公开(公告)号：US20100239579A1

公开(公告)日：2010-09-23

申请号：US12687334

申请日：2010-01-14

Applicant: Craig A. Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Peter Probst

Inventor： Craig A. Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Peter Probst

IPC: A61K39/395 ,  C07K16/08 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  G01N33/53 ,  A61P37/00 ,  C12N1/19

CPC classification number: C07K14/70596 ,  C07K2319/30

Abstract: Provide herein are fusion polypeptides that comprise a CD47 extracellular domain or a variant thereof that is fused to a Fc polypeptide. The fusion polypeptides are useful for treating an immunological disease or disorder in a subject according to the methods described herein. The fusion polypeptides are capable of suppressing immunoresponsiveness of an immune cell, inhibiting production of proinflammatory cytokines, including inhibiting immune complex-induced production of cytokines.

Abstract translation: 本文提供的是融合多肽，其包含与Fc多肽融合的CD47细胞外结构域或其变体。 根据本文所述的方法，融合多肽可用于治疗受试者的免疫疾病或病症。 融合多肽能够抑制免疫细胞的免疫反应性，抑制促炎细胞因子的产生，包括抑制免疫复合物诱导的细胞因子产生。

公开(公告)号：US20060018892A1

公开(公告)日：2006-01-26

申请号：US11219282

申请日：2005-09-02

Applicant: Howard Clarke ,  Robert DuBose ,  Steven Wiley

Inventor： Howard Clarke ,  Robert DuBose ,  Steven Wiley

IPC: A61K38/54 ,  C07H21/04 ,  C12N9/99

CPC classification number: C07K14/8121 ,  A61K38/00 ,  C07K2317/24 ,  G01N2333/8121

Abstract: This invention relates to Thypin, a new member of the human serpin polypeptide family, methods of making Thypin polypeptides and using these polypeptides to treat various medical disorders and to methods of screening for compounds that agonize or antagonize Thypin polypeptide activities.

公开(公告)号：US20050208046A1

公开(公告)日：2005-09-22

申请号：US10971250

申请日：2004-10-22

Applicant: Kristine Kim ,  Steven Wiley ,  Randal Ketchem ,  William Fanslow

Inventor： Kristine Kim ,  Steven Wiley ,  Randal Ketchem ,  William Fanslow

IPC: G01N33/50 ,  A61K31/7088 ,  A61K38/00 ,  A61K38/17 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P17/02 ,  A61P35/00 ,  A61P37/06 ,  C07K14/705 ,  C07K14/715 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566

CPC classification number: A61K39/3955 ,  A61K38/00 ,  C07K14/705 ,  C07K14/70575 ,  C07K14/70578 ,  C07K16/2878 ,  C07K2319/00 ,  C07K2319/30 ,  C07K2319/73

Abstract: The present invention provides the TWEAK receptor and methods for identifying and using agonists and antagonists of the TWEAK receptor. In particular, the invention provides methods of screening for agonists and antagonists and for treating diseases or conditions mediated by angiogenesis, such as solid tumors and vascular deficiencies of cardiac or peripheral tissue.

Abstract translation: 本发明提供TWEAK受体和用于鉴定和使用TWEAK受体的激动剂和拮抗剂的方法。 特别地，本发明提供筛选激动剂和拮抗剂并用于治疗血管生成介导的疾病或病症的方法，例如实心瘤和心脏或外周组织的血管缺陷。

公开(公告)号：US6134765A

公开(公告)日：2000-10-24

申请号：US473090

申请日：1999-12-28

Applicant: Steven Wiley Ward

Inventor： Steven Wiley Ward

IPC: B25B27/00 ,  B25B27/14

CPC classification number: B25B27/00 ,  B25B27/14 ,  Y10T29/53943

Abstract: A camshaft removal tool for connecting to a camshaft so that camshaft may be removed or inserted without damaging engine components. The camshaft removal tool includes a tubular member. The tubular member has a first end and a second end. The tubular member is hollow. A wall for connection to the camshaft is fixedly coupled to the second end of the tubular member. A plurality of mounting bores is located in the wall. A plurality of access slots in the peripheral wall offers access to the bores. Each of the access slots is oriented at the second end of the tubular member and extends toward the first end of the tubular member.

