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    NMR measurement method
    21.
    发明授权
    NMR measurement method 失效
    NMR测定法

    公开(公告)号：US07570053B2

    公开(公告)日：2009-08-04

    申请号：US12034445

    申请日：2008-02-20

    申请人： Kenichi Hasegawa ,  Kentarou Mizuno ,  Takahiro Anai

    发明人： Kenichi Hasegawa ,  Kentarou Mizuno ,  Takahiro Anai

    IPC分类号： G01V3/00

    CPC分类号： G01R33/31 ,  G01R33/34023 ,  G01R33/3403 ,  G01R33/34069 ,  G01R33/34076 ,  G01R33/34092 ,  G01R33/3635

    摘要： There is disclosed an NMR measurement method and NMR apparatus in which the temperature of the NMR detection coil or the RF irradiation coil hardly varies if pulsed RF power is applied to the coil during NMR measurements. The apparatus includes the detection coil or the RF irradiation coil, a first RF power application means for applying RF power of a frequency necessary for measurement of NMR signals, a second RF power application means for applying RF power of a frequency not affecting the measurement of NMR signals, and a control means for controlling the two power application means such that the sum of the RF power applied to the coil from the first application means and the RF power applied to the coil from the second application means is kept almost constant.

    摘要翻译： 公开了NMR测量方法和NMR装置，其中如果在NMR测量期间对线圈施加脉冲RF功率，则NMR检测线圈或RF照射线圈的温度几乎不变化。 该装置包括检测线圈或RF辐射线圈，用于施加测量NMR信号所需的频率的RF功率的第一RF功率施加装置，用于施加不影响测量的频率的RF功率的第二RF功率施加装置 NMR信号，以及用于控制两个功率施加装置的控制装置，使得施加到来自第一施加装置的线圈的RF功率和从第二施加装置施加到线圈的RF功率之和保持几乎恒定。

    Vacuum container for cooled magnetic resonance probe head
    22.
    发明授权
    Vacuum container for cooled magnetic resonance probe head 有权
    用于冷却磁共振探针头的真空容器

    公开(公告)号：US07514922B2

    公开(公告)日：2009-04-07

    申请号：US11898227

    申请日：2007-09-11

    申请人： Nicolas Freytag

    发明人： Nicolas Freytag

    IPC分类号： G01V3/00

    CPC分类号： G01R33/31 ,  G01R33/307 ,  G01R33/34023 ,  G01R33/3403 ,  G01R33/34061 ,  G01R33/34092 ,  G01R33/3415

    摘要： A magnetic resonance probe head (40) comprises a vacuum container (43) in which several RF resonator coils (31, 32; 51-54, 61-64) are disposed that can be cryogenically cooled and which are each designed as planar coils disposed parallel to a z direction. All of the RF resonator coils (31, 32; 51-54, 61-64) have a larger extension in an x direction (RSx) than in a y direction (RSy), wherein the x, y, z directions form a rectangular coordinate system. A central tube block (33; 81; 111; 121; 171; 181) is disposed between the RF resonator coils (31, 32; 51-54, 61-64) and has a recess (34, 112, 122) for a test sample (35), which is elongated in the z direction. The central tube block (33; 81; 111; 121; 171; 181) partially delimits the vacuum container and the recess (34, 112, 122) is disposed outside of the vacuum container (43). The central tube block (33; 81; 111; 121; 171; 181) has a larger extension in the x direction (ZRx) than in the y direction (ZRy) in the area between the RF resonator coils (31, 32; 51-54, 61-64). The inventive probe head improves the sensitivity, in particular, for small and round test samples.

