公开(公告)号：US20220071894A1

公开(公告)日：2022-03-10

申请号：US17194587

申请日：2021-03-08

申请人： Progenity, Inc.

发明人： Mitchell Lawrence Jones ,  Christopher Loren Wahl ,  Sharat Singh ,  Harry Stylli ,  Allison Luo

IPC分类号： A61K9/00 ,  A61K31/4425 ,  A61K31/495 ,  A61K39/395

摘要： This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor.

公开(公告)号：US11230731B2

公开(公告)日：2022-01-25

申请号：US16373568

申请日：2019-04-02

申请人： Progenity, Inc.

发明人： Matthew Sekedat ,  Jeffrey Buis ,  Ronald David Beaubien, Jr. ,  Sharat Singh ,  Jeff Perry

IPC分类号： C12Q1/68 ,  C12Q1/6834

摘要： Compositions and methods, systems, and kits for detecting and quantifying variations in numbers of molecules, particularly variations in gene dosage, e.g., due to gene duplication, or to variations from the normal euploid complement of chromosomes, e.g., trisomy of one or more chromosomes that are normally found in diploid pairs, without digital sequencing.

公开(公告)号：US11224364B2

公开(公告)日：2022-01-18

申请号：US15844427

申请日：2017-12-15

申请人： Progenity Inc.

发明人： Ryan Elliott Jones ,  Hamilton Roger Tang ,  Rachel Ellen Gerver ,  Mitchell Lawrence Jones

IPC分类号： A61B5/1455 ,  A61B5/1459 ,  A61B5/06 ,  A61B5/00 ,  A61B5/145 ,  A61B1/00 ,  A61B1/04 ,  A61B5/07 ,  A61M31/00 ,  A61B5/024 ,  A61B5/0531 ,  A61B5/11 ,  A61B34/20 ,  A61B10/00

摘要： An ingestible device is disclosed which can produce spectral data of one or more analytes, as well as associated methods for characterizing the gastrointestinal tract of a subject which contains such analytes. Related kits and systems are also disclosed.

公开(公告)号：US20210363233A1

公开(公告)日：2021-11-25

申请号：US17253802

申请日：2019-06-19

申请人： Progenity, Inc.

发明人： Mitchell Lawrence Jones ,  Sharat Singh ,  Christopher Loren Wahl ,  Harry Stylli ,  Kevin David Howe ,  Arana Perera

IPC分类号： C07K16/24 ,  A61K9/00 ,  A61P1/04 ,  A61K9/48

摘要： This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an IL-12/IL-23 inhibitor.

公开(公告)号：US20210293824A1

公开(公告)日：2021-09-23

申请号：US17234574

申请日：2021-04-19

申请人： PROGENITY, INC.

发明人： Matthew COOPER ,  Sharat SINGH ,  Karen A. F. COPELAND ,  Lyndal HESTERBERG ,  Amin R. MAZLOOM ,  Mohammad ABBASI ,  Richard Giulio DEL MASTRO

IPC分类号： G01N33/68 ,  G16B25/10 ,  A61K31/138 ,  A61K31/166 ,  A61K31/198 ,  A61K31/277 ,  A61K31/4168 ,  A61K31/4422 ,  A61K31/502 ,  A61K31/517 ,  A61K31/549 ,  G01N33/543

摘要： Disclosed herein are methods, kits, tests, and systems for detecting, predicting, monitoring, or ruling out preeclampsia in pregnant women. Also provided herein are novel diagnostic markers, methods of data analysis, assay formats, and kits employing such markers to improve one or more characteristics of a test for identifying or ruling out preeclampsia based on biomarkers from patient samples.

公开(公告)号：US20210121533A1

公开(公告)日：2021-04-29

申请号：US16497117

申请日：2018-03-30

申请人： Progenity, Inc.

发明人： Mitchell Lawrence Jones ,  Sharat Singh ,  Christopher Loren Wahl ,  Harry Stylli

IPC分类号： A61K38/20 ,  A61P1/04 ,  A61M31/00 ,  C07K14/54

摘要： This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with IL-10 or an IL-10 agonist.

公开(公告)号：US20210038872A1

公开(公告)日：2021-02-11

申请号：US17024176

申请日：2020-09-17

申请人： Progenity, Inc.

发明人： Jeffrey A. Shimizu ,  Mitchell Lawrence Jones ,  Mark Sasha Drlik ,  Iman Niknia ,  Nathan John Muller ,  Tuyen Nguyen ,  Christopher Loren Wahl ,  Edward Mudge ,  Nicholas Mark Salt ,  Nia Eleri Stevens ,  Stuart Robert Abercrombie ,  Christopher Ian Bunce ,  Nelson Quintana

IPC分类号： A61M31/00

摘要： An ingestible device, includes a storage reservoir configured to store a dispensable substance and a pressurized chamber configured so that, when a restraining force is removed from the pressurized chamber, the dispensable substance exits the ingestible device via openings in the ingestible device.

公开(公告)号：US20210031012A1

公开(公告)日：2021-02-04

申请号：US16964281

申请日：2019-01-24

申请人： Progenity, Inc.

发明人： Mitchell Lawrence Jones ,  Sharat Singh ,  Christopher Loren Wahl ,  Harry Stylli ,  Kevin David Howe ,  Aruna Perera

IPC分类号： A61M31/00 ,  A61P1/00 ,  A61K9/00 ,  A61K31/519

摘要： This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a PDE4 inhibitor.

公开(公告)号：US10465245B2

公开(公告)日：2019-11-05

申请号：US15224463

申请日：2016-07-29

申请人： Progenity, Inc.

发明人： Tobias Mann ,  Heng Wang ,  Jung H. Kim ,  Matthew Sekedat

IPC分类号： C12Q1/6883 ,  G16B25/00 ,  G16B30/00 ,  C12Q1/6811 ,  C12Q1/6827 ,  G16H50/20 ,  C12Q1/6816

摘要： Methods and nucleic acid molecules for detecting chromosomal abnormalities such as aneuploidy. Methods for selecting nucleic acid molecules for use in the methods of the disclosure.

公开(公告)号：US20230312700A1

公开(公告)日：2023-10-05

申请号：US17253811

申请日：2019-06-19

申请人： Progenity, Inc.

发明人： Mitchell Lawrence Jones ,  Sharat Singh ,  Christopher Loren Wahl ,  Harry Stylli ,  Kevin David Howe ,  Arana Perera

IPC分类号： C07K16/24 ,  A61K9/00 ,  A61K9/19 ,  A61P37/06

CPC分类号： C07K16/241 ,  A61K9/0004 ,  A61K9/19 ,  A61P37/06

摘要： This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a TNF-alpha inhibitor.