公开(公告)号：US07462357B2

公开(公告)日：2008-12-09

申请号：US10872155

申请日：2004-06-18

申请人： Ajay Bhatia ,  Yasir A. W. Skeiky ,  Peter Probst

发明人： Ajay Bhatia ,  Yasir A. W. Skeiky ,  Peter Probst

IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K39/02 ,  A61K39/118 ,  A61K38/00 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  A01N37/18

CPC分类号： C07K14/295 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/51 ,  A61K2039/515 ,  A61K2039/5154 ,  A61K2039/53 ,  C07K2319/00

摘要： Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

摘要翻译： 公开了用于诊断和治疗衣原体感染的化合物和方法。 提供的化合物包括含有衣原体抗原的至少一个抗原部分的多肽和编码这些多肽的DNA序列。 还提供了包含此类多肽或DNA序列的药物组合物和疫苗以及针对这些多肽的抗体。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的衣原体感染。

公开(公告)号：US06375955B1

公开(公告)日：2002-04-23

申请号：US09022765

申请日：1998-02-12

申请人： Steven G. Reed ,  Antonio Campos-Neto ,  John R. Webb ,  Davin C. Dillon ,  Yasir A. W. Skeiky ,  Ajay Bhatia ,  Peter Probst

发明人： Steven G. Reed ,  Antonio Campos-Neto ,  John R. Webb ,  Davin C. Dillon ,  Yasir A. W. Skeiky ,  Ajay Bhatia ,  Peter Probst

IPC分类号： A61K39008

CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  Y02A50/41

摘要： Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or DNA molecules encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.

摘要翻译： 公开了用于预防，治疗和检测利什曼病并刺激患者免疫应答的组合物和方法。 提供的化合物包括含有至少一种或多种利什曼原虫抗原的免疫原性部分或其变体的多肽。 还提供包含这些多肽的疫苗和药物组合物，或编码这些多肽的DNA分子，并且可以用于例如预防和治疗利什曼病以及利什曼原虫感染的检测。

公开(公告)号：US6166177A

公开(公告)日：2000-12-26

申请号：US208277

申请日：1998-12-08

申请人： Peter Probst ,  Ajay Bhatia ,  Yasir A. W. Skeiky

发明人： Peter Probst ,  Ajay Bhatia ,  Yasir A. W. Skeiky

IPC分类号： A61K39/00 ,  C07K14/295 ,  A61K38/00 ,  C07H21/04 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00

CPC分类号： C07K14/295 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00 ,  Y10S530/82 ,  Y10S530/825

摘要： Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydial antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

摘要翻译： 公开了用于诊断和治疗衣原体感染的化合物和方法。 提供的化合物包括含有衣原体抗原的至少一个抗原部分的多肽和编码这些多肽的DNA序列。 还提供了包含此类多肽或DNA序列的药物组合物和疫苗以及针对这些多肽的抗体。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的衣原体感染。

公开(公告)号：US08263089B2

公开(公告)日：2012-09-11

申请号：US11928873

申请日：2007-10-30

申请人： Ajay Bhatia ,  Yasir A. W. Skeiky ,  Peter Probst

发明人： Ajay Bhatia ,  Yasir A. W. Skeiky ,  Peter Probst

IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K39/02 ,  A61K39/118 ,  A61K38/00 ,  A01N37/18

CPC分类号： C07K14/295 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/51 ,  A61K2039/515 ,  A61K2039/5154 ,  A61K2039/53 ,  C07K2319/00

摘要： Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

摘要翻译： 公开了用于诊断和治疗衣原体感染的化合物和方法。 提供的化合物包括含有衣原体抗原的至少一个抗原部分的多肽和编码这些多肽的DNA序列。 还提供了包含此类多肽或DNA序列的药物组合物和疫苗以及针对这些多肽的抗体。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的衣原体感染。

公开(公告)号：US06638517B2

公开(公告)日：2003-10-28

申请号：US09874923

申请日：2001-06-04

申请人： Steven G. Reed ,  Antonio Campos-Neto ,  John R. Webb ,  Davin C. Dillon ,  Yasir A. W. Skeiky ,  Ajay Bhatia ,  Rhea N. Coler ,  Peter Probst ,  Mark Brannon

发明人： Steven G. Reed ,  Antonio Campos-Neto ,  John R. Webb ,  Davin C. Dillon ,  Yasir A. W. Skeiky ,  Ajay Bhatia ,  Rhea N. Coler ,  Peter Probst ,  Mark Brannon

IPC分类号： A61K39008

CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00 ,  Y02A50/41

摘要： Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.

