LIPID NANO PARTICLE COMPLEX COMPRISING APTIDE FUSED WITH CELL PENETRATING MATERIALS AND USE SAME

    公开(公告)号:US20200376138A1

    公开(公告)日:2020-12-03

    申请号:US16892172

    申请日:2020-06-03

    Abstract: The present invention relates to a lipid nanoparticle complex comprising an aptide fused with a cell penetrating material and a use thereof. Particularly, the lipid nanoparticle complex according to the present invention contains long-chain and short-chain phospholipids, and comprises an aptide fused with a cell-penetrating material. In particular, when the long-chain and short-chain phospholipids are included in a specific molar ratio, the lipid nanoparticle complex exhibits a discoid structure. In addition, when the lipid nanoparticle complex comprises the aptide for STAT protein as an aptide, it has superior cell or skin cell permeability, delivers the aptide to the dermal layer to show treatment effect on psoriasis without side effects, inhibits the expression of fibrosis-related genes increased by TGF-β, and attenuates symptoms of pulmonary fibrosis in in vivo model. Thus, the lipid nanoparticle complex according to the present invention can be effectively used as a carrier for various aptides.

    BIO-INSPIRED, HIGHLY STRETCHABLE AND CONDUCTIVE DRY ADHESIVE PATCH, METHOD OF MANUFACTURING THE SAME AND WEARABLE DEVICE INCLUDING THE SAME

    公开(公告)号:US20200337640A1

    公开(公告)日:2020-10-29

    申请号:US16486245

    申请日:2018-02-05

    Abstract: In a method of manufacturing a biomimetic highly stretchable conductive dry adhesive patch, a mold including a plurality of holes is provided by etching a semiconductor substrate including an insulation layer based on a footing effect. A conductive polymer composite is provided by dispersing mixed conductive fillers in a liquid elastomer. The mixed conductive fillers are formed by mixing one-dimensional conductive fillers and two-dimensional conductive fillers. The conductive polymer composite is applied on the mold such that the conductive polymer composite is injected into the plurality of holes. A conductive dry adhesive structure including a plurality of micropillars corresponding to the plurality of holes is obtained by performing a post-treatment on the conductive polymer composite applied on the mold and by removing the mold. Each of the plurality of micropillars includes a body portion and a tip portion. The tip portion has a spatula shape, is formed on the body portion, and has an area larger than that of the body portion in a plan view.

    Display apparatus using blind panel
    368.
    发明授权

    公开(公告)号:US10803814B2

    公开(公告)日:2020-10-13

    申请号:US15660416

    申请日:2017-07-26

    Abstract: A display apparatus may be provided that includes: a transparent display panel; a blind panel which is disposed adjacent to the transparent display panel and includes a plurality of cells that are individually drivable; and a controller which changes an operation mode through an on/off of the transparent display panel and a selective drive of a cell included in the blind panel. As a result, the display apparatus according to the embodiment of the present invention is a transparent display apparatus using the OLED. The display apparatus is able to operate without the external environmental constraints and to operate in various modes including the display function.

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