。 在本发明的方法方面，止吐剂通过吸入途径递送给患者。 该方法包括：a）在固体支持物上加热止吐剂的薄层以形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％止吐降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了一种用于通过吸入途径递送止吐剂的试剂盒，其包括：a）止吐药物的薄层;以及b）用于将所述薄层分配为止吐剂作为凝结气雾剂的装置。

公开(公告)号：US20080045564A1

公开(公告)日：2008-02-21

申请号：US11620319

申请日：2007-01-05

Applicant: Richard Howard Roberts ,  Jie Du ,  Matthew William Davis ,  Kurt R. Nielsen

Inventor： Richard Howard Roberts ,  Jie Du ,  Matthew William Davis ,  Kurt R. Nielsen

IPC: A61K31/4745 ,  A61B5/00

CPC classification number: A61K31/49 ,  Y02A50/411 ,  A61K2300/00

Abstract: Disclosed herein is a method of using quinine. The method comprises informing a user that quinine does not induce the activity of a cytochrome p450 isozyme.

Abstract translation: 本文公开了使用奎宁的方法。 该方法包括通知使用者奎宁不诱导细胞色素p450同功酶的活性。

公开(公告)号：US20060251651A1

公开(公告)日：2006-11-09

申请号：US10538364

申请日：2003-12-12

Applicant: Shiro Shibayama ,  Kenji Sagawa ,  Noriki Watanabe ,  Kazuhiko Takeda ,  Hideaki Tada ,  Daikichi Fukushima

Inventor： Shiro Shibayama ,  Kenji Sagawa ,  Noriki Watanabe ,  Kazuhiko Takeda ,  Hideaki Tada ,  Daikichi Fukushima

IPC: A61K39/395 ,  G01N33/567 ,  C07K16/28

CPC classification number: A61K31/49 ,  A61K31/00 ,  A61K31/503 ,  A61K31/5377 ,  G01N2333/715 ,  G01N2500/04

Abstract: An antagonist or an agonist which binds to a strong binding site of CCR5; a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the same; a method for screening a compound which binds to a strong binding site of CCR5; a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the antagonist or the agonist selected by the screening method; an antagonist or an agonist which binds to a strong binding site of a chemokine receptor; a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the same; a method for screening a compound which binds to a strong binding site of a chemokine receptor; and a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer which comprises the antagonist or the agonist selected by the screening method. The antagonist or the agonist of the present invention is useful as a preventive and/or therapeutic agent for an allergic disease, an inflammatory disease, an immune disease and/or a cancer.

Abstract translation: 结合CCR5的强结合位点的拮抗剂或激动剂; 用于过敏性疾病，炎性疾病，免疫疾病和/或包含该疾病的癌症的预防和/或治疗剂; 用于筛选结合CCR5的强结合位点的化合物的方法; 包含通过筛选方法选择的拮抗剂或激动剂的过敏性疾病，炎性疾病，免疫疾病和/或癌症的预防和/或治疗剂; 结合趋化因子受体的强结合位点的拮抗剂或激动剂; 用于过敏性疾病，炎性疾病，免疫疾病和/或包含该疾病的癌症的预防和/或治疗剂; 用于筛选结合趋化因子受体的强结合位点的化合物的方法; 以及包含通过筛选方法选择的拮抗剂或激动剂的过敏性疾病，炎性疾病，免疫疾病和/或癌症的预防和/或治疗剂。 本发明的拮抗剂或激动剂可用作过敏性疾病，炎性疾病，免疫疾病和/或癌症的预防和/或治疗剂。

公开(公告)号：US20060251587A1

公开(公告)日：2006-11-09

申请号：US11479892

申请日：2006-06-30

Applicant: Joshua Rabinowitz ,  Alejandro Zaffaroni

Inventor： Joshua Rabinowitz ,  Alejandro Zaffaroni

IPC: A61K9/14 ,  A61L9/04

CPC classification number: A61K9/007 ,  A61K9/0073 ,  A61K9/12 ,  A61K31/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/27 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/473 ,  A61K31/485 ,  A61K31/49 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/5517 ,  A61K47/54 ,  A61M11/042 ,  A61M15/06 ,  A61M2205/8206 ,  F24V30/00 ,  Y10S514/923 ,  Y10S514/958

