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    BIOMAGNETIC RESONANCE DEVICE AND MEASURING METHOD THEREFOR
    3.
    发明申请
    BIOMAGNETIC RESONANCE DEVICE AND MEASURING METHOD THEREFOR 有权
    生物共振装置及其测量方法

    公开(公告)号：US20140343397A1

    公开(公告)日：2014-11-20

    申请号：US14446764

    申请日：2014-07-30

    申请人： Korea Research Institute of Standards and Science

    发明人： Kiwoong Kim ,  Yong-ho Lee ,  Seong-Joo Lee ,  Kwon-Kyu Yu

    IPC分类号： G01R33/385 ,  A61B5/055 ,  A61B5/05 ,  G01R33/48

    CPC分类号： G01R33/385 ,  A61B5/05 ,  A61B5/055 ,  G01R33/26 ,  G01R33/326 ,  G01R33/445 ,  G01R33/48 ,  G01R33/4806

    摘要： Provided are an ultra-low-field nuclear magnetic resonance device and an ultra-low-field nuclear magnetic resonance measuring method. The method includes applying a first measurement bias magnetic field corresponding to an excitation frequency of a coherent biomagnetic field generated in association with the electrophysiological activity of human body organs, applying a second measurement bias magnetic field having the same direction as the first measurement bias magnetic field and having a different magnitude than the first measurement bias magnetic field, and measuring a magnetic resonance signal generated in the human body by using magnetic field measuring means.

    摘要翻译： 提供了超低场核磁共振装置和超低场核磁共振测量方法。 该方法包括：对应于与人体器官的电生理活动相关联产生的相干生物磁场的激发频率对应的第一测量偏置磁场，施加与第一测量偏置磁场相同方向的第二测量偏置磁场 并且具有与第一测量偏置磁场不同的幅度，并且通过使用磁场测量装置来测量在人体中产生的磁共振信号。

    Low-noise cooling apparatus
    4.
    发明授权
    Low-noise cooling apparatus 有权
    低噪音冷却装置

    公开(公告)号：US08554294B2

    公开(公告)日：2013-10-08

    申请号：US13492496

    申请日：2012-06-08

    申请人： Ki-woong Kim ,  Chan Seok Kang ,  Seong-min Hwang ,  Seong-Joo Lee ,  Yong-Ho Lee

    发明人： Ki-woong Kim ,  Chan Seok Kang ,  Seong-min Hwang ,  Seong-Joo Lee ,  Yong-Ho Lee

    IPC分类号： G01R33/035

    CPC分类号： G01R33/445 ,  G01R33/326 ,  G01R33/3815

    摘要： A low-noise cooling apparatus is provided. The cooling apparatus includes an outer container and an inner container. A thermal insulation layer in a vacuum state is disposed between the outer container and the inner container. The inner container includes a Dewar containing a liquid refrigerant, a prepolarization coil arranged inside the inner container and immersed in the liquid refrigerant, a pick-up coil immersed in the liquid refrigerant, and a superconducting quantum interference device (SQUID) electrically connected to the pick-up coil and immersed in the liquid refrigerant. The prepolarization coil is made of a superconductor.

    摘要翻译： 提供了一种低噪声冷却装置。 冷却装置包括外容器和内容器。 在外部容器和内部容器之间设置真空状态的绝热层。 内部容器包括含有液体制冷剂的杜瓦瓶，布置在内部容器内部并浸没在液体制冷剂中的预极化线圈，浸没在液体制冷剂中的拾取线圈和与该制冷剂电连接的超导量子干涉装置（SQUID） 拾取线圈并浸没在液体制冷剂中。 预极化线圈由超导体制成。

    Squid detected NMR and MRI at ultralow fields
    6.
    发明授权
    Squid detected NMR and MRI at ultralow fields 失效
    鱿鱼在超低场检测到核磁共振和核磁共振

    公开(公告)号：US07466132B2

    公开(公告)日：2008-12-16

    申请号：US11740339

    申请日：2007-04-26

    申请人： John Clarke ,  Alexander Pines ,  Robert F. McDermott ,  Andreas H. Trabesinger

    发明人： John Clarke ,  Alexander Pines ,  Robert F. McDermott ,  Andreas H. Trabesinger

    IPC分类号： G01V3/00

    CPC分类号： G01R33/326 ,  G01R33/0356 ,  G01R33/445

    摘要： Nuclear magnetic resonance (NMR) signals are detected in microtesla fields. Prepolarization in millitesla fields is followed by detection with an untuned dc superconducting quantum interference device (SQUID) magnetometer. Because the sensitivity of the SQUID is frequency independent, both signal-to-noise ratio (SNR) and spectral resolution are enhanced by detecting the NMR signal in extremely low magnetic fields, where the NMR lines become very narrow even for grossly inhomogeneous measurement fields. MRI in ultralow magnetic field is based on the NMR at ultralow fields. Gradient magnetic fields are applied, and images are constructed from the detected NMR signals.