Abstract translation: 用于连接到凸轮轴的凸轮轴拆卸工具，使得凸轮轴可以被移除或插入而不损坏发动机部件。 凸轮轴去除工具包括管状构件。 管状构件具有第一端和第二端。 管状构件是中空的。 用于连接到凸轮轴的壁固定地联接到管状构件的第二端。 多个安装孔位于墙壁中。 周边墙壁中的多个通道槽提供对孔的通路。 每个进入狭槽在管状构件的第二端处定向并且朝向管状构件的第一端延伸。

公开(公告)号：US6007898A

公开(公告)日：1999-12-28

申请号：US46165

申请日：1998-03-23

Applicant: Dai W. Kim ,  Joseph Steven Wiley Haas ,  William Edward Bessey

Inventor： Dai W. Kim ,  Joseph Steven Wiley Haas ,  William Edward Bessey

IPC: A42B3/12 ,  A43B13/18 ,  B29C51/00 ,  B32B3/28 ,  D03D1/00 ,  D04B1/00 ,  D04H1/00 ,  D04H1/54 ,  D04H13/00 ,  D06C23/00 ,  B32B1/00 ,  B27N3/10 ,  B32B7/00

CPC classification number: B29C51/004 ,  D04B1/18 ,  D04H3/07 ,  D10B2503/041 ,  D10B2503/06 ,  D10B2505/08 ,  D10B2505/10 ,  Y10T428/2457 ,  Y10T428/24636 ,  Y10T428/24661 ,  Y10T442/3008 ,  Y10T442/3065 ,  Y10T442/313 ,  Y10T442/425

Abstract: Three dimensional fiber networks which are semi-rigid and dimensionally stable are made from textile fabrics that have projections and optional depressions which are compressible and return to their original shape after being compressed. The fiber networks are made by the thermo-mechanical deformation of textile fabrics that are in turn made from thermoplastic fibers. The fiber networks have particular utility as cushioning and impact absorbing materials.

Abstract translation: 半刚性且尺寸稳定的三维纤维网由具有可压缩的突起和可选的凹陷的织物制成，并在压缩后恢复其原始形状。 纤维网络由纺织织物的热机械变形制成，纺织织物又由热塑性纤维制成。 纤维网络具有缓冲和冲击吸收材料的特殊用途。

公开(公告)号：US20070072249A1

公开(公告)日：2007-03-29

申请号：US11634751

申请日：2006-12-06

Applicant: Peter Baum ,  Randal Ketchem ,  Robert DuBose ,  Steven Wiley ,  Keith Kerkof

Inventor： Peter Baum ,  Randal Ketchem ,  Robert DuBose ,  Steven Wiley ,  Keith Kerkof

IPC: G01N33/567 ,  C07H21/04 ,  C12P21/06 ,  C07K14/705 ,  C07K16/28

CPC classification number: G01N33/6863 ,  C07K14/435 ,  C12N2506/03 ,  G01N2500/00 ,  G01N2800/24

Abstract: This invention relates to new human alpha-helix-containing polypeptides, to methods of making such polypeptides, to methods of using them to treat immunological conditions, and to methods of identifying compounds that alter alpha-helix-containing polypeptide activities.

Abstract translation: 本发明涉及新的含人α-螺旋的多肽，制备这种多肽的方法，使用它们来治疗免疫学病症的方法，以及鉴定改变含有α-螺旋的多肽活性的化合物的方法。

公开(公告)号：US20050054829A1

公开(公告)日：2005-03-10

申请号：US10883144

申请日：2004-07-01

Applicant: Steven Wiley ,  Jalaleddin Vakili

Inventor： Steven Wiley ,  Jalaleddin Vakili

IPC: C07K14/47 ,  C07K14/78 ,  C12N9/10 ,  C07K14/52

CPC classification number: C07K14/47 ,  C07K14/78

Abstract: The present invention provides compositions and methods relating to polynucleotides and polypeptides derived from the TSP-30a, b, c, and d genes. In particular embodiments the invention provides polynucleotides and polypeptides derived from human, mouse, and zebrafish TSP-30 genes, for example, a novel class of four exon splice variants.

