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公开(公告)号：US11554226B2
公开(公告)日：2023-01-17
申请号：US16875282
申请日：2020-05-15
摘要： A system may include an external device and an inhaler. The external device may include a processor, a communication circuit, and memory. The inhaler may include a mouthpiece, medicament, a mechanical dose counter, and an electronics module comprising a processor and a communication circuit. The electronics module may record a dosing event when the inhaler is actuated, such as when the mouthpiece cover is opened, and send a signal indicating the dosing event to the external device. The external device may receive a mechanical dose reading of the mechanical dose counter, determine an electronic dose reading based on the signal indicating the dosing event, determine that a discrepancy between the mechanical dose reading and the electronic dose reading exceeds a threshold, and notify the user of the discrepancy, for example, by providing a notification to the user by way of a mobile application residing on the external device.
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公开(公告)号：US20220401667A1
公开(公告)日：2022-12-22
申请号：US17896526
申请日：2022-08-26
发明人： Xinyu Liu , Jenna-Leigh Meola , Cody Goldberg , Jinn Kim , Sunil Kumar Mishra , Vered Ben-Anat
摘要： Provided is a system comprising a plurality of inhalers that each include a processor configured to determine a value of a usage parameter relating to use of the respective first inhaler, encrypt data based on the value, and transmit the encrypted data. At least two of the inhalers include different medicament, such as a rescue medicament and a maintenance medicament. The system includes an external device that includes a processor configured to distinguish between the encrypted data of each respective inhaler, determine respective usage information relating to each of the distinct types of medicament based on the respective encrypted data, and control a user interface (e.g., of the external device) to communicate the usage information related to each inhaler and/or each respective type of medicament.
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公开(公告)号：US11464923B2
公开(公告)日：2022-10-11
申请号：US16906896
申请日：2020-06-19
发明人： Xinyu Liu , Jenna-Leigh Meola , Cody Goldberg , Jinn Kim , Sunil Kumar Mishra , Vered Ben-Anat
IPC分类号： A61M15/00 , A61M11/02 , G16H40/67 , A61B5/087 , G16H20/13 , G06F21/60 , G06K7/14 , H04L9/40 , A61B5/00 , A61M11/00 , A61M16/00
摘要： Provided is a system including a plurality of inhalers that each include a processor configured to determine a value of a usage parameter relating to use of the respective first inhaler, encrypt data based on the value, and transmit the encrypted data. At least two of the inhalers include different medicament, such as a rescue medicament and a maintenance medicament. The system includes an external device that includes a processor configured to distinguish between the encrypted data of each respective inhaler, determine respective usage information relating to each of the distinct types of medicament based on the respective encrypted data, and control a user interface (e.g., of the external device) to communicate the usage information related to each inhaler and/or each respective type of medicament.
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公开(公告)号：US20220148730A1
公开(公告)日：2022-05-12
申请号：US17505821
申请日：2021-10-20
发明人： Michael Naumov , Yaron Nir
摘要： A system may include a plurality of inhalers, where each inhaler comprising medicament, a processor, memory, and a transmitter, multiple processing modules that may reside at least partially on a user device, a digital health platform (DHP) that is configured to receive and aggregate inhaler data from inhalers that are associated with a plurality of different users and a plurality of different medicament types. The DHP may be configured to train a machine learning algorithm using training data via a supervised or an unsupervised learning method, wherein the training data comprises the time and the one or more inhalation parameters associated with each of the plurality of usage events. The DHP also configured to generate a compliance score, a future compliance score, and/or a risk score using the trained machine learning algorithm, and cause a display device to generate a notification indicating the score for the user.
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公开(公告)号：US20210393892A1
公开(公告)日：2021-12-23
申请号：US16906651
申请日：2020-06-19
发明人： Amir Zur , Xinyu Liu , Mark Milton-Edwards
IPC分类号： A61M15/00
摘要： Provided is a system comprising an inhaler. The inhaler comprises a use determination system. The use determination system is configured to determine a parameter relating to airflow during a use of the inhaler by a subject. The use determination system also assigns a time to the use. The system also comprises a user interface, and a processing module. The processing module is configured to determine inhalation information from the parameter, and control the user interface to issue a notification that the inhalation information is available. The notification is issued at a notification time. The processing module is configured to implement a deliberate time delay such that the notification time is delayed relative to the time assigned to the use.
