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    DEFORMABLE MIRROR DEVICE AND APPARATUS FOR OBSERVING RETINA OF EYE USING THE SAME
    31.
    发明申请
    DEFORMABLE MIRROR DEVICE AND APPARATUS FOR OBSERVING RETINA OF EYE USING THE SAME 失效
    用于观察眼睛的眼睛的可变形镜子装置和装置

    公开(公告)号：US20090040462A1

    公开(公告)日：2009-02-12

    申请号：US12186142

    申请日：2008-08-05

    Applicant: Kei MASUNISHI ,  Akihiro KOGA ,  Ryo FURUKAWA ,  Osamu NISHIMURA ,  Akio KOBAYASHI ,  Hiroyuki KAWASHIMA

    Inventor： Kei MASUNISHI ,  Akihiro KOGA ,  Ryo FURUKAWA ,  Osamu NISHIMURA ,  Akio KOBAYASHI ,  Hiroyuki KAWASHIMA

    IPC: A61B3/10 ,  G02B7/188

    CPC classification number: G02B26/0825 ,  A61B3/10

    Abstract: A deformable mirror device includes a substrate; a plurality of electrodes provided on the substrate; a spacer disposed on the substrate; a support member disposed above the spacer and having an opening passing through from a first face of the support member facing to the substrate to a second face of the support member opposite from the first face; a deformable electrode film formed below the first face of the support member so as to be opposed to the electrodes with a distance and so as to cover the opening; an insulation film provided between the deformable electrode film and the support member; and a reflection film provided on a face of the deformable electrode film opposite from the electrodes so as to overlap the opening. The electrodes are electrically insulated each other by a plurality of grooves radially extending from a region which includes a position corresponding to a center of the opening.

    Abstract translation: 可变形反射镜装置包括：基板; 设置在所述基板上的多个电极; 设置在基板上的间隔件; 支撑构件，设置在所述间隔件上方，并且具有从所述支撑构件的面向所述基板的第一面穿过到与所述第一面相对的所述支撑构件的第二面的开口; 可变电极膜，形成在所述支撑构件的所述第一面的下方，以与所述电极相对并且覆盖所述开口; 设置在所述可变形电极膜和所述支撑构件之间的绝缘膜; 以及反射膜，设置在与电极相对的可变形电极膜的表面上以与开口重叠。 电极通过从包括与开口的中心对应的位置的区域径向延伸的多个槽电绝缘。

    PIEZOELECTRIC MOTOR AND CAMERA DEVICE
    32.
    发明申请
    PIEZOELECTRIC MOTOR AND CAMERA DEVICE 有权
    压电电机和相机设备

    公开(公告)号：US20090039734A1

    公开(公告)日：2009-02-12

    申请号：US12186882

    申请日：2008-08-06

    Applicant: Hiroshi Takahashi ,  Takahiro Kokubo ,  Osamu Nishimura ,  Toshikatsu Akiba

    Inventor： Hiroshi Takahashi ,  Takahiro Kokubo ,  Osamu Nishimura ,  Toshikatsu Akiba

    IPC: H02N2/04 ,  H04N5/232

    CPC classification number: H04N5/2251 ,  H02N2/0025 ,  H02N2/103 ,  H02N2/108

    Abstract: A piezoelectric motor includes: a driven member having a substantially spherical shape; a base; a support member provided on the base; a gimbal frame that is provided on a periphery of the driven member; a first bearing that couples the gimbal frame to the support member to be rotatable around a first rotation axis; a second bearing that couples the driven member to the gimbal frame to be rotatable around a second rotation axis that is orthogonal to the first rotation axis; a plurality of piezoelectric elements, each of which has one end fixed onto the base and the other end disposed to be in contact with an actuation portion that abuts the driven member; and an elastic portion that is formed on the gimbal frame, the elastic portion being displaceable in a direction orthogonal to the first rotation axis and the second rotation axis.

