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421 条记录 (耗时 0.026 秒)

    5-(1-aminocyclohexyl)-2(1H)-pyridinone compounds which have pharmaceutical utility
    33.
    发明授权
    5-(1-aminocyclohexyl)-2(1H)-pyridinone compounds which have pharmaceutical utility 失效
    具有药用效用的5-（1-氨基环己基）-2（1H） - 吡啶酮化合物

    公开(公告)号：US4978663A

    公开(公告)日：1990-12-18

    申请号：US394448

    申请日：1989-08-16

    申请人： Richard C. Effland ,  David M. Fink

    发明人： Richard C. Effland ,  David M. Fink

    IPC分类号： A61K31/44 ,  A61K20060101 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/4427 ,  A61P25/04 ,  A61P25/28 ,  C07D211/00 ,  C07D211/86 ,  C07D213/64 ,  C07D213/89 ,  C07D401/08 ,  C07D401/12 ,  C07F7/10 ,  C07F7/18

    CPC分类号： C07D213/64

    摘要： There are described compounds of the formula ##STR1## where n is 1,2 or 3;R.sub.1 is hydrogen, formyl, loweralkylcarbonyl, arylloweralkylcarbonyl, loweralkyl, arylloweralkyl, ##STR2## R.sub.5 and R.sub.6 being independently loweralkyl or alternatively the group ##STR3## taken as a whole is ##STR4## R.sub.2 is hydrogen, loweralkyl, loweralkenyl, arylloweralkyl, --CH.sub.2 C.tbd.CH, R.sub.7 and R.sub.8 being independently loweralkyl or alternatively the group ##STR5## taken as a whole is ##STR6## R.sub.3 is hydrogen or loweralkyl; and R.sub.4 is hydrogen or loweralkyl;which compounds are useful as analgesic agents and also for treating various memory dysfunctions.

    摘要翻译： 描述式为“IMAGE”的化合物，其中n为1,2或3; R 1是氢，甲酰基，低级烷基羰基，芳基低级烷基羰基，低级烷基，芳基低级烷基，R 5和R 6独立地是低级烷基，或者作为整体取代的基团R 2是氢，低级烷基，低级烯基 ，芳基低级烷基，-CH 2 C 3 CH 3，R 3和R 8独立地是低级烷基或者作为整体取代的基团是R 3是氢或低级烷基; 和R4是氢或低级烷基; 哪些化合物可用作镇痛剂并且还用于治疗各种记忆功能障碍。

    Intermediates for the preparation of tetrahydroisoquino[2,1-c][1,3]benzodiazepines
    36.
    发明授权
    Intermediates for the preparation of tetrahydroisoquino[2,1-c][1,3]benzodiazepines 失效
    用于制备四氢异喹啉[2,1-c] [1,3]苯并二氮杂卓的中间体

    公开(公告)号：US4963685A

    公开(公告)日：1990-10-16

    申请号：US454490

    申请日：1989-12-21

    申请人： Lawrence L. Martin ,  Richard C. Allen

    发明人： Lawrence L. Martin ,  Richard C. Allen

    IPC分类号： C07D471/04

    CPC分类号： C07D471/04

    摘要： Novel Tetrahydroisoquino[2,1-c][1,3]benzodiazepines are disclosed having the formula ##STR1## where X and Y are each independently hydrogen, halogen, loweralkyl, loweralkoxy or --CF.sub.3, and R is hydrogen or loweralkyl, and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility in enhancing memory.

    摘要翻译： 公开了新的四氢异喹啉[2,1-c] [1,3]苯并二氮杂，其具有式“IMAGE”，其中X和Y各自独立地为氢，卤素，低级烷基，低级烷氧基或-CF 3，R为氢或低级烷基， 其药学上可接受的酸加成盐，以及适用的几何和光学异构体及其外消旋混合物。 本发明的化合物显示用于增强记忆力的效用。

    Process for preparing N-aminocarbarbamates related to physostigmine
    38.
    发明授权
    Process for preparing N-aminocarbarbamates related to physostigmine 失效
    制备与毒扁豆碱相关的N-氨基磷酸酯的方法

    公开(公告)号：US4937341A

    公开(公告)日：1990-06-26

    申请号：US440833

    申请日：1989-11-24

    申请人： Edward J. Glamkowski

    发明人： Edward J. Glamkowski

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： There are disclosed various derivatives of physostigmine and related compounds of the formula below, ##STR1## where X, R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification, which compounds are useful for alleviating various memory dysfunctions characterized by a cholinergic deficit such as Alzheimer's disease.

    摘要翻译： 公开了下列化学式的毒扁豆碱及其相关化合物的各种衍生物，其中X，R 1，R 2和R 3如本说明书中所定义，该化合物可用于缓解以胆碱能缺乏为特征的各种记忆功能障碍如阿尔茨海默病 疾病。