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    INHALER SYSTEM
    1.
    发明申请
    INHALER SYSTEM 有权

    公开(公告)号：US20220203050A1

    公开(公告)日：2022-06-30

    申请号：US17607442

    申请日：2020-04-30

    申请人： Norton (Waterford) Limited

    发明人： Mark Milton-Edwards ,  Guilherme Safioti ,  Lena Granovsky ,  Michael Reich

    IPC分类号： A61M15/00 ,  G16H20/13

    摘要： Provided is a system (10) for determining a probability of a CORD exacerbation in a subject. The system comprises a first inhaler (100) for delivering a rescue medicament to the subject. The rescue medicament may be suitable for treating the subject's acute respiratory disease, for example by effecting rapid dilation of the bronchi and bronchioles upon inhalation of the medicament. The first inhaler has a use-detection system (12B) configured to determine a rescue inhalation performed by the subject using the first inhaler. The system optionally includes a second inhaler for delivering a maintenance medicament to the subject during a routine inhalation A sensor system (12A) is configured to measure a parameter relating to airflow during the rescue inhalation and/or during the routine inhalation, when the second inhaler is included in the system. The system further comprises a processor (14) configured to determine a number of the rescue inhalations during a first time period, and receive the parameter measured for at least some of the rescue and/or routine inhalations. The processor then determines, using a weighted model, the probability of the CORD exacerbation based on the number of rescue inhalations and the parameters. The model is weighted such that the parameters are more significant in the probability determination than the number of rescue inhalations. Further provided is a method for determining the probability of a COPD exacerbation in a subject, which method employs the weighted model.

    INHALER SYSTEM
    4.
    发明申请
    INHALER SYSTEM 有权

    公开(公告)号：US20230034037A1

    公开(公告)日：2023-02-02

    申请号：US17786891

    申请日：2020-12-17

    申请人： Norton (Waterford) Limited

    发明人： Mark Milton-Edwards ,  Guilherme Safioti ,  Michael Reich

    IPC分类号： A61M15/00

    摘要： Provided is a system comprising at least one inhaler. Each of the at least one inhaler comprises a use determination system configured to determine at least one value of a usage parameter relating to use of the respective inhaler by a subject. The system further comprises a user interface and a processing module. The user interface is configured to enable user-inputting of an indication of a status of a respiratory disease being experienced by the subject. The processing module is configured to control the user interface to issue a prompt to input the indication based on the at least one value.

    INHALER SYSTEM
    5.
    发明申请
    INHALER SYSTEM 有权

    公开(公告)号：US20210393892A1

    公开(公告)日：2021-12-23

    申请号：US16906651

    申请日：2020-06-19

    申请人： Norton (Waterford) Limited

    发明人： Amir Zur ,  Xinyu Liu ,  Mark Milton-Edwards

    IPC分类号： A61M15/00

    摘要： Provided is a system comprising an inhaler. The inhaler comprises a use determination system. The use determination system is configured to determine a parameter relating to airflow during a use of the inhaler by a subject. The use determination system also assigns a time to the use. The system also comprises a user interface, and a processing module. The processing module is configured to determine inhalation information from the parameter, and control the user interface to issue a notification that the inhalation information is available. The notification is issued at a notification time. The processing module is configured to implement a deliberate time delay such that the notification time is delayed relative to the time assigned to the use.

    INHALER SYSTEM
    8.
    发明公开
    INHALER SYSTEM 审中-公开

    公开(公告)号：US20240225479A1

    公开(公告)日：2024-07-11

    申请号：US18558902

    申请日：2022-04-29

    申请人： Norton (Waterford) Limited

    发明人： Guilherme Safioti ,  Mark Milton-Edwards ,  Michael Reich

    IPC分类号： A61B5/08 ,  A61M15/00 ,  G16H50/20

    CPC分类号： A61B5/082 ,  A61M15/0001 ,  G16H50/20 ,  A61M2205/3334

    摘要： Provided is a method for generating an assessment of a respiratory disease in a subject at a current point in time. The method comprises determining a baseline statistic relating to usage of an inhaler in a baseline period. The inhaler is configured to deliver a rescue medicament to the subject, and has a use determination system configured to determine usage of the inhaler by the subject. The method also comprises determining a current statistic relating to usage of the inhaler in a current period containing the current point in time. The method further comprises generating a comparator variable. Generating the comparator variable comprises comparing the current statistic and the baseline statistic. The assessment of the respiratory disease is based on the comparator variable.

    INHALER SYSTEM
    9.
    发明公开
    INHALER SYSTEM 审中-公开

    公开(公告)号：US20240108826A1

    公开(公告)日：2024-04-04

    申请号：US18558126

    申请日：2022-04-29

    申请人： Norton (Waterford) Limited

    发明人： Mark Milton-Edwards

    IPC分类号： A61M15/00 ,  A61K31/573

    CPC分类号： A61M15/0065 ,  A61K31/573 ,  A61M15/0026 ,  A61M2205/3334 ,  A61M2205/3553

    摘要： Provided is a pharmaceutical composition comprising an oral corticosteroid for use in post-exacerbation treatment of a respiratory disease in a subject, which post-exacerbation treatment includes an initial dose of the oral corticosteroid. The post-exacerbation treatment being continued until fulfilment of an inhalation parameter criterion by one or more post-exacerbation inhalations performed by the subject with at least one inhaler and/or fulfilment of a rescue inhaler usage criterion relating to post-exacerbation usage of a rescue inhaler configured to deliver a rescue medicament to the subject, at which point the dose of the oral corticosteroid is changed from the initial dose. Further provided are systems and methods for determining whether the inhalation parameter criterion is fulfilled and for comparing a post-exacerbation value of an inhalation parameter to a baseline value of the inhalation parameter.