    Abstract translation: 压电马达包括：具有大致球形的从动构件; 一个基地 设置在基座上的支撑构件; 设置在被驱动构件的周边上的万向架框架; 第一轴承，其将所述万向架框架联接到所述支撑构件以围绕第一旋转轴线旋转; 第二轴承，其将所述从动构件联接到所述万向架框架，以围绕与所述第一旋转轴线正交的第二旋转轴线旋转; 多个压电元件，每个压电元件的一端固定在基座上，另一端设置成与抵靠从动构件的致动部分接触; 以及形成在所述万向架框架上的弹性部分，所述弹性部分可在与所述第一旋转轴线和所述第二旋转轴线正交的方向上移位。

    Active sound muffler and active sound muffling method
    33.
    发明授权
    Active sound muffler and active sound muffling method 失效
    主动消声器和主动声音消声法

    公开(公告)号：US07352870B2

    公开(公告)日：2008-04-01

    申请号：US10400564

    申请日：2003-03-28

    Applicant: Akihiko Enamito ,  Osamu Nishimura ,  Tsutomu Shioyama

    Inventor： Akihiko Enamito ,  Osamu Nishimura ,  Tsutomu Shioyama

    IPC: H03B29/00 ,  H04B15/00 ,  F01N1/06

    CPC classification number: G10K11/178 ,  G10K2210/118 ,  G10K2210/124 ,  G10K2210/128 ,  G10K2210/3214 ,  G10K2210/3224

    Abstract: An active sound muffler for reducing a sound to be reduced as emitted from a sound source located at one of the opposite sides of a sound insulating wall and diffracted and transmitted to the other side, the muffler comprises a control loudspeaker arranged at the front end or the other side of the sound insulating wall and adapted to output a control sound with a predetermined amplitude and a predetermined phase, a control microphone arranged above the sound insulating wall and adapted to gauge the sound pressure or the acoustic intensity of the sound to be reduced and that of the control sound and a control circuit for controlling the output of the control loudspeaker so as to minimize the sound pressure or the acoustic intensity, whichever appropriate, based on the outcome of gauging of the control microphone, and the control loudspeaker showing a line sound source characteristic.

    Abstract translation: 一种主动声音消音器，用于减少从位于隔音壁的相对侧中的一个声音处发射并被衍射并传播到另一侧的声源被减小的声音消音器，消声器包括设置在前端的控制扬声器或 隔音墙的另一侧，适于输出具有预定振幅和预定相位的控制声音，控制麦克风布置在隔音墙上方，适用于测量声音的声压或声强度。 以及用于控制控制扬声器的输出的控制电路的控制电路，以便基于控制麦克风的测量结果，以最小化声压或声强度（以适当的方式），并且控制扬声器显示为 线声源特征。

    Cyclic amine compounds as CCR5 antagonists
    34.
    发明授权
    Cyclic amine compounds as CCR5 antagonists 有权
    环胺化合物作为CCR5拮抗剂

    公开(公告)号：US07348324B2

    公开(公告)日：2008-03-25

    申请号：US10273111

    申请日：2002-10-18

    Applicant: Shinichi Imamura ,  Shohei Hashiguchi ,  Taeko Hattori ,  Osamu Nishimura ,  Naoyuki Kanzaki ,  Masanori Baba ,  Yoshihiro Sugihara

    Inventor： Shinichi Imamura ,  Shohei Hashiguchi ,  Taeko Hattori ,  Osamu Nishimura ,  Naoyuki Kanzaki ,  Masanori Baba ,  Yoshihiro Sugihara

    IPC: A61P31/18 ,  A61K31/535 ,  A61K31/4965 ,  A61K31/44 ,  A61K31/47 ,  C07D413/00 ,  C07D241/00 ,  C07D211/00

    CPC classification number: C07D401/12 ,  C07D211/58 ,  C07D211/62 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/14