    摘要翻译： 一个磁共振探针头（40）包括一个真空容器（43），其中设置有几个RF谐振器线圈（31,32; 51-54,61-64），可以被低温冷却，并且每个设计成平面线圈， 平行于az方向。 所有RF谐振器线圈（31,32; 51-54,61-64）在x方向（RSx）上具有比在ay方向（RSy）更大的延伸，其中x，y，z方向形成矩形坐标 系统。 中心管块（33; 81; 111; 121; 171; 181）设置在RF谐振器线圈（31,32; 51-54,61-64）之间，并具有凹部（34,112,122），用于 测试样品（35），其在z方向上是细长的。 中央管块（33; 81; 111; 121; 171; 181）部分地限定真空容器，并且凹部（34,112,122）设置在真空容器（43）的外部。 在RF谐振器线圈（31,32; 51）之间的区域中，中心管块（33; 81; 111; 121; 171; 181）在x方向（ZRx）上比在y方向（ZRy） -54,61-64）。 本发明的探头提高了灵敏度，特别是小和圆形的测试样品。

    Anticipative temperature regulation of cryogenic NMR probes
    24.
    发明申请
    Anticipative temperature regulation of cryogenic NMR probes 有权
    低温NMR探针的预期温度调节

    公开(公告)号：US20070096734A1

    公开(公告)日：2007-05-03

    申请号：US11260988

    申请日：2005-10-28

    申请人： Peter Lukens ,  Atholl Gibson

    发明人： Peter Lukens ,  Atholl Gibson

    IPC分类号： G01V3/00

    CPC分类号： G01R33/34 ,  G01R33/34023 ,  G01R33/3403 ,  G01R33/34092

    摘要： In some embodiments, a nuclear magnetic resonance (NMR) method comprises generating an indicator of an anticipated time-averaged power for a radio-frequency (RF) pulse set, and anticipatively adjusting a cooling supplied by a cryogenic cooling fluid to an RF coil according to the indicator of the anticipated time-averaged power. The cryogenic cooling adjustment may be performed using a cryogenic fluid heater and/or a mass flow controller disposed in the cryogenic fluid path. The time difference between the start of the cooling adjustment and the start of the RF pulse set is set to be equal to the difference in timescales between the cooling effect of the cooling adjustment and the heating effect of the RF pulse set on the RF coil.

    摘要翻译： 在一些实施例中，核磁共振（NMR）方法包括产生用于射频（RF）脉冲组的预期时间平均功率的指示符，并且预期地将由低温冷却流体供应的冷却调节到RF线圈，根据 到预期时间平均功率的指标。 低温冷却调节可以使用设置在低温流体路径中的低温流体加热器和/或质量流量控制器来执行。 将冷却调节开始与RF脉冲设定开始之间的时间差设定为等于冷却调节的冷却效果与设定在RF线圈上的RF脉冲的加热效果之间的时间标度差。

    NMR measurement method and NMR apparatus
    25.
    发明申请
    NMR measurement method and NMR apparatus 失效
    NMR测定法和NMR装置

    公开(公告)号：US20040251903A1

    公开(公告)日：2004-12-16

    申请号：US10821189

    申请日：2004-04-08

    申请人： JEOL Ltd.

    发明人： Kenichi Hasegawa ,  Kentarou Mizuno ,  Takahiro Anai

    IPC分类号： G01V003/00

    CPC分类号： G01R33/31 ,  G01R33/34023 ,  G01R33/3403 ,  G01R33/34069 ,  G01R33/34076 ,  G01R33/34092 ,  G01R33/3635

    摘要： There is disclosed an NMR measurement method and NMR apparatus in which the temperature of the NMR detection coil or the RF irradiation coil hardly varies if pulsed RF power is applied to the coil during NMR measurements. The apparatus includes the detection coil or the RF irradiation coil, a first RF power application means for applying RF power of a frequency necessary for measurement of NMR signals, a second RF power application means for applying RF power of a frequency not affecting the measurement of NMR signals, and a control means for controlling the two power application means such that the sum of the RF power applied to the coil from the first application means and the RF power applied to the coil from the second application means is kept almost constant.