公开(公告)号：US06613337B1

公开(公告)日：2003-09-02

申请号：US09639206

申请日：2000-08-14

申请人： Steven G. Reed ,  Antonio Campos-Neto ,  John R. Webb ,  Davin C. Dillon ,  Yasir A. W. Skeiky ,  Ajay Bhatia ,  Rhea Coler ,  Peter Probst

发明人： Steven G. Reed ,  Antonio Campos-Neto ,  John R. Webb ,  Davin C. Dillon ,  Yasir A. W. Skeiky ,  Ajay Bhatia ,  Rhea Coler ,  Peter Probst

IPC分类号： A61K39008

CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00 ,  Y02A50/41

摘要： Compositions and methods for preventing, treating and detecting leishmaniasis and stimulating immune responses in patients are disclosed. The compounds provided include polypeptides that contain at least an immunogenic portion of one or more Leishmania antigens, or a variant thereof. Vaccines and pharmaceutical compositions comprising such polypeptides, or polynucleotides encoding such polypeptides, are also provided and may be used, for example, for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmania infection.

公开(公告)号：US20090035296A1

公开(公告)日：2009-02-05

申请号：US11929672

申请日：2007-10-30

申请人： Ajay Bhatia ,  Yasir A. W. Skeiky ,  Peter Probst

发明人： Ajay Bhatia ,  Yasir A. W. Skeiky ,  Peter Probst

IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K14/435 ,  C07K16/00 ,  C12N15/63 ,  A61P31/04 ,  A61K35/12 ,  C12N5/00 ,  G01N33/53 ,  C12N5/08

CPC分类号： C07K14/295 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/51 ,  A61K2039/515 ,  A61K2039/5154 ,  A61K2039/53 ,  C07K2319/00

摘要： Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

公开(公告)号：US20080181918A1

公开(公告)日：2008-07-31

申请号：US11929620

申请日：2007-10-30

申请人： Ajay Bhatia ,  Yasir A. W. Skeiky ,  Peter Probst

发明人： Ajay Bhatia ,  Yasir A. W. Skeiky ,  Peter Probst

IPC分类号： A61K39/00 ,  A61K31/70 ,  A61K38/00 ,  A61P37/00

CPC分类号： C07K14/295 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/51 ,  A61K2039/515 ,  A61K2039/5154 ,  A61K2039/53 ,  C07K2319/00

摘要： Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

公开(公告)号：US06432916B1

公开(公告)日：2002-08-13

申请号：US09556877

申请日：2000-04-19

申请人： Peter Probst ,  Ajay Bhatia ,  Yasir A. W. Skeiky ,  Steven P. Fling

发明人： Peter Probst ,  Ajay Bhatia ,  Yasir A. W. Skeiky ,  Steven P. Fling

IPC分类号： A61K3800

CPC分类号： C07K14/295 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/51 ,  C07K2319/00 ,  Y10S435/975

摘要： Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

公开(公告)号：US08052975B2

公开(公告)日：2011-11-08

申请号：US11929665

申请日：2007-10-30

申请人： Ajay Bhatia ,  Yasir A. W. Skeiky ,  Peter Probst

发明人： Ajay Bhatia ,  Yasir A. W. Skeiky ,  Peter Probst

IPC分类号： A61K39/00 ,  A61K39/38 ,  A61K39/02 ,  A61K39/118 ,  A61K45/00 ,  A61K38/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K1/00

CPC分类号： C07K14/295 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/505 ,  A61K2039/51 ,  A61K2039/515 ,  A61K2039/5154 ,  A61K2039/53 ,  C07K2319/00

摘要： Compounds and methods for the diagnosis and treatment of Chlamydial infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a Chlamydia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided, together with antibodies directed against such polypeptides. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Chlamydial infection in patients and in biological samples.

摘要翻译： 公开了用于诊断和治疗衣原体感染的化合物和方法。 提供的化合物包括含有衣原体抗原的至少一个抗原部分的多肽和编码这些多肽的DNA序列。 还提供了包含此类多肽或DNA序列的药物组合物和疫苗以及针对这些多肽的抗体。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的衣原体感染。