公开(公告)号：US20080213264A1

公开(公告)日：2008-09-04

申请号：US11929668

申请日：2007-10-30

Applicant: Ajay Bhatia ,  Yasir A. W. Skeiky ,  Peter Probst

Inventor： Ajay Bhatia ,  Yasir A. W. Skeiky ,  Peter Probst

IPC: A61K39/00

CPC classification number: C07K14/295 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/51 ,  A61K2039/515 ,  A61K2039/5154 ,  A61K2039/53 ,  C07K2319/00

Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

公开(公告)号：US20070134234A1

公开(公告)日：2007-06-14

申请号：US11541449

申请日：2006-09-29

Applicant: Craig Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Jalal Vakili ,  Peter Probst

Inventor： Craig Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Jalal Vakili ,  Peter Probst

IPC: A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C07K16/46 ,  C12N5/06 ,  C12P21/08

CPC classification number: C12N9/16 ,  A61K38/162 ,  C07K14/005 ,  C07K14/70539 ,  C07K16/2803 ,  C07K2319/30 ,  C12N2710/24022 ,  C12N2710/24122

Abstract: The poxvirus proteins designated A41L and 130L bind to three receptor-like protein tyrosine phosphatases (RPTP), leukocyte common antigen related protein (LAR), RPTP-δ, and RPTP-σ, that are present on the cell surface of immune cells. When a host is infected with the poxvirus, binding of A41L to cell surface proteins on the host cells results in suppression of the immune response. The present invention provides agents such as antibodies, and antigen-binding fragments thereof, small molecules, aptamers, small interfering RNAs, and peptide-IgFc fusion polypeptides that interact with one or more of LAR, RPTP-δ, and RPTP-σ expressed by immune cells or interact with a polynucleotide encoding the RPTP. Also provided are RPTP Ig domain oligomers and Fc fusion polypeptides. Such agents are useful for treating an immunological disorder in a subject according to the methods described herein.

Abstract translation: 命名为A41L和130L的痘病毒蛋白与存在于免疫细胞的细胞表面上的三种受体样蛋白酪氨酸磷酸酶（RPTP），白细胞常见抗原相关蛋白（LAR），RPTP-delta和RPTP-sigma结合。 当宿主感染痘病毒时，A41L与宿主细胞上的细胞表面蛋白的结合导致免疫应答的抑制。 本发明提供诸如抗体及其抗原结合片段，小分子，适体，小干扰RNA和肽-IgFc融合多肽的试剂，其与LAR，RPTP-δ和RPTP-sigma中的一种或多种相互作用， 免疫细胞或与编码RPTP的多核苷酸相互作用。 还提供了RPTP Ig结构域寡聚体和Fc融合多肽。 根据本文所述的方法，这样的试剂可用于治疗受试者的免疫学障碍。

公开(公告)号：US06555115B1

公开(公告)日：2003-04-29

申请号：US09410568

申请日：1999-10-01

Applicant: Peter Probst ,  Ajay Bhatia ,  Yasir A. W. Skeiky ,  Shyian Jen ,  Erika Jean Stromberg

Inventor： Peter Probst ,  Ajay Bhatia ,  Yasir A. W. Skeiky ,  Shyian Jen ,  Erika Jean Stromberg

IPC: A61K39118

CPC classification number: C07K14/295 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00

Abstract: Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.