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公开(公告)号：US4202226A
公开(公告)日：1980-05-13
申请号：US875394
申请日：1978-02-06
申请人： Ronald K. Becker , Donald R. Korb
发明人： Ronald K. Becker , Donald R. Korb
CPC分类号： B24B13/046 , Y10T82/14 , Y10T82/148 , Y10T82/2543
摘要： The method of making plastic lenses ready for fitting to the contour of the wearer's eye comprising supporting a blank of plastic at one end for rotation about a predetermined axis, turning the blank down to a predetermined diameter, making an annular face cut at the distal end of the blank of predetermined radial width, making a spherically concave base cut at said distal end of predetermined depth relative to said annular face cut, reversing the blank end-for-end, making a first spherically convex cut at said end of the blank of a predetermined radius such that the distance between the inner and outer surfaces is of a predetermined thickness and making a flange cut at the marginal edge of the outer convex surface of lesser radius of curvature; and apparatus for carrying out the method.
摘要翻译： 制造适合佩戴者眼睛轮廓的塑料透镜的方法包括：在一端支撑塑料坯料以绕预定轴线旋转，将坯料向下转动到预定直径，从而在远端切割环形面 的预定径向宽度的坯料，在相对于所述环形面切割的预定深度的所述远端处切割球形凹形基底，使坯件端部端部反向，在坯料的所述端部处形成第一球形切口 使得内表面和外表面之间的距离为预定厚度并使凸缘在较小曲率半径的外凸表面的边缘处切割成预定半径; 以及用于执行该方法的装置。
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公开(公告)号：US4180308A
公开(公告)日：1979-12-25
申请号：US736555
申请日：1976-10-28
CPC分类号： G02C7/04 , A01N25/10 , A61K9/2027 , B01D71/40 , B29D11/00076 , C08F220/28 , G02B1/043
摘要： This invention concerns a minus prescription hydrogel contact lens that permits oxygen diffusion to the cornea in sufficient quantity to avoid the effects of oxygen deprivation; avoids the physiological complications arising from damage to the bulbar conjunctivia due to compression of the limbal capillaries; and avoids corneal scleral or wetting deficiencies. These advantages are accomplished through a combination of lens design and hydrogel properties.
摘要翻译： 本发明涉及一种减去处方水凝胶隐形眼镜，其允许足够量的氧气扩散到角膜以避免氧剥夺的影响; 避免由于角膜缘毛细血管的压迫引起的球结膜损伤引起的生理并发症; 并避免角膜巩膜或湿润不足。 这些优点通过透镜设计和水凝胶性质的组合来实现。
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公开(公告)号：US3957362A
公开(公告)日：1976-05-18
申请号：US451906
申请日：1974-03-18
IPC分类号： A01N25/10 , A61K9/20 , B01D71/40 , C08F220/28 , G02B1/04 , C08F220/14 , G02C7/04
CPC分类号： G02B1/043 , A01N25/10 , A61K9/2027 , B01D71/40 , C08F220/28
摘要： This invention relates to copolymers and hydrogels formed by copolymerization of a hydrophilic monomer from the group of dihydroxyalkyl acrylates and methacrylates and a substantially water insoluble monomer from the group of alkyl acrylates and methacrylates. The preferred copolymer of the invention is formed from methyl methacrylate and glyceryl methacrylate (2,3-dihydroxypropyl methacrylate). The hydrogels of the invention have unique physical and physiological properties which are particularly useful for the formation of contact lenses, particularly contact lenses having a relatively thin cross-section, though they may also be used for other purposes such as drug and pesticides delivery devices, dialysis, ultrafiltratiaon and reverse osmosis membranes, implants in surgery and dentistry and the like.
