公开(公告)号：US20080039611A1

公开(公告)日：2008-02-14

申请号：US11895553

申请日：2007-08-24

Applicant: Paul Fatheree ,  Martin Linsell ,  Daniel Long ,  Daniel Marquess ,  Edmund Moran ,  Matthew Nodwell ,  S. Derek Turner ,  James Aggen

Inventor： Paul Fatheree ,  Martin Linsell ,  Daniel Long ,  Daniel Marquess ,  Edmund Moran ,  Matthew Nodwell ,  S. Derek Turner ,  James Aggen

IPC: C07K9/00

CPC classification number: A61K31/545 ,  A61K38/00 ,  C07D277/40 ,  C07D277/42 ,  C07D407/12 ,  C07D407/14 ,  C07D501/00 ,  C07D501/46 ,  C07K9/008

Abstract: This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

公开(公告)号：US20070225329A1

公开(公告)日：2007-09-27

申请号：US11805101

申请日：2007-05-22

Applicant: Edmund Moran ,  John Jacobsen ,  Michael Leadbetter ,  Matthew Nodwell ,  Sean Trapp ,  James Aggen ,  Timothy Church

Inventor： Edmund Moran ,  John Jacobsen ,  Michael Leadbetter ,  Matthew Nodwell ,  Sean Trapp ,  James Aggen ,  Timothy Church

IPC: A61K31/47

CPC classification number: A61K31/4706 ,  A61K31/136 ,  A61K31/277 ,  A61K31/325 ,  A61K31/33 ,  A61K31/343 ,  A61K31/35 ,  A61K31/36 ,  A61K31/381 ,  A61K31/385 ,  A61K31/405 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/428 ,  A61K31/47 ,  A61K31/4704 ,  A61K31/4709 ,  A61K31/58 ,  C07C213/04 ,  C07C215/34 ,  C07C215/60 ,  C07C217/84 ,  C07C229/38 ,  C07C233/43 ,  C07C317/36 ,  C07D213/75 ,  C07D215/227 ,  C07D215/26 ,  C07D231/22 ,  C07D239/38 ,  C07D239/42 ,  C07D239/47 ,  C07D239/69 ,  C07D277/46 ,  C07D311/80 ,  C07D321/10 ,  C07D401/12 ,  C07D409/12 ,  C07D413/12 ,  A61K2300/00

Abstract: The invention provides novel β2 adrenergic receptor agonist compounds of formula (I): wherein R1-R13 and w have any of the values described in the specification. The invention also provides combinations of such compounds and other therapeutic agents, pharmaceutical compositions comprising such compounds and combinations, methods of using such compounds to treat diseases associated with β2 adrenergic receptor activity, and processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明提供新的β2肾上腺素能受体激动剂式（I）化合物：其中R 1 -R 13和w具有任何值 在说明书中描述。 本发明还提供了这些化合物和其它治疗剂的组合，包含这些化合物和组合的药物组合物，使用这些化合物治疗与β2肾上腺素能受体活性有关的疾病的方法，以及可用于 制备此类化合物。

公开(公告)号：US06974797B2

公开(公告)日：2005-12-13

申请号：US10269471

申请日：2002-10-11

Applicant: Paul R. Fatheree ,  Martin S. Linsell ,  Daniel D. Long ,  Daniel Marquess ,  Edmund J. Moran ,  Matthew B. Nodwell ,  S. Derek Turner ,  James Aggen

Inventor： Paul R. Fatheree ,  Martin S. Linsell ,  Daniel D. Long ,  Daniel Marquess ,  Edmund J. Moran ,  Matthew B. Nodwell ,  S. Derek Turner ,  James Aggen

IPC: C07D501/46 ,  A01N37/46 ,  A61K31/545 ,  A61K38/00 ,  A61K38/04 ,  A61P31/00 ,  A61P31/04 ,  C07D277/40 ,  C07D277/42 ,  C07D407/12 ,  C07D407/14 ,  C07D501/00 ,  C07D501/14 ,  C07D501/20 ,  C07K7/02 ,  C07K9/00

CPC classification number: A61K31/545 ,  A61K38/00 ,  C07D277/40 ,  C07D277/42 ,  C07D407/12 ,  C07D407/14 ,  C07D501/00 ,  C07D501/46 ,  C07K9/008

