利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

121 条记录 (耗时 0.043 秒)

    Heteroaryl-8-azabicyclo[3,2,1]octanes as antipsychotic agents, 5-HT.sub.3 receptor antagonists and inhibitors of the reuptake of serotonin
    9.
    发明授权
    Heteroaryl-8-azabicyclo[3,2,1]octanes as antipsychotic agents, 5-HT.sub.3 receptor antagonists and inhibitors of the reuptake of serotonin 失效
    杂芳基-8-氮杂双环[3,2,1]辛烷作为抗精神病药，5-HT3受体拮抗剂和5-羟色胺再摄取抑制剂

    公开(公告)号：US5334599A

    公开(公告)日：1994-08-02

    申请号：US37134

    申请日：1993-03-25

    申请人： Edward J. Glamkowski ,  David M. Fink ,  Barbara E. Kurys ,  Yulin Chiang

    发明人： Edward J. Glamkowski ,  David M. Fink ,  Barbara E. Kurys ,  Yulin Chiang

    IPC分类号： C07D451/02 ,  C07D401/04 ,  A61K31/46 ,  C07D413/04 ,  C07D417/04

    CPC分类号： C07D451/02

    摘要： This invention relates to compounds of the formula ##STR1## where X is --O--, --S-- or --NH--;Y is hydrogen, halogen and loweralkoxy;p is 1 or 2;n is 2, 3 or 4;R is hydrogen, loweralkyl, loweralkoxy, hydroxy, halogen, amino, loweralkylamino, nitro, loweralkylthio, trifiuoromethoxy, cyano, trifiuoromethyl, ##STR2## R.sub.1 is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, carboxyl, loweralkylamino, nitro, loweralkylthio, cyano, and trifiuoromethyl;m is 1 or 2; a pharmaceutically acceptable acid addition salt thereof and, where applicable the geometric and optical isomers and racemic mixtures thereof.The compounds and compositions of this invention are useful as antipsychotic as 5-HT.sub.3 receptor antagonists and as inhibitors of the reuptake of serotonin.

    摘要翻译： 本发明涉及式（I）的化合物，其中X是-O - ， - S-或-NH-; Y是氢，卤素和低级烷氧基; p为1或2; n为2,3或4; R是氢，低级烷基，低级烷氧基，羟基，卤素，氨基，低级烷基氨基，硝基，低级烷硫基，三氟甲氧基，氰基，三氟甲基，R1是氢，低级烷基，低级烷氧基，卤素，羟基，羧基，低级烷基氨基，硝基，低级烷硫基，氰基 和三氟甲基; m为1或2; 其药学上可接受的酸加成盐，以及适用的几何和旋光异构体及其外消旋混合物。 本发明的化合物和组合物可用作5-HT 3受体拮抗剂的抗精神病药和5-羟色胺再摄取的抑制剂。