公开(公告)号：US09158214B2

公开(公告)日：2015-10-13

申请号：US14127672

申请日：2012-05-30

Applicant: Kimihiro Yoshimura ,  Yohei Miyauchi ,  Keiko Yamagishi ,  Kazuhisa Shirayama ,  Maho Hori

Inventor： Kimihiro Yoshimura ,  Yohei Miyauchi ,  Keiko Yamagishi ,  Kazuhisa Shirayama ,  Maho Hori

IPC: G03G5/00 ,  G03G7/00 ,  G03G5/147 ,  G03G15/16

CPC classification number: G03G7/0053 ,  G03G5/14704 ,  G03G5/14734 ,  G03G5/14773 ,  G03G5/14795 ,  G03G15/162 ,  G03G2215/00957

Abstract: There are provided an electrophotographic photosensitive member and an intermediate transfer member each having good lubricity and good cleaning property on its surface, a process cartridge and an electrophotographic apparatus each including the electrophotographic photosensitive member, and an electrophotographic apparatus including the intermediate transfer member. Therefore, a surface layer of the electrophotographic photosensitive member or intermediate transfer member of the present invention contains a matrix component and a rotatably-retained spherical particle that is not bound with the matrix component and is rotatably retained in a pore in the matrix component.

Abstract translation: 提供了一种电子照相感光构件和中间转印构件，其各自在其表面上具有良好的润滑性和良好的清洁性，每个包括电子照相感光构件的处理盒和电子照相设备以及包括中间转印构件的电子照相设备。 因此，本发明的电子照相感光体或中间转印体的表面层含有不与基体成分结合的基体成分和可旋转保持的球状粒子，并可旋转地保持在基体成分的孔中。

公开(公告)号：US08093060B2

公开(公告)日：2012-01-10

申请号：US12393011

申请日：2009-02-25

Applicant: Itaru Hamachi ,  Fumio Yamauchi ,  Tetsuya Yano ,  Kimihiro Yoshimura ,  Akio Ojida ,  Takashi Sakamoto ,  Masaaki Inoue

Inventor： Itaru Hamachi ,  Fumio Yamauchi ,  Tetsuya Yano ,  Kimihiro Yoshimura ,  Akio Ojida ,  Takashi Sakamoto ,  Masaaki Inoue

IPC: G01N33/48

CPC classification number: C07F5/022 ,  C07D207/335 ,  C07D401/14 ,  G01N33/6842 ,  Y10T436/16 ,  Y10T436/163333

Abstract: A compound which captures a multisite phosphorylated peptide or protein specifically to a phosphorylation site and a method for detecting the peptide or protein using the compound. Particularly, a compound which specifically detects an excessively phosphorylated tau protein observed in the brain affected by Alzheimer's disease and a method for diagnosing Alzheimer's disease in vitro or in vivo using the compound are provided. By bringing a metal complex compound having two dipicolylamine (Dpa) moieties and a spacer including a chromogenic or luminescent functional or atom group into contact with a multisite phosphorylated peptide or protein, the compound recognizes the distance between phosphate groups and specifically binds to the peptide or protein, and a multisite phosphorylated peptide or protein or kinase activity is optically detected by measuring the change, or a multisite phosphorylated peptide or protein or kinase activity is imaged by an optical imaging method applying the change in luminescence.

Abstract translation: 捕获特异性磷酸化位点的多位点磷酸化肽或蛋白质的化合物和使用该化合物检测肽或蛋白质的方法。 特别地，提供了特异性检测在受阿尔茨海默氏病影响的脑中观察到的过度磷酸化的tau蛋白的化合物以及使用该化合物在体外或体内诊断阿尔茨海默病的方法。 通过使具有两个二苯基胺（Dpa）部分的金属络合物和包含显色或发光官能团或原子基团的间隔基与多位点磷酸化肽或蛋白质接触，化合物识别磷酸基团之间的距离，并特异性结合肽或 蛋白质和多位点磷酸化肽或蛋白质或激酶活性通过测量变化来光学检测，或者通过应用发光变化的光学成像方法对多位点磷酸化肽或蛋白质或激酶活性进行成像。

公开(公告)号：US20100326956A1

公开(公告)日：2010-12-30

申请号：US12877158

申请日：2010-09-08

Applicant: Hirokatsu Miyata ,  Kazuhiro Yamauchi ,  Kimihiro Yoshimura

Inventor： Hirokatsu Miyata ,  Kazuhiro Yamauchi ,  Kimihiro Yoshimura

IPC: B05D3/10 ,  B05D3/00

CPC classification number: H01J49/0418

Abstract: A substrate for mass spectrometry for effectively performing ionization has been demanded. The substrate for mass spectrometry includes a base, a porous film formed on the base, and an inorganic material film formed on the porous film. The inorganic material film has a plurality of concaves formed vertically to the base, and the diameter of the concaves is not less than 1 nm and less than 1 μm.