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公开(公告)号：US11000653B2
公开(公告)日：2021-05-11
申请号：US15704444
申请日：2017-09-14
发明人： Enrique Calderon Oliveras , Daniel Buck , Erica Jamie Kantor , Ross William Weir , James Roche , Steven David Gardner , Robert Owen Kivlin
摘要： The introduction of electronics into a drug delivery device may introduce certain technical challenges, such as durability, electro-mechanical integration, and drug delivery performance. The present disclosure provides solutions for inclusion of an electronics module with an inhaler. For example, heat stakes may be used to secure a printed circuit board (PCB) to an electronics module's housing. Also for example, a slider may be used to transfer vertical movement of an inhaler's yoke to an electronics module's switch. Also for example, certain seals may be used when interfacing the electronics module to other portions of the device's housing to achieve a desired performance.
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公开(公告)号：US10792447B2
公开(公告)日：2020-10-06
申请号：US16258330
申请日：2019-01-25
发明人： Declan Walsh , Paul Prendergast , Daniel Buck , Trevor Kent , Niall Thompson
摘要： A breath actuated metered dose inhaler may include a canister fire system configured to fire a medicament containing canister in response to patient inhalation. The canister fire system may include a pneumatic force holding unit and having a rest configuration in which a metering valve of the canister is in a refill configuration; a prepared configuration in which a canister actuation force is retained by the pneumatic force holding unit and the canister fire system is actuatable by patient inhalation induced airflow; and a fire configuration in which the metering valve is in a dose delivery position. When in the prepared configuration, the force retained by the so pneumatic force holding unit may be reduced by less than about 6% over a period of 5 minutes, preferably less than about 3% over a period of 5 minutes.
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公开(公告)号：US10561808B2
公开(公告)日：2020-02-18
申请号：US15262818
申请日：2016-09-12
发明人： Declan Walsh , Derek Fenlon , Simon Kaar , Jan Geert Hazenberg , Daniel Buck , Paul Clancy , Robert Charles Uschold , Jeffrey A. Karg
摘要： A dose counter for an inhaler includes a counter display arranged to indicate dosage information, and a drive system arranged to move the counter display incrementally in a first direction from a first station to a second station in response to actuation input. A regulator is provided which is arranged to act upon the counter display at the first station to regulate motion of the counter display at the first station to incremental movements.
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公开(公告)号：US10086156B2
公开(公告)日：2018-10-02
申请号：US14699567
申请日：2015-04-29
发明人： Declan Walsh , Derek Fenlon , Simon Kaar , Jan Geert Hazenberg , Daniel Buck , Paul Clancy , Robert Charles Uschold , Jeffrey A. Karg
摘要： A dose counter for a metered dose inhaler includes an incremental counting system for counting doses. The incremental counting system has a main body, an actuator arranged to be driven in response to canister motion and to drive an incremental output member in response to canister motion. The actuator and incremental output member are configured to have predetermined canister fire and count configurations in a canister fire sequence. The canister fire configuration is determined by a position of the actuator relative to a datum at which the canister fires medicament and the count configuration is determined by a position of the actuator relative to the datum at which the incremental count system makes an incremental count. The actuator is arranged to reach a position in the count configuration at or after a position in the canister fire configuration.
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公开(公告)号：US10022510B2
公开(公告)日：2018-07-17
申请号：US15271738
申请日：2016-09-21
发明人： Declan Walsh , Derek Fenlon , Simon Kaar , Jan Geert Hazenberg , Daniel Buck , Paul Clancy , Robert Charles Uschold , Jeffrey A. Karg
摘要： A tape system for a dose counter for an inhaler, the tape system having a main elongate tape structure, dosing indicia located on the main elongate tape structure, tape positioning indicia located on the main elongate tape structure, a tape size marker located on the main elongate tape structure indicating a number of dosing indicia on the tape, and priming indicia located on the main elongate tape structure, the priming indicia being located between the dosing indicia and one end of the tape.
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