    摘要翻译： 核磁共振（NMR）信号在微量场中检测。 随后用毫米级直流超导量子干涉仪（SQUID）磁力计检测millitesla场的预偏振。 由于SQUID的灵敏度是频率无关的，所以通过检测极低磁场中的NMR信号来提高信噪比（SNR）和光谱分辨率，即使对于非常不均匀的测量场，NMR线也变得非常窄。 超低磁场中的MRI是基于超低场的NMR。 应用梯度磁场，并根据检测到的NMR信号构建图像。

    Squid detected NMR and MRI at ultralow fields
    7.
    发明授权
    Squid detected NMR and MRI at ultralow fields 有权
    鱿鱼在超低场检测到核磁共振和核磁共振

    公开(公告)号：US07218104B2

    公开(公告)日：2007-05-15

    申请号：US11534757

    申请日：2006-09-25

    申请人： John Clarke ,  Robert McDermott ,  Alexander Pines ,  Andreas Heinz Trabesinger

    发明人： John Clarke ,  Robert McDermott ,  Alexander Pines ,  Andreas Heinz Trabesinger

    IPC分类号： G01V3/00

    CPC分类号： G01R33/326 ,  G01R33/0356 ,  G01R33/445

    摘要： Nuclear magnetic resonance (NMR) signals are detected in microtesla fields. Prepolarization in millitesla fields is followed by detection with an untuned dc superconducting quantum interference device (SQUID) magnetometer. Because the sensitivity of the SQUID is frequency independent, both signal-to-noise ratio (SNR) and spectral resolution are enhanced by detecting the NMR signal in extremely low magnetic fields, where the NMR lines become very narrow even for grossly inhomogeneous measurement fields. MRI in ultralow magnetic field is based on the NMR at ultralow fields. Gradient magnetic fields are applied, and images are constructed from the detected NMR signals.

    摘要翻译： 核磁共振（NMR）信号在微量场中检测。 随后用毫米级直流超导量子干涉仪（SQUID）磁力计检测millitesla场的预偏振。 由于SQUID的灵敏度是频率无关的，所以通过检测极低磁场中的NMR信号来提高信噪比（SNR）和光谱分辨率，即使对于非常不均匀的测量场，NMR线也变得非常窄。 超低磁场中的MRI是基于超低场的NMR。 应用梯度磁场，并根据检测到的NMR信号构建图像。

    SQUID detected NMR and MRI at ultralow fields
    8.
    发明申请
    SQUID detected NMR and MRI at ultralow fields 有权
    SQUID在超低场检测到NMR和MRI

    公开(公告)号：US20040027125A1

    公开(公告)日：2004-02-12

    申请号：US10360823

    申请日：2003-02-06

    发明人： John Clarke ,  Robert McDermott ,  Alexander Pines ,  Andreas Heinz Trabesinger

    IPC分类号： G01V003/00 ,  A61B008/02 ,  A61B008/06 ,  A61B008/12 ,  A61B005/05

    CPC分类号： G01R33/326 ,  G01R33/0356 ,  G01R33/445

    摘要： Nuclear magnetic resonance (NMR) signals are detected in microtesla fields. Prepolarization in millitesla fields is followed by detection with an untuned de superconducting quantum interference device (SQUID) magnetometer. Because the sensitivity of the SQUID is frequency independent, both signal-to-noise ratio (SNR) and spectral resolution are enhanced by detecting the NMR signal in extremely low magnetic fields, where the NMR lines become very narrow even for grossly inhomogeneous measurement fields. MRI in ultralow magnetic field is based on the NMR at ultralow fields. Gradient magnetic fields are applied, and images are constructed from the detected NMR signals.

    摘要翻译： 核磁共振（NMR）信号在微量场中检测。 随后用毫米级超导量子干涉仪（SQUID）磁力计检测millitesla场的预极化。 由于SQUID的灵敏度是频率无关的，所以通过检测极低磁场中的NMR信号来提高信噪比（SNR）和光谱分辨率，即使对于非常不均匀的测量场，NMR线也变得非常窄。 超低磁场中的MRI是基于超低场的NMR。 应用梯度磁场，并根据检测到的NMR信号构建图像。

    NMR/MRI with hyperpolarized gas and high Tc SQUID
    9.
    发明授权
    NMR/MRI with hyperpolarized gas and high Tc SQUID 失效
    具有超极化气体和高Tc SQUID的NMR / MRI

    公开(公告)号：US06159444A

    公开(公告)日：2000-12-12

    申请号：US393406

    申请日：1999-09-10

    申请人： Klaus Schlenga ,  Ricardo E. de Souza ,  Annjoe Wong-Foy ,  John Clarke ,  Alexander Pines

    发明人： Klaus Schlenga ,  Ricardo E. de Souza ,  Annjoe Wong-Foy ,  John Clarke ,  Alexander Pines

    IPC分类号： G01R33/28 ,  G01R33/36 ,  A61B5/055

    CPC分类号： G01R33/326 ,  G01R33/281 ,  Y10T436/24

    摘要： A method and apparatus for the detection of nuclear magnetic resonance (NMR) signals and production of magnetic resonance imaging (MRI) from samples combines the use of hyperpolarized inert gases to enhance the NMR signals from target nuclei in a sample and a high critical temperature (Tc) superconducting quantum interference device (SQUID) to detect the NMR signals. The system operates in static magnetic fields of 3 mT or less (down to 0.1 mT), and at temperatures from liquid nitrogen (77K) to room temperature. Sample size is limited only by the size of the magnetic field coils and not by the detector. The detector is a high Tc SQUID magnetometer designed so that the SQUID detector can be very close to the sample, which can be at room temperature.

    摘要翻译： 用于检测核磁共振（NMR）信号和从样品产生磁共振成像（MRI）的方法和装置组合使用超极化惰性气体以增强样品中目标核和高临界温度的NMR信号（ Tc）超导量子干涉器件（SQUID）来检测NMR信号。 该系统在3mT以下（低至0.1mT）的静态磁场和在液氮（77K）至室温的温度下工作。 样品尺寸仅由磁场线圈的尺寸而不是由检测器限制。 检测器是一种高Tc SQUID磁力计，设计使得SQUID检测器可以非常接近样品，可以在室温下。