    Abstract: A compound of formula (I) (wherein R1 is a hydrogen atom, a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, R2 is a hydrocarbon group which may be substituted, a non-aromatic heterocyclic group which may be substituted, or R1 and R2 may combine to each other together with A to form a heterocyclic group which may be substituted; A is N or N+—R5.Y− (R5 is a hydrocarbon group; Y− is a counter anion); R3 is a cyclic hydrocarbon group which may be substituted or a heterocyclic group which may be substituted; n is 0 or 1; R4 is a hydrogen atom, a hydrocarbon group which may be substituted, a heterocyclic group which may be substituted, an alkoxy group which may be substituted, an aryloxy group which may be substituted, or an amino group which may be substituted, E is a divalent aliphatic hydrocarbon group which may be substituted by group(s) other than oxo; G1 is a bond, CO or SO2; G2 is CO, SO2, NHCO, CONH or OCO; J is methine or a nitrogen atom; and each of Q and R is a bond or a divalent C1-3 aliphatic hydrocarbon which may be substituted; provided that J is methine when G2 is OCO, that one of Q and R is not a bond when the other is a bond and that each of Q and R is not substituted by oxo group(s) when G1 is a bond) or a salt thereof has a potent CCR5 antagonistic activity and can be advantageously used for the treatment or prevention of infectious disease of various HIV in human (e.g. AIDS).

    Abstract translation: 式（I）化合物（其中R 1为氢原子，可被取代的烃基，可被取代的非芳香族杂环基，R 2 O 2 >可以被取代的烃基，可以被取代的非芳族杂环基，或者R 1和R 2可以彼此结合形成A至 形成可以被取代的杂环基; A是N或N + - - - - - - - （R 5） SUP>为烃基; Y为 - 抗衡阴离子）; R 3为可被取代的环状烃基或可被取代的杂环基; n 为0或1; R 4为氢原子，可被取代的烃基，可被取代的杂环基，可被取代的烷氧基，可被取代的芳氧基 ，或可以被取代的氨基，E是可以是二价脂族烃基 被除氧基以外的基团取代; G 1是一个键，CO或SO 2; G 2是CO，SO 2，NHCO，CONH或OCO; J为次甲基或氮原子; 并且Q和R中的每一个是可被取代的键或二价C 1-3烷基脂族烃; 条件是当G 2 O是OCO时J为次甲基，当另一个为键并且Q和R各自不被氧代基取代时，Q和R中的一个不为键， 当G 1是一个键时）或其盐具有强的CCR5拮抗活性，并且可以有利地用于治疗或预防人类各种HIV感染性疾病（如艾滋病）。

    Method for enrichment/seperation of protein or peptide
    35.
    发明申请
    Method for enrichment/seperation of protein or peptide 审中-公开
    蛋白质或肽的富集/分离方法

    公开(公告)号：US20070112181A1

    公开(公告)日：2007-05-17

    申请号：US10582882

    申请日：2004-12-21

    Applicant: Makoto Watanabe ,  Eiichi Matsuo ,  Chikako Toda ,  Osamu Nishimura

    Inventor： Makoto Watanabe ,  Eiichi Matsuo ,  Chikako Toda ,  Osamu Nishimura

    IPC: C07K1/00

    CPC classification number: C07K1/24

    Abstract: The present invention finds a media that can highly selectively retain proteins or peptides to be enriched/separated, as well as provides a method for selectively enriching/separating proteins or peptides using such a media. A method for enrichment/separation of a protein or a peptide, comprising separating a protein or a peptide containing an amino acid residue with a π electron-containing group by using a media with a π electron-containing group. Preferably, the amino acid residue is a tryptophan residue or a tryptophan residue modified with a sulfenyl compound, and the media is a media with phenyl group.