Abstract: The present invention relates to the delivery of analgesics through an inhalation route. Specifically, it relates to aerosols containing acetaminophen, orphenadrine or tramadol that are used in inhalation therapy. In a method aspect of the present invention, an analgesic is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of acetaminophen, orphenadrine or tramadol, on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% acetaminophen, orphenadrine or tramadol degradation products. In a kit aspect of the present invention, a kit for delivering acetaminophen, orphenadrine or tramadol through an inhalation is provided which comprises: a) a thin coating of an acetaminophen, orphenadrine or tramadol composition and b) a device for dispensing said thin coating as a condensation aerosol.

公开(公告)号：US20060246011A1

公开(公告)日：2006-11-02

申请号：US11479361

申请日：2006-06-30

Applicant: Joshua Rabinowitz ,  Alejandro Zaffaroni

Inventor： Joshua Rabinowitz ,  Alejandro Zaffaroni

IPC: A61K9/14 ,  A61L9/04

CPC classification number: A61K9/007 ,  A61K9/0073 ,  A61K9/12 ,  A61K31/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/27 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/473 ,  A61K31/485 ,  A61K31/49 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/5517 ,  A61K47/54 ,  A61M11/042 ,  A61M15/06 ,  A61M2205/8206 ,  F24V30/00 ,  Y10S514/923 ,  Y10S514/958

Abstract: The present invention relates to the delivery of diphenhydramine through an inhalation route. In a composition aspect of the present invention, a composition of a diphenhydramine condensation aerosol is presented. In a method aspect of the present invention, diphenhydramine aerosol is formed by: a) heating a thin layer of diphenhydramine on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% degradation product and an aerosol having an MMAD less than 3 microns. In a kit aspect of the present invention, a kit for delivering a condensation aerosol is provided which comprises: a) a thin coating of diphenhydramine; and b) a device for dispensing the diphenhydramine as an aerosol.

公开(公告)号：US20060233718A1

公开(公告)日：2006-10-19

申请号：US11451852

申请日：2006-06-13

Applicant: Joshua Rabinowitz ,  Alejandro Zaffaroni

Inventor： Joshua Rabinowitz ,  Alejandro Zaffaroni

IPC: A61K31/517 ,  A61K9/14 ,  A61L9/04

CPC classification number: A61K9/007 ,  A61K9/0073 ,  A61K9/12 ,  A61K31/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/165 ,  A61K31/192 ,  A61K31/216 ,  A61K31/27 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/473 ,  A61K31/49 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/517 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/5517 ,  A61K47/54 ,  F24V30/00 ,  Y10S514/958

Abstract: The present invention relates to aerosols containing alprazolam, estazolam, midazolam or triazolam that are used in inhalation therapy. In a method aspect of the present invention, alprazolam, estazolam, midazolam or triazolam is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of alprazolam, estazolam, midazolam or triazolam, on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering alprazolam, estazolam, midazolam or triazolam through an inhalation route is provided which comprises: a) a thin coating of an alprazolam, estazolam, midazolam, or triazolam composition and b) a device for dispensing said thin coating as a condensation aerosol.