    摘要翻译： 公开了NMR测量方法和NMR装置，其中如果在NMR测量期间对线圈施加脉冲RF功率，则NMR检测线圈或RF照射线圈的温度几乎不变化。 该装置包括检测线圈或RF辐射线圈，用于施加测量NMR信号所需的频率的RF功率的第一RF功率施加装置，用于施加不影响测量的频率的RF功率的第二RF功率施加装置 NMR信号，以及用于控制两个功率施加装置的控制装置，使得施加到来自第一施加装置的线圈的RF功率和从第二施加装置施加到线圈的RF功率之和保持几乎恒定。

    NMR measuring device having a cooled probe head
    27.
    发明授权
    NMR measuring device having a cooled probe head 失效
    NMR测量装置具有冷却的探针头

    公开(公告)号：US5889456A

    公开(公告)日：1999-03-30

    申请号：US49196

    申请日：1998-03-27

    申请人： Rene Triebe ,  Daniel Marek

    发明人： Rene Triebe ,  Daniel Marek

    IPC分类号： G01R33/32 ,  F25B9/10 ,  F25D19/00 ,  G01R33/34 ,  G01R33/36 ,  H01F5/00

    CPC分类号： G01R33/3403 ,  G01R33/34 ,  F25B9/10 ,  F25D19/006 ,  G01R33/34023 ,  Y10S505/892

    摘要： An NMR measuring device contains an NMR probe head (10a) having an NMR receiver coil (11), and the probe head can be supplied via a cryogenically insulated transfer conduit (9) with coolant from a cooling device (1a). The cooling device comprises a cryo-cooler (2) having a first cooling stage (4) with a first stage exchanger (12) and a second cooling stage (3) having a second stage exchanger (8). A pump (6) transports coolant in the cooling circuit. The NMR probe head (10a), in addition to the NMR receiver coils (11), has preamplifiers (21) for amplifying the received NMR signals and an additional cryogenically insulated transfer conduit (20) is inserted between the cooling device (1a) and the NMR probe head (10a) by means of which, the preamplifiers (21) and/or the components in contact with the preamplifiers (21) can be supplied with a flow of coolant at a higher temperature than that used for cooling the NMR receiver coils (11). Only the cryo-cooler (2) and, if appropriate, additional heat exchangers are required for cooling both coolant streams. In this fashion a substantial reduction in noise, including that of the amplifiers, is achieved using simple techniques and without great technical expense and difficulty.

    摘要翻译： NMR测量装置包含具有NMR接收器线圈（11）的NMR探针头（10a），并且探针头可以经由低温绝缘传输导管（9）与来自冷却装置（1a）的冷却剂供应。 冷却装置包括具有第一冷却级（4）和第一级交换器（12）的冷冻 - 冷却器（2）和具有第二级交换器（8）的第二冷却级（3）。 泵（6）在冷却回路中输送冷却剂。 除了NMR接收器线圈（11）之外，NMR探针头（10a）还具有放大接收的NMR信号的前置放大器（21），并且在冷却装置（1a）和 与前置放大器（21）接触的前置放大器（21）和/或与前置放大器（21）接触的部件的NMR探针头（10a）可以在比用于冷却NMR接收器的温度更高的温度下提供冷却剂流 线圈（11）。 只有冷冻机（2），如果合适，需要额外的热交换器来冷却两个冷却剂流。 以这种方式，包括放大器的噪声在内的显着降低是使用简单的技术实现的，并且没有很大的技术费用和困难。

    Apparatus for cooling NMR coils
    28.
    发明授权
    Apparatus for cooling NMR coils 失效
    用于冷却NMR线圈的设备