    Abstract translation: 本发明找到能够高度选择性保留待富集/分离的蛋白质或多肽的培养基，以及提供使用这种培养基选择性富集/分离蛋白质或肽的方法。 用于富集/分离蛋白质或肽的方法，包括通过使用具有含π电子的基团的培养基来分离含有氨基酸残基的蛋白质或含有含π电子的基团的肽。 优选地，氨基酸残基是用巯基化合物修饰的色氨酸残基或色氨酸残基，并且培养基是具有苯基的培养基。

    Method for removing N-terminal methionine
    37.
    发明授权
    Method for removing N-terminal methionine 失效
    去除N-末端甲硫氨酸的方法

    公开(公告)号：US06309859B1

    公开(公告)日：2001-10-30

    申请号：US09436518

    申请日：1999-11-09

    Applicant: Osamu Nishimura ,  Masato Suenaga ,  Hiroaki Ohmae ,  Shinji Tsuji

    Inventor： Osamu Nishimura ,  Masato Suenaga ,  Hiroaki Ohmae ,  Shinji Tsuji

    IPC: C12P2106

    CPC classification number: C07K1/12

    Abstract: The present invention provides a method for chemically removing a N-terminal methionine residue selectively, specifically and efficiently from a peptide or a salt thereof having an optionally oxidized methinine residue at its N-terminal. The method reacts a peptide or a salt thereof having an optionally oxidized methinine residue at its N-terminal with an &agr;-diketone derivative, followed by hydrolysis.

    Abstract translation: 本发明提供了一种从其N-末端具有任选氧化的甲硫氨酸残基的肽或其盐选择性地，具体和有效地化学去除N末端甲硫氨酸残基的方法。 该方法使其N-末端具有任选氧化的甲硫氨酸残基的肽或其盐与α-二酮衍生物反应，然后水解。

    Anilide derivative, production and use thereof
    40.
    发明授权
    Anilide derivative, production and use thereof 失效
    苯胺衍生物，生产和使用

    公开(公告)号：US06235771B1

    公开(公告)日：2001-05-22

    申请号：US09463924

    申请日：2000-03-27

    Applicant: Mitsuru Shiraishi ,  Masanori Baba ,  Masaki Seto ,  Naoyuki Kanzaki ,  Osamu Nishimura

    Inventor： Mitsuru Shiraishi ,  Masanori Baba ,  Masaki Seto ,  Naoyuki Kanzaki ,  Osamu Nishimura

    IPC: A61K3138

    CPC classification number: C07D335/06 ,  A61K31/495 ,  A61K31/52 ,  A61K31/535 ,  A61K31/55 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7076 ,  A61K45/06 ,  C07D337/08 ,  C07D409/12 ,  C07D409/14 ,  C07F9/655372 ,  C07F9/65539 ,  A61K2300/00

    Abstract: This invention is to provide a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring; the ring A is an optionally substituted 6- to 7-membered ring; the ring B is an optionally substituted benzene ring; n is an integer of 1 or 2; Z is a chemical bond or a divalent group; R2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, (2) an optionally substituted nitrogen-containing heterocyclic ring group which may contain a sulfur atom or an oxygen atom as ring constituting atoms and wherein a nitrogen atom may form a quaternary ammonium, (3) a group binding through a sulfur atom or (4) a group of the formula:  wherein k is 0 or 1, and when k is 0, a phosphorus atom may form a phosphonium; and R5 and R6 are independently an optionally substituted hydrocarbon group, an optionally substituted hydroxy group or an optionally substituted amino group, and R5 and R6 may bind to each other to form a cyclic group together with the adjacent phosphorus atom, or a salt thereof , which is useful for antagonizing CCR5 and also for the prevention and treatment of infectious disease of HIV.

    Abstract translation: 本发明提供下式化合物：其中R 1为任选取代的5至6元环; 环A是任选取代的6至7元环; 环B是任选取代的苯环; n为1或2的整数; Z是化学键或二价基团; R2是（1）其中氮原子可以形成季铵的任选取代的氨基，（2）可以含有硫原子或氧原子作为构成原子的环的任选取代的含氮杂环基，其中 氮原子可以形成季铵，（3）通过硫原子结合的基团或（4）下式的基团：其中k为0或1，当k为0时，磷原子可以形成鏻; R 5和R 6各自独立地为任选取代的烃基，任选取代的羟基或任选取代的氨基，并且R 5和R 6可以彼此结合形成环状基团以及相邻的磷原子或其盐， 其可用于拮抗CCR5以及用于预防和治疗HIV感染性疾病。

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