Abstract translation: 已经要求用于有效地进行电离的质谱用基板。 用于质谱的基板包括基底，形成在基底上的多孔膜和形成在多孔膜上的无机材料膜。 无机材料膜具有与基底垂直形成的多个凹部，凹部的直径为1nm以上且1μm以下。

公开(公告)号：US20100247444A1

公开(公告)日：2010-09-30

申请号：US12675581

申请日：2008-09-08

Applicant: Kimihiro Yoshimura ,  Fumio Yamauchi ,  Katsuaki Kuge ,  Tetsuya Yano ,  Masahiro Shirakawa ,  Yasuhiro Aoyama

Inventor： Kimihiro Yoshimura ,  Fumio Yamauchi ,  Katsuaki Kuge ,  Tetsuya Yano ,  Masahiro Shirakawa ,  Yasuhiro Aoyama

IPC: A61K49/10 ,  C07F9/02 ,  A61P43/00

CPC classification number: C07C215/40 ,  A61K49/10 ,  C07B2200/05 ,  C07C219/06 ,  C07F9/091 ,  C07F9/106 ,  G01N24/08 ,  G01R33/4608 ,  G01R33/5601 ,  G01R33/5605

Abstract: To produce a labeled compound for a selected biological substance not using a radioisotope atom which has a risk of exposure to radioactivity and limitation on handling time but using a stable isotope atom; and that the labeled compound can be measured with good sensitivity separably from naturally occurring compounds of the selected biological substance which are substituted with the stable isotope atom. Choline as a biological substance is labeled by substituting the nitrogen atom of the quaternary ammonium group and all the carbon atoms of the methyl group attached to the nitrogen atom with respective isotopes 15N and 13C and used as a diagnostic agent.

Abstract translation: 为了生产不使用具有暴露于放射性和限制处理时间但使用稳定同位素原子的放射性同位素原子的选定生物物质的标记化合物; 并且可以以与稳定同位素原子取代的所选择的生物物质的天然存在的化合物分离地具有良好的灵敏度来测量标记的化合物。 胆碱作为生物物质通过用各自的同位素15N和13C替代季铵基团的氮原子和与氮原子连接的甲基的所有碳原子并用作诊断剂进行标记。

公开(公告)号：US07695880B2

公开(公告)日：2010-04-13

申请号：US11754659

申请日：2007-05-29

Applicant: Kimihiro Yoshimura

Inventor： Kimihiro Yoshimura

IPC: G03G9/08

CPC classification number: G03G9/09716 ,  G03G9/09708 ,  G03G9/09725

Abstract: A toner, and an electrophotographic apparatus and an electrophotographic process cartridge using the toner are provided having excellent charge stability without adversely affecting electric properties of the toner even when used for a long period of time and having excellent image density stability without bringing about image deletion and blurring. The toner includes colored particles containing at least a binder resin and a colorant, and two or more external additives. At least one of the external additives includes hydrophobic treated mesoporous particles, and the mesoporous particles are inorganic particles of at least one type selected from the group consisting of silica, titanium oxide, alumina, cerium oxide, and strontium titanate.

Abstract translation: 提供使用调色剂的调色剂和电子照相设备以及使用调色剂的电子照相处理盒，其具有优异的电荷稳定性，而不会不利地影响调色剂的电性能，即使长时间使用并且具有优异的图像密度稳定性而不引起图像缺失， 模糊。 调色剂包括至少含有粘合剂树脂和着色剂的着色颗粒，以及两种或更多种外部添加剂。 至少一种外部添加剂包括疏水处理的介孔颗粒，并且介孔颗粒是选自二氧化硅，氧化钛，氧化铝，氧化铈和钛酸锶中的至少一种的无机颗粒。

公开(公告)号：US07364824B2

公开(公告)日：2008-04-29

申请号：US11617347

申请日：2006-12-28

Applicant: Toshihiro Kikuchi ,  Atsushi Ochi ,  Harumi Sako ,  Kimihiro Yoshimura ,  Hideaki Tamai ,  Nobuo Kosaka

