公开(公告)号：US3239508A

公开(公告)日：1966-03-08

申请号：US27704463

申请日：1963-04-30

Applicant: TOYO RAYON CO LTD

Inventor： YOSHIKAZU ITO ,  YOICHI SHIMOKAWA

IPC: C07D201/04 ,  C07D201/10

CPC classification number: C07D201/04 ,  C07D201/10

公开(公告)号：USRE25937E

公开(公告)日：1965-12-07

申请号：US25937D

IPC: C07D201/10

CPC classification number: C07D201/10

公开(公告)号：US09624242B2

公开(公告)日：2017-04-18

申请号：US14621726

申请日：2015-02-13

Applicant: CTI BIOPHARMA CORP.

Inventor： Brian Dymock ,  Cheng Hsia Angeline Lee ,  Anthony Deodaunia William

IPC: C07D498/08 ,  C07C55/22 ,  C07D201/10 ,  C07D498/04

CPC classification number: C07D498/08 ,  C07B2200/13 ,  C07C55/22 ,  C07D201/10 ,  C07D498/04

Abstract: The present invention relates to certain salts of a 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (Compound I) which have been found to have improved properties. In particular the present invention relates to the citrate salt of this compound. The invention also relates to pharmaceutical compositions containing the citrate salt and methods of use of the citrate salt in the treatment of certain medical conditions.

公开(公告)号：US4349473A

公开(公告)日：1982-09-14

申请号：US199218

申请日：1980-10-21

Applicant: Pier P. Rossi ,  Mario Catoni

Inventor： Pier P. Rossi ,  Mario Catoni

IPC: C07D201/16 ,  B01J19/18 ,  C07D201/08 ,  C07D201/10

CPC classification number: C07D201/10 ,  B01J19/1862 ,  C07D201/08 ,  B01J2219/00058 ,  B01J2219/00094 ,  B01J2219/00128

Abstract: Process for the preparation of .omega.-lactams (in particular caprolactam)ith improved yields, by reaction of cycloaliphatic derivatives having the general formula: ##STR1## wherein n=3-13 with nitrosating agents in the presence of dehydrating agents, characterized by the fact that the reaction is carried out a low temperature which is constant between stages, and in all the zones of a stage and with particular concentrations of the dehydrating agent.

Abstract translation: 通过在脱水剂存在下，通过使具有以下通式的脂环族衍生物（其中n = 3-13）与亚硝化剂反应制备具有改善产率的ω-内酰胺（特别是己内酰胺）的方法，其特征在于： 反应进行阶段之间恒定的低温，在一个阶段的所有区域和特定浓度的脱水剂中进行。

公开(公告)号：US3816404A

公开(公告)日：1974-06-11

申请号：US20619771

申请日：1971-12-08

Applicant: TEXACO INC

Inventor： KABLAOUI M ,  LOVE R ,  DURANLEAU R

IPC: C07C205/51 ,  C07D201/02 ,  C07D201/10 ,  C07D41/06

CPC classification number: C07D201/02 ,  C07C201/12 ,  C07C201/14 ,  C07D201/10 ,  Y02P20/582 ,  C07C205/45 ,  C07C205/51

Abstract: A METHOD FOR PREPARING CAPROLACTAM BY THE STEPS OF (1) NITRO-OXIDIZING CYCLOHEXENE TO 2-NITROCYCOLHEXANONE, (2) CLEAVING AND ESTERIFYING 2-NITROCYCLOHEXANONE WITH AN ALCOHOL TO FORM AN ALKYL 6-NITROHEXANOATE AND (3) CATALYTICALLY HYDROGENATING AND CYCLIZING THE NITROESTER TO CAPROLACTAM.

公开(公告)号：US3733317A

公开(公告)日：1973-05-15

申请号：US3733317D

申请日：1970-06-30

Applicant: SNIA VISCOSA

Inventor： GIUFFRE L ,  SIOLI G

IPC: C07D201/10 ,  C07D41/06

CPC classification number: C07D201/10

Abstract: THERE IS DESCRIBED A PROCESS FOR THE PREPARATION OF OMEGA-LACTAMS HAVING THE GENERAL FORMULA:

O=C
WHEREIN N= FROM 2 TO 13, AND/OR OF THEIR LACTAMIZABLE PRECURSORS, WHICH MAY BE CYCLOALIPHATIC OXIMES OR CYCLOALIPHATIC NITROSO DERIVATIVES, MONOMERS OR DIMERS CHARACTERIZED BY THE FACT THAT THE CORRESPONDING CYCLOMETHYLENE KETENE, HAVING THE GENERAL FORMULA

O=C=C
WHERE N HAS THE AFOREMENTIONED VALUE, IS SUBJECTED TO NITROSATION WITH A NITROSATING AGENT OF THE FORMULLA NOX, WHERE X CAN BE -HSOBJ4, -CL, -NO2, -OR (IN WHICH R INDICATES AN ALKYL OR ARYL ORGANIC SUBSTITUENT), AT A TEMPERATURE COMPRISED BETWEEN -60*C. AND + 100*C.

公开(公告)号：US3541080A

公开(公告)日：1970-11-17

申请号：US3541080D

申请日：1967-07-24

Applicant: TORAY INDUSTRIES

Inventor： WAKAMATSU SHIGERU ,  KONDO RYOZO ,  SHINOMIYA MASAYASU ,  OKAMOTO MASARU

IPC: B23K9/12 ,  C07D201/04 ,  C07D201/10 ,  C07D41/06

CPC classification number: C07D201/10 ,  B23K9/125 ,  C07D201/04

公开(公告)号：US3265685A

公开(公告)日：1966-08-09

申请号：US32128663

申请日：1963-11-04

Applicant: INVENTA AG

Inventor： HANS-JOACHIM SCHULTZE ,  JOHANN GIESEN ,  CLAU BERTHER

IPC: C07D201/10

CPC classification number: C07D201/10

公开(公告)号：US2719116A

公开(公告)日：1955-09-27

申请号：US41749054

申请日：1954-03-19

Applicant: OLIN MATHIESON

Inventor： BROWN BERNARD B

IPC: C07D201/10

CPC classification number: C07D201/10 ,  Y10S204/903 ,  Y10S204/912