Abstract: This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明提供可用作抗生素的交联糖肽 - 头孢菌素化合物及其药学上可接受的盐。 本发明还提供含有这些化合物的药物组合物; 使用这些化合物治疗哺乳动物细菌感染的方法; 以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20050239691A1

公开(公告)日：2005-10-27

申请号：US11172303

申请日：2005-06-30

Applicant: Paul Fatheree ,  Martin Linsell ,  Daniel Long ,  Daniel Marquess ,  Edmund Moran ,  Matthew Nodwell ,  S. Turner ,  James Aggen

Inventor： Paul Fatheree ,  Martin Linsell ,  Daniel Long ,  Daniel Marquess ,  Edmund Moran ,  Matthew Nodwell ,  S. Turner ,  James Aggen

IPC: C07D501/46 ,  A01N37/46 ,  A61K31/545 ,  A61K38/00 ,  A61K38/04 ,  A61P31/00 ,  A61P31/04 ,  C07D277/40 ,  C07D277/42 ,  C07D407/12 ,  C07D407/14 ,  C07D501/00 ,  C07D501/14 ,  C07D501/20 ,  C07K7/02 ,  C07K9/00 ,  A61K38/14

CPC classification number: A61K31/545 ,  A61K38/00 ,  C07D277/40 ,  C07D277/42 ,  C07D407/12 ,  C07D407/14 ,  C07D501/00 ,  C07D501/46 ,  C07K9/008

Abstract: This invention provides cross-linked glycopeptide-cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

Abstract translation: 本发明提供可用作抗生素的交联糖肽 - 头孢菌素化合物及其药学上可接受的盐。 本发明还提供含有这些化合物的药物组合物; 使用这些化合物治疗哺乳动物细菌感染的方法; 以及可用于制备这些化合物的方法和中间体。

公开(公告)号：US20050026818A1

公开(公告)日：2005-02-03

申请号：US10888849

申请日：2004-07-09

Applicant: Paul Fatheree ,  Martin Linsell ,  Daniel Marquess ,  Sean Trapp ,  Edmund Moran ,  James Aggen

Inventor： Paul Fatheree ,  Martin Linsell ,  Daniel Marquess ,  Sean Trapp ,  Edmund Moran ,  James Aggen

IPC: A61K38/14 ,  A61P31/04 ,  C07D501/00 ,  C07K7/64 ,  C07K9/00

CPC classification number: C07K7/64 ,  C07D501/00 ,  C07K9/008

Abstract: This invention provides cross-linked glycopeptide—cephalosporin compounds and pharmaceutically acceptable salts thereof which are useful as antibiotics. This invention also provides pharmaceutical compositions containing such compounds; methods for treating bacterial infections in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

公开(公告)号：US06693202B1

公开(公告)日：2004-02-17

申请号：US09645609

申请日：2000-08-25

Applicant: James Aggen ,  John H. Griffin ,  Mathai Mammen ,  Daniel Marquess ,  Edmund J. Moran ,  David Oare

Inventor： James Aggen ,  John H. Griffin ,  Mathai Mammen ,  Daniel Marquess ,  Edmund J. Moran ,  David Oare

IPC: C07D20700

CPC classification number: A61K31/40 ,  C07C211/32 ,  C07C2603/32 ,  C07D207/08 ,  C07D209/48 ,  C07D211/46 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D417/12 ,  C07D519/00 ,  G01N33/566

Abstract: Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an allosteric modulator provided that at least one of said ligand is a muscarinic receptor antagonist. The multibinding compounds of this invention are useful in the treatment and prevention of diseases such as chronic obstructive pulmonary disease, chronic bronchitis, irritable bowel syndrome, urinary incontinence, and the like.

Abstract translation: 公开了作为毒蕈碱受体拮抗剂的多重联结化合物。 含有2-10个配体的本发明的多相结合化合物共价连接到一个或多个接头上。 每个配体彼此独立地是毒蕈碱受体拮抗剂或变构调节剂，只要至少一种所述配体是毒蕈碱受体拮抗剂即可。 本发明的多重联结化合物可用于治疗和预防慢性阻塞性肺疾病，慢性支气管炎，肠易激综合征，尿失禁等疾病。