公开(公告)号：US08357777B2

公开(公告)日：2013-01-22

申请号：US13173692

申请日：2011-06-30

申请人： Mario R. Mautino ,  Nicholas N. Vahanian ,  Won-Bin Young ,  Gabriela Rossi ,  Charles J. Link ,  Firoz Jaipuri

发明人： Mario R. Mautino ,  Nicholas N. Vahanian ,  Won-Bin Young ,  Gabriela Rossi ,  Charles J. Link ,  Firoz Jaipuri

IPC分类号： A61K38/16

CPC分类号： C07H5/04 ,  A61K31/70 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/55511 ,  C07H15/00 ,  C07H15/04

摘要： The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. The present invention describes prophylactic or therapeutic cancer vaccines based on purified TAA proteins or TAA-derived synthetic peptides altered by chemical, enzymatic or chemo-enzymatic methods to introduce αGal epi topes or αGal glycomimetic epitopes, in order to allow for enhanced opsonization of the antigen by natural anti-αGal antibodies to stimulate TAA capture and presentation, thereby inducing a humoral and cellular immune response to the TAA expressed by a tumor. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.

摘要翻译： 本发明涉及用于引起肿瘤细胞选择性靶向和杀伤的方法和组合物。 本发明描述了基于纯化的TAA蛋白或TAA衍生的合成肽的预防或治疗性癌症疫苗，其通过化学，酶学或化学 - 酶学方法改变​​以引入αGal表位或αGal糖模拟表位，以便允许增强抗原的调理作用 通过天然抗αGal抗体刺激TAA捕获和呈递，从而诱导由肿瘤表达的TAA的体液和细胞免疫应答。 因此，动物的免疫系统被刺激以产生将攻击和杀死存在于动物中的肿瘤细胞的肿瘤特异性细胞毒性细胞和抗体。

公开(公告)号：US20120003251A1

公开(公告)日：2012-01-05

申请号：US13173692

申请日：2011-06-30

申请人： Mario R. MAUTINO ,  Nicholas N. Vahanian ,  Won-Bin Young ,  Gabriela Rossi ,  Charles J. Link ,  Firoz Jaipuri

发明人： Mario R. MAUTINO ,  Nicholas N. Vahanian ,  Won-Bin Young ,  Gabriela Rossi ,  Charles J. Link ,  Firoz Jaipuri

IPC分类号： A61K39/00 ,  A61P35/00

CPC分类号： C07H5/04 ,  A61K31/70 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/55511 ,  C07H15/00 ,  C07H15/04

摘要： The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. The present invention describes prophylactic or therapeutic cancer vaccines based on purified TAA proteins or TAA-derived synthetic peptides altered by chemical, enzymatic or chemo-enzymatic methods to introduce αGal epi topes or αGal glycomimetic epitopes, in order to allow for enhanced opsonization of the antigen by natural anti-αGal antibodies to stimulate TAA capture and presentation, thereby inducing a humoral and cellular immune response to the TAA expressed by a tumor. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.

摘要翻译： 本发明涉及用于引起肿瘤细胞选择性靶向和杀伤的方法和组合物。 本发明描述了基于纯化的TAA蛋白或TAA衍生的合成肽的预防或治疗性癌症疫苗，其通过化学，酶学或化学 - 酶学方法改变​​以引入αGal表位或αGal糖模拟表位，以便允许增强抗原的调理作用 通过天然抗αGal抗体刺激TAA捕获和呈递，从而诱导由肿瘤表达的TAA的体液和细胞免疫应答。 因此，动物的免疫系统被刺激以产生将攻击和杀死存在于动物中的肿瘤细胞的肿瘤特异性细胞毒性细胞和抗体。

公开(公告)号：US06897020B2

公开(公告)日：2005-05-24

申请号：US09811842

申请日：2001-03-19

申请人： Charles J. Link ,  Tatiana Seregina ,  Nicholas N. Vahanian ,  James N. Higginbotham ,  W. Jay Ramsey ,  Bradley J. Powers ,  Sachet A. Shukla ,  Won Bin Young

发明人： Charles J. Link ,  Tatiana Seregina ,  Nicholas N. Vahanian ,  James N. Higginbotham ,  W. Jay Ramsey ,  Bradley J. Powers ,  Sachet A. Shukla ,  Won Bin Young

IPC分类号： C12N15/10 ,  C12Q1/68

CPC分类号： C12N15/10 ,  C12N15/1034

摘要： The present invention relates generally to methods and compositions for the identification of differential protein expression patterns and concomitantly the active genetic regions that are directly or indirectly involved in different tissue types, disease states, or other cellular differences desirable for diagnosis or for targets for drug therapy.

摘要翻译： 本发明一般涉及用于鉴定差异蛋白表达模式的方法和组合物，并且伴随地直接或间接参与不同组织类型，疾病状态或诊断所需的其它细胞差异或药物治疗靶标的活性遗传区域 。