Inventor： Toshihiro Kikuchi ,  Atsushi Ochi ,  Harumi Sako ,  Kimihiro Yoshimura ,  Hideaki Tamai ,  Nobuo Kosaka

IPC: G03G15/02

CPC classification number: G03G5/14786 ,  G03G5/0614 ,  G03G5/071 ,  G03G5/14717

Abstract: An electrophotographic photosensitive member, a process cartridge and an electrophotographic apparatus are provided which not only secure mechanical strength sufficiently but also bring a vast improvement in charge transport performance and which can well satisfy electrical properties. An electrophotographic photosensitive member is provided an outermost surface layer of which contains at least a charge transporting compound having chain polymerizable functional groups which is represented by the following general formula (1-1) or (1-2); the charge transporting compound having been polymerized or cross-linked and cured. Also provided are a process cartridge and an electrophotographic apparatus which have such a photosensitive member.

Abstract translation: 提供了一种电子照相感光构件，处理盒和电子照相设备，其不仅充分确保机械强度，而且还可以极大地改善电荷传输性能，并且可以很好地满足电性能。 提供电子照相感光构件，其最外表面层至少包含由以下通式（1-1）或（1-2）表示的具有链可聚合官能团的电荷输送化合物; 电荷输送化合物已经聚合或交联并固化。 还提供了具有这种感光构件的处理盒和电子照相设备。

公开(公告)号：US20070281232A1

公开(公告)日：2007-12-06

申请号：US11754659

申请日：2007-05-29

Applicant: Kimihiro Yoshimura

Inventor： Kimihiro Yoshimura

IPC: G03G9/08

CPC classification number: G03G9/09716 ,  G03G9/09708 ,  G03G9/09725

Abstract: A toner, and an electrophotographic apparatus and an electrophotographic process cartridge using the toner are provided having excellent charge stability without adversely affecting electric properties of the toner even when used for a long period of time and having excellent image density stability without bringing about image deletion and blurring. The toner includes colored particles containing at least a binder resin and a colorant, and two or more external additives. At least one of the external additives includes hydrophobic treated mesoporous particles, and the mesoporous particles are inorganic particles of at least one type selected from the group consisting of silica, titanium oxide, alumina, cerium oxide, and strontium titanate.

Abstract translation: 提供使用调色剂的调色剂和电子照相设备以及使用调色剂的电子照相处理盒，其具有优异的电荷稳定性，而不会不利地影响调色剂的电性能，即使长时间使用并且具有优异的图像密度稳定性而不引起图像缺失， 模糊。 调色剂包括至少含有粘合剂树脂和着色剂的着色颗粒，以及两种或更多种外部添加剂。 至少一种外部添加剂包括疏水处理的介孔颗粒，并且介孔颗粒是选自二氧化硅，氧化钛，氧化铝，氧化铈和钛酸锶中的至少一种的无机颗粒。

公开(公告)号：US07241547B2

公开(公告)日：2007-07-10

申请号：US11485467

申请日：2006-07-13

Applicant: Tsuyoshi Takiguchi ,  Yosuke Morikawa ,  Takashige Kasuya ,  Kimihiro Yoshimura ,  Katsuhisa Yamazaki ,  Kaori Hiratsuka

Inventor： Tsuyoshi Takiguchi ,  Yosuke Morikawa ,  Takashige Kasuya ,  Kimihiro Yoshimura ,  Katsuhisa Yamazaki ,  Kaori Hiratsuka

IPC: G03G21/10

CPC classification number: G03G9/09725 ,  G03G9/0819 ,  G03G9/0821 ,  G03G9/08755 ,  G03G9/09708 ,  G03G15/0241

Abstract: A toner exhibits excellent image characteristics, and also has an excellent charging property even if the toner is used in a cleaning-simultaneous-with-developing system having a direct injection charging mechanism. The toner includes toner particles and non-magnetic metallic-compound fine particles. The weight average particle diameter of the toner is 3.0 μm to 12.0 μm. The metallic-compound fine particles are conductive metallic-compound fine particles having a specific surface area (cm2/cm3) of 5×105 to 100×105; a medium diameter (D50) of 0.4 μm to 4.0 μm with respect to a volume-based particle diameter distribution, the medium diameter (D50) being smaller than the weight average particle diameter of the toner; and a 90% particle diameter D90 of 6.0 μm or less with respect to a volume-based particle diameter.