摘要翻译： 本发明涉及通过亲水性单体与丙烯酸酯和甲基丙烯酸二羟基烷基酯的共聚合而形成的共聚物和水凝胶以及丙烯酸烷基酯和甲基丙烯酸烷基酯基本上基本上不溶于水的单体。 本发明优选的共聚物由甲基丙烯酸甲酯和甲基丙烯酸甘油酯（甲基丙烯酸2,3-二羟基丙酯）形成。 本发明的水凝胶具有独特的物理和生理特性，其特别可用于形成隐形眼镜，特别是具有相对薄的横截面的隐形眼镜，尽管它们也可用于其它目的，例如药物和农药输送装置， 透析，超滤和反渗透膜，手术和牙科植入物等。
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公开(公告)号：US3545458A
公开(公告)日：1970-12-08
申请号：US3545458D
申请日：1968-09-30
申请人： DONALD R KORB , HAROLD R SHURTLEFF
发明人： KORB DONALD R , SHURTLEFF HAROLD R
CPC分类号： G02C13/008 , A45C11/005 , A61F9/0061 , Y10S134/901
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公开(公告)号：US09216028B2
公开(公告)日：2015-12-22
申请号：US13183901
申请日：2011-07-15
IPC分类号： A61F7/02 , A61H15/02 , A61B17/22 , A61F9/007 , A61H7/00 , A61B18/12 , A61B18/04 , A61F7/00 , A61H15/00 , A61N7/00
CPC分类号： A61B17/22004 , A61B18/12 , A61B2018/046 , A61B2018/048 , A61F7/02 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N7/00
摘要： In one embodiment, an apparatus for treating mammalian meibomian glands involves clearing the meibomian glands. The apparatus comprises a heater configured to apply a regulated heat to an eyelid containing the meibomian glands to a temperature adequate to melt obstructions in the meibomian glands to put the obstructions in a fluid or suspension (melted) state, and a controller maintaining the heat for a time period adequate to melt the obstructions. The glands can then be mechanically treated by a mechanical treatment applicator to express fluid from the glands by using a compressive force, wherein the treating is carried out either during the time period or after the time period but while the obstruction remains in a fluid state. Subsequent pharmacological treatment of the glands by use a pharmacological agent (topical or systemic) can then be used to assist in maintaining proper flow of lipids from the glands. This abstract is not to be considered limiting, since other embodiments may deviate from the features described in this abstract.
摘要翻译： 在一个实施方案中，用于治疗哺乳动物睑板腺的装置涉及清除睑板腺。 该装置包括加热器，该加热器构造成将包含睑板腺的眼睑施加调节的热量至足以熔化睑板腺中的阻塞物以将阻塞物置于流体或悬浮（熔化）状态的温度，以及控制器， 足以融化障碍物的时间段。 然后可以通过机械处理施加器机械地处理腺体，以通过使用压缩力来从腺体表达流体，其中处理在时间段期间或在时间段之后进行，但是在阻塞物保持在流体状态下。 然后通过使用药物（局部或全身）对腺体进行的后续药理学治疗可用于帮助保持来自腺体的适当的脂质流动。 该摘要不被认为是限制性的，因为其他实施例可能偏离本摘要中描述的特征。
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公开(公告)号：US09161905B2
公开(公告)日：2015-10-20
申请号：US11034527
申请日：2005-01-12
CPC分类号： A61K9/0048 , A61K9/107
摘要： This invention relates to an emulsion composition for the formation of an artificial tear film over the ocular surface of the eye capable of providing mechanical lubrication for the ocular surface while reducing evaporation of fluid therefrom. The emulsion is desirably in the form of a meta stable emulsion and is characterized by the use of a surfactant comprising a combination of a primary and secondary surfactant where the primary surfactant permits formation of the emulsion and the secondary surfactant permits autoclaving of the surfactant. The invention also includes a method for the formation of such an emulsion.
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公开(公告)号：US09044388B2
公开(公告)日：2015-06-02
申请号：US12290978
申请日：2008-11-05
CPC分类号： A61K9/0048 , A61K9/107
摘要： This invention relates to an emulsion composition for the formation of an artificial tear film over the ocular surface of the eye capable of providing mechanical lubrication for the ocular surface while reducing evaporation of fluid therefrom. The emulsion is desirably in the form of a meta stable emulsion and is characterized by the use of a surfactant comprising a combination of a primary and secondary surfactant where the primary surfactant permits formation of the emulsion and the secondary surfactant permits autoclaving of the surfactant. The invention also includes a method for the formation of such an emulsion.
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38.发明授权System for providing heat treatment and heat loss reduction for treating meibomian gland dysfunction 有权提供治疗睑板腺功能障碍的热处理和减少热量的系统公开(公告)号：US08632578B2
公开(公告)日：2014-01-21
申请号：US13368976
申请日：2012-02-08
IPC分类号： A61F7/00
CPC分类号： A61F7/12 , A61B18/12 , A61B2017/00084 , A61B2018/046 , A61B2018/048 , A61F7/007 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N7/00
摘要： A system for treating meibomian gland dysfunction comprising a heating element that applies heat to the tissue proximate the patient's meibomian glands to provide conductive heat transfer to the meibomian glands, which assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force application device may also apply force to tissue proximate the patient's meibomian glands during the application of heat to improve conductive heat transfer and reduce blood flow in tissue that causes convective heat loss, and to help express obstructions from the meibomian gland, including from a channel of the meibomian gland, with reduced discomfort to the patient. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands.