    公开(公告)号：US5508613A

    公开(公告)日：1996-04-16

    申请号：US297352

    申请日：1994-08-29

    申请人： Vincent Kotsubo ,  Robert D. Black

    发明人： Vincent Kotsubo ,  Robert D. Black

    IPC分类号： G01R33/34 ,  G01V3/00

    CPC分类号： F25D19/006 ,  G01R33/34 ,  G01R33/3403 ,  G01R33/34023

    摘要： In Nuclear Magnetic Resonance (NMR) spectroscopy and microscopy, noise from the receiver coil of the probe limits sensitivity. This noise may be reduced by cooling the receiver coil. Noise may be even further reduced by use of a superconducting receiver coil. However, high temperature superconductors must be maintained at temperatures significantly below the critical temperature, typically in the range of 10-60 K for proper performance. The invention provides an apparatus for cooling an NMR receiver coil to a desired temperature using a closed circuit refrigeration system. A cold fluid is circulated to a heat exchanger which is in thermal contact with a thermally conductive substrate having low magnetic susceptibility. The receiver coil is deposited on a portion of the substrate located distally from the heat exchanger. In the preferred embodiment, the substrate is sapphire and the receiver coil is a superconductive oxide. In one embodiment of the invention, the cold fluid is delivered through a cold-finger device, thus permitting easy access to the receiver coil while maintaining the closed circuit cooling.

    摘要翻译： 在核磁共振（NMR）光谱和显微镜中，来自探针的接收器线圈的噪声限制了灵敏度。 通过冷却接收器线圈可以降低噪声。 通过使用超导接收器线圈可以进一步降低噪声。 然而，高温超导体必须保持在明显低于临界温度的温度，通常在10-60 K的范围内，以获得适当的性能。 本发明提供一种使用闭路制冷系统将NMR接收器线圈冷却到所需温度的装置。 冷流体循环到与具有低磁化率的导热基板热接触的热交换器。 接收器线圈沉积在位于远离热交换器的衬底的一部分上。 在优选实施例中，衬底是蓝宝石，接收器线圈是超导氧化物。 在本发明的一个实施例中，冷流体通过冷指装置输送，从而允许容易地接近接收器线圈，同时保持闭路冷却。

    Method and means for the noninvasive, local, in-vivo examination of endogeneous tissue, organs, bones, nerves and circulating blood on account of spin-echo techniques
    29.
    发明授权
    Method and means for the noninvasive, local, in-vivo examination of endogeneous tissue, organs, bones, nerves and circulating blood on account of spin-echo techniques 失效
    由于自旋回波技术，对内源性组织，器官，骨骼，神经和循环血液进行无创，局部，体内检查的方法和手段

    公开(公告)号：US4442404A

    公开(公告)日：1984-04-10

    申请号：US326344

    申请日：1981-12-01

    申请人： Wilfried H. Bergmann

    发明人： Wilfried H. Bergmann

    IPC分类号： G01R33/28 ,  G01R33/34 ,  G01R33/36 ,  G01R33/38 ,  G01R33/3815 ,  G01R33/465 ,  G01R33/483 ,  G01R33/54 ,  G01R33/56 ,  G01R33/563 ,  G01N27/00

    CPC分类号： G01R33/326 ,  G01R33/28 ,  G01R33/3403 ,  G01R33/381 ,  G01R33/465 ,  G01R33/483 ,  G01R33/54 ,  G01R33/56 ,  G01R33/563 ,  G01R33/34023 ,  Y10S505/844

    摘要： This invention relates to methods and means for improving the sensitivity and signal-to-noise ratio of spin-echo measurements on samples, which have to remain at their own temperature and which have a non-negligible electrical conductivity. These are applied to noninvasive, localized, in vivo examinations of endogeneous tissue, organs, bones, nerves and circulating blood in the course of medical check-ups as well as for differential diagnostics and for the validation of therapeutic measures. This equipment comprises a system of magnets and an arrangement of transmitting and receiving coils encompassing the test person (patient) preferably completely, but at least the region of exploration. Means for the excitation as well as specialized low temperature equipment for the detection of NMR-signals emanating from a very small subregion are provided.

    摘要翻译： 本发明涉及用于提高自旋回波测量对样品的灵敏度和信噪比的方法和装置，其必须保持在其自身温度并且具有不可忽略的电导率。 这些应用于身体检查过程中内源性组织，器官，骨骼，神经和循环血液的非侵入性，局部化，体内检查，以及鉴别诊断和治疗措施的验证。 该设备包括磁体系统以及包括测试人员（患者）的线圈的发送和接收优选完全但至少是探索区域的布置。 提供用于激发的装置以及用于检测从非常小的子区域发出的NMR信号的专用低温设备。