Abstract translation: 调色剂表现出优异的图像特性，并且即使将调色剂用于具有直接注入充电机构的同时显影清洗系统中也具有优异的充电特性。 调色剂包括调色剂颗粒和非磁性金属化合物细颗粒。 调色剂的重均粒径为3.0μm〜12.0μm。 金属化合物微粒是具有5×10 5以上的比表面积（cm 2以上/ cm 3以下）的导电性金属化合物微粒〜 100×10 5; 相对于基于体积的粒径分布为0.4μm至4.0μm的中等直径（D≤50），中等直径（D≤50<）小于重量 调色剂的平均粒径; 和相对于基于体积的粒径为6.0μm或更小的90％粒径D 90 N。

公开(公告)号：US20070147886A1

公开(公告)日：2007-06-28

申请号：US11681856

申请日：2007-03-05

Applicant: Tsuyoshi TAKIGUCHI ,  Yosuke Morikawa ,  Takashige Kasuya ,  Kimihiro Yoshimura ,  Katsuhisa Yamazaki ,  Kaori Hiratsuka

Inventor： Tsuyoshi TAKIGUCHI ,  Yosuke Morikawa ,  Takashige Kasuya ,  Kimihiro Yoshimura ,  Katsuhisa Yamazaki ,  Kaori Hiratsuka

IPC: G03G15/00

CPC classification number: G03G9/09725 ,  G03G9/0819 ,  G03G9/0821 ,  G03G9/08755 ,  G03G9/09708 ,  G03G15/0241

Abstract: A toner exhibits excellent image characteristics, and also has an excellent charging property even if the toner is used in a cleaning-simultaneous-with-developing system having a direct injection charging mechanism. The toner includes toner particles and non-magnetic metallic-compound fine particles. The weight average particle diameter of the toner is 3.0 μm to 12.0 μm. The metallic-compound fine particles are conductive metallic-compound fine particles having a specific surface area (cm2/cm3) of 5×105 to 100×105; a medium diameter (D50) of 0.4 μm to 4.0 μm with respect to a volume-based particle diameter distribution, the medium diameter (D50) being smaller than the weight average particle diameter of the toner; and a 90% particle diameter D90 of 6.0 μm or less with respect to a volume-based particle diameter.

Abstract translation: 调色剂表现出优异的图像特性，并且即使将调色剂用于具有直接注入充电机构的同时显影清洗系统中也具有优异的充电特性。 调色剂包括调色剂颗粒和非磁性金属化合物细颗粒。 调色剂的重均粒径为3.0μm〜12.0μm。 金属化合物微粒是具有5×10 5以上的比表面积（cm 2以上/ cm 3以上）的导电性金属化合物微粒〜 100x10 5; 相对于基于体积的粒径分布为0.4μm至4.0μm的中等直径（D≤50），中等直径（D <50>）为 小于调色剂的重均粒径; 和相对于基于体积的粒径为6.0μm或更小的90％粒径D 90 N。

公开(公告)号：US20060257772A1

公开(公告)日：2006-11-16

申请号：US11485467

申请日：2006-07-13

Applicant: Tsuyoshi Takiguchi ,  Yosuke Morikawa ,  Takashige Kasuya ,  Kimihiro Yoshimura ,  Katsuhisa Yamazaki ,  Kaori Hiratsuka

Inventor： Tsuyoshi Takiguchi ,  Yosuke Morikawa ,  Takashige Kasuya ,  Kimihiro Yoshimura ,  Katsuhisa Yamazaki ,  Kaori Hiratsuka

IPC: G03G9/08

CPC classification number: G03G9/09725 ,  G03G9/0819 ,  G03G9/0821 ,  G03G9/08755 ,  G03G9/09708 ,  G03G15/0241

Abstract: A toner exhibits excellent image characteristics, and also has an excellent charging property even if the toner is used in a cleaning-simultaneous-with-developing system having a direct injection charging mechanism. The toner includes toner particles and non-magnetic metallic-compound fine particles. The weight average particle diameter of the toner is 3.0 μm to 12.0 μm. The metallic-compound fine particles are conductive metallic-compound fine particles having a specific surface area (cm2/cm3) of 5×105 to 100×105; a medium diameter (D50) of 0.4 μm to 4.0 μm with respect to a volume-based particle diameter distribution, the medium diameter (D50) being smaller than the weight average particle diameter of the toner; and a 90% particle diameter D90 of 6.0 μm or less with respect to a volume-based particle diameter.