摘要翻译： 一种用于治疗睑板腺功能障碍的系统，其包括加热元件，所述加热元件对靠近患者睑板腺的组织施加热量，以向睑板腺提供导电热传递，这有助于在睑板腺中表达障碍物或闭塞以恢复足够的皮脂流 到脂质层治疗干眼症。 力施加装置还可以在施加热量的同时向附近的患者睑板腺的组织施加力，以改善导电热传递并减少导致对流热损失的组织中的血流，并且帮助表达来自睑板腺的阻塞物，包括来自 睑板腺的通道，对患者的不适感降低。 达到升高的温度水平可能会改善睑板腺的阻塞或闭塞的融化，松动或软化。
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公开(公告)号：US20120265101A1
公开(公告)日：2012-10-18
申请号：US13271768
申请日：2011-10-12
IPC分类号： A61B3/10
CPC分类号： A61B5/4261 , A61B3/10
摘要： Methods of diagnosing meibomian gland dysfunction are disclosed. The methods may be standardized and provide an accurate diagnosis of whether meibomian gland dysfunction exists. In one embodiment, a method is provided that utilizes an evaluation tool to apply a force for a preselected period of time to at least one of a plurality of meibomian glands in two or more regions of a plurality of regions of an eyelid. A grade is assigned to the at least one meibomian gland of the plurality of meibomian glands in each of the two or more regions based on any secretion that is expressed from each meibomian gland. In this manner, a plurality of meibomian gland secretion grades is obtained. The plurality of meibomian gland secretion grades is indicative of the presence of meibomian gland dysfunction.
摘要翻译： 公开了睑板腺功能障碍诊断方法。 方法可以被标准化，并提供是否存在睑板腺功能障碍的准确诊断。 在一个实施例中，提供了一种利用评估工具将预定时间段的力施加到眼睑多个区域的两个或更多个区域中的多个睑板腺中的至少一个的方法。 基于从每个睑板腺表达的任何分泌，将等级分配给两个或更多个区域中的每一个中的多个睑板腺中的至少一个睑板腺。 以这种方式，获得多个睑板腺分泌等级。 多个睑板腺分泌级别表示睑板腺功能障碍的存在。
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40.发明申请SYSTEM FOR PROVIDING HEAT TREATMENT AND HEAT LOSS REDUCTION FOR TREATING MEIBOMIAN GLAND DYSFUNCTION 有权用于治疗脑血管功能障碍的热处理和热量减少系统公开(公告)号：US20120143102A1
公开(公告)日：2012-06-07
申请号：US13368976
申请日：2012-02-08
CPC分类号： A61F7/12 , A61B18/12 , A61B2017/00084 , A61B2018/046 , A61B2018/048 , A61F7/007 , A61F9/00772 , A61F2007/0004 , A61F2007/0059 , A61H7/00 , A61H2015/0014 , A61N7/00
摘要： A system for treating meibomian gland dysfunction. A controller controls heat applied to the tissue proximate the patient's meibomian glands to provide conductive heat transfer to the meibomian glands. The application of heat assists in the expression of obstructions or occlusions in the meibomian glands to restore sufficient sebum flow to the lipid layer to treat dry eye. A force is also applied to tissue proximate the patient's meibomian glands during the application of heat to improve conductive heat transfer and reduce blood flow in tissue that causes convective heat loss. Thus, the application of force can further increase the temperature level and/or reduce the time to reach desired temperature levels for removing obstructions. Reaching increased temperature levels may improve the melting, loosening, or softening of obstructions or occlusions in the meibomian glands. Reducing the amount of time to reached desired temperature levels an aid in reducing discomfort to the patient during treatment.
摘要翻译： 治疗睑板腺功能障碍的系统。 控制器控制施加到患者睑板腺附近的组织的热量，以向睑板腺提供导电热传递。 热的应用有助于睑板腺中阻塞或闭塞的表达，以恢复足够的脂质流向脂质层以治疗干眼症。 在施加热量的同时，还将力施加到患者睑板腺附近的组织以改善导电传热并减少导致对流热损失的组织中的血流。 因此，施加力可以进一步增加温度水平和/或减少达到期望温度水平以消除障碍物的时间。 达到升高的温度水平可能会改善睑板腺的阻塞或闭塞的融化，松动或软化。 减少达到所需温度水平的时间量，有助于减轻治疗期间患者的不适。
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