Abstract translation: 本发明涉及用于吸入治疗的含有阿普唑仑，艾司唑仑，咪达唑仑或三唑仑的气溶胶。 在本发明的方法方面，通过吸入途径向患者施用阿普唑仑，艾司唑仑，咪达唑仑或三唑仑。 该方法包括：a）在固体支持物上加热阿普唑仑，艾司唑仑，咪达唑仑或三唑仑的薄层，形成蒸气; 和b）使空气通过加热的蒸气以产生具有小于5％药物降解产物的气溶胶颗粒。 在本发明的试剂盒方面，提供了一种用于通过吸入途径输送阿普唑仑，艾司唑仑，咪达唑仑或三唑仑的试剂盒，其包括：a）阿普唑仑，咪达唑仑或三唑仑组合物的薄涂层，和b） 用于分配所述薄涂层作为凝结气溶胶。

公开(公告)号：US07078020B2

公开(公告)日：2006-07-18

申请号：US10750303

申请日：2003-12-30

Applicant: Joshua D. Rabinowitz ,  Alejandro C. Zaffaroni

Inventor： Joshua D. Rabinowitz ,  Alejandro C. Zaffaroni

IPC: A61K9/12 ,  A61K9/14 ,  A61M15/00

CPC classification number: A61K9/007 ,  A61K9/0073 ,  A61K9/12 ,  A61K31/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/27 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/473 ,  A61K31/485 ,  A61K31/49 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/5517 ,  A61K47/54 ,  A61M11/042 ,  A61M15/06 ,  A61M2205/8206 ,  F24V30/00 ,  Y10S514/923 ,  Y10S514/958

Abstract: The present invention relates to the delivery of antipsychotics through an inhalation route. Specifically, it relates to aerosols containing antipsychotics that are used in inhalation therapy. In a method aspect of the present invention, an antipsychotic is delivered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises an antipsychotic, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% antipsychotic drug degradation products. In a kit aspect of the present invention, a kit for delivering an antipsychotic through an inhalation route is provided which comprises: a) a thin coating of an antipsychotic composition and b) a device for dispensing said thin coating as a condensation aerosol.

公开(公告)号：US07078018B2

公开(公告)日：2006-07-18

申请号：US10749539

申请日：2003-12-30

Applicant: Joshua D. Rabinowitz ,  Alejandro C. Zaffaroni

Inventor： Joshua D. Rabinowitz ,  Alejandro C. Zaffaroni

IPC: A61K9/12 ,  A61K9/14 ,  A61M15/00

CPC classification number: A61K9/007 ,  A61K9/0073 ,  A61K9/12 ,  A61K31/00 ,  A61K31/137 ,  A61K31/138 ,  A61K31/165 ,  A61K31/19 ,  A61K31/192 ,  A61K31/195 ,  A61K31/216 ,  A61K31/27 ,  A61K31/404 ,  A61K31/405 ,  A61K31/407 ,  A61K31/4196 ,  A61K31/421 ,  A61K31/422 ,  A61K31/423 ,  A61K31/437 ,  A61K31/473 ,  A61K31/485 ,  A61K31/49 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/5517 ,  A61K47/54 ,  A61M11/042 ,  A61M15/06 ,  A61M2205/8206 ,  F24V30/00 ,  Y10S514/923 ,  Y10S514/958

Abstract: The present invention relates to the delivery of opioids through an inhalation route. Specifically, it relates to aerosols containing opioids that are used in inhalation therapy. In a method aspect of the present invention, an opioid is delivered to a patient through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises an opioid, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles with less than 5% opioid degradation products. In a kit aspect of the present invention, a kit for delivering an opioid through an inhalation route is provided which comprises: a) a thin coating of an opioid composition and b) a device for dispensing said thin coating as a condensation aerosol.

Abstract translation: 本发明涉及通过吸入途径递送阿片样物质。 具体地说，它涉及用于吸入治疗的含有阿片样物质的气溶胶。 在本发明的方法方面，通过吸入途径将阿片样物质递送至患者。 该方法包括：a）加热组合物，其中组合物包含阿片样物质以形成蒸气; 和b）允许蒸气冷却，从而形成包含具有小于5％的阿片样降解产物的颗粒的冷凝气雾剂。 在本发明的试剂盒方面，提供了一种用于通过吸入途径递送阿片样物质的试剂盒，其包括：a）阿片剂组合物的薄涂层和b）用于分配所述薄涂层作为冷凝气溶胶的装置。