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    FUNCTIONAL LIGANDS TO THC
    33.
    发明申请
    FUNCTIONAL LIGANDS TO THC 审中-公开

    公开(公告)号：US20180066264A1

    公开(公告)日：2018-03-08

    申请号：US15811578

    申请日：2017-11-13

    Applicant: Base Pair Biotechnologies, Inc.

    Inventor： George W. Jackson

    IPC: C12N15/115 ,  C12N15/10

    CPC classification number: C12N15/115 ,  C12N15/1048 ,  C12N2310/16 ,  C12N2320/13

    Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as THC.

    FUNCTIONAL LIGANDS TO SARS-COV-2 SPIKE PROTEIN
    34.
    发明申请
    FUNCTIONAL LIGANDS TO SARS-COV-2 SPIKE PROTEIN 有权

    公开(公告)号：US20220396795A1

    公开(公告)日：2022-12-15

    申请号：US17772128

    申请日：2021-05-25

    Applicant: BASE PAIR BIOTECHNOLOGIES , INC.

    Inventor： GEORGE JACKSON ,  GARAM LEE ,  JASMINE KUAR ,  ALEXANDER CHIU ,  RAFAL DRABEK

    IPC: C12N15/115

    Abstract: The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to targets, such as viruses (e.g. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)), and/or antigens thereof (e.g. Spike protein and/or its subunits).

    METHODS AND MATERIALS FOR SENSITIVE DETECTION OF TARGET MOLECULES
    38.
    发明申请
    METHODS AND MATERIALS FOR SENSITIVE DETECTION OF TARGET MOLECULES 审中-公开

    公开(公告)号：US20180356408A1

    公开(公告)日：2018-12-13

    申请号：US15777329

    申请日：2016-11-19

    Applicant: Base Pair Biotechnologies, Inc. ,  University of Delaware

    Inventor： George W. Jackson ,  Jeffrey Caplan ,  Kun Huang ,  Blake Meyers

    IPC: G01N33/53 ,  C12N15/115

    CPC classification number: G01N33/5308 ,  C12N15/115 ,  C12N2310/16 ,  C12N2320/10

    Abstract: The subcellular localization of mRNA, and small RNA movement and trafficking of these molecules in an organism are important components of cellular and organismal regulation and communication. The next frontier for analysis of RNA will involve analysis at a single-molecule level, and at the subcellular level. This invention relates to methods and materials for sensitive detection of target molecules, particularly to methods and materials for binding or otherwise associating with target molecules and producing a signal for detection of, for example, spatial and/or temporal localization, and more particularly to methods and materials for the above using aptamers which bind to a chromophore or otherwise produce fluorescence or other detectable signal. This invention further relates to aptamers which bind to chromophores such as, for example, biliverdin or other related molecules, and also to such molecules which exhibit fluorescence or other detectable signals.

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