Abstract translation: 本发明提供了与衍生自TSP-30a，b，c和d基因的多核苷酸和多肽相关的组合物和方法。 在具体实施方案中，本发明提供了衍生自人，小鼠和斑马鱼TSP-30基因的多核苷酸和多肽，例如四种外显子剪接变体的新一类。

公开(公告)号：US20130129748A1

公开(公告)日：2013-05-23

申请号：US13616694

申请日：2012-09-14

Applicant: Steven Wiley ,  Craig A. Smith ,  Ajamete Kaykas

Inventor： Steven Wiley ,  Craig A. Smith ,  Ajamete Kaykas

IPC: G01N33/68 ,  A61K39/395 ,  C12Q1/70

CPC classification number: G01N33/6845 ,  A61K39/3955 ,  C12Q1/18 ,  C12Q1/70 ,  G01N33/5008 ,  G01N33/56983 ,  G01N2500/02

Abstract: The present invention provides methods for identifying viral virulence factors and for identifying cellular polypeptides to which the viral polypeptides bind. The cellular polypeptide is useful as a therapeutic target or as a therapeutic agent for treating diseases and disorders, including immunological diseases or disorders.

Abstract translation: 本发明提供用于鉴定病毒毒力因子和鉴定病毒多肽结合的细胞多肽的方法。 细胞多肽可用作治疗靶点或用作治疗疾病和病症（包括免疫疾病或病症）的治疗剂。

公开(公告)号：US20070134234A1

公开(公告)日：2007-06-14

申请号：US11541449

申请日：2006-09-29

Applicant: Craig Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Jalal Vakili ,  Peter Probst

Inventor： Craig Smith ,  Steven Wiley ,  Ajamete Kaykas ,  Jalal Vakili ,  Peter Probst

IPC: A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C07K16/46 ,  C12N5/06 ,  C12P21/08

CPC classification number: C12N9/16 ,  A61K38/162 ,  C07K14/005 ,  C07K14/70539 ,  C07K16/2803 ,  C07K2319/30 ,  C12N2710/24022 ,  C12N2710/24122

Abstract: The poxvirus proteins designated A41L and 130L bind to three receptor-like protein tyrosine phosphatases (RPTP), leukocyte common antigen related protein (LAR), RPTP-δ, and RPTP-σ, that are present on the cell surface of immune cells. When a host is infected with the poxvirus, binding of A41L to cell surface proteins on the host cells results in suppression of the immune response. The present invention provides agents such as antibodies, and antigen-binding fragments thereof, small molecules, aptamers, small interfering RNAs, and peptide-IgFc fusion polypeptides that interact with one or more of LAR, RPTP-δ, and RPTP-σ expressed by immune cells or interact with a polynucleotide encoding the RPTP. Also provided are RPTP Ig domain oligomers and Fc fusion polypeptides. Such agents are useful for treating an immunological disorder in a subject according to the methods described herein.

Abstract translation: 命名为A41L和130L的痘病毒蛋白与存在于免疫细胞的细胞表面上的三种受体样蛋白酪氨酸磷酸酶（RPTP），白细胞常见抗原相关蛋白（LAR），RPTP-delta和RPTP-sigma结合。 当宿主感染痘病毒时，A41L与宿主细胞上的细胞表面蛋白的结合导致免疫应答的抑制。 本发明提供诸如抗体及其抗原结合片段，小分子，适体，小干扰RNA和肽-IgFc融合多肽的试剂，其与LAR，RPTP-δ和RPTP-sigma中的一种或多种相互作用， 免疫细胞或与编码RPTP的多核苷酸相互作用。 还提供了RPTP Ig结构域寡聚体和Fc融合多肽。 根据本文所述的方法，这样的试剂可用于治疗受试者的免疫学障碍。

公开(公告)号：US20070020270A1

公开(公告)日：2007-01-25

申请号：US11527109

申请日：2006-09-25

Applicant: Howard Clarke ,  Robert DuBose ,  Steven Wiley

Inventor： Howard Clarke ,  Robert DuBose ,  Steven Wiley

IPC: A61K39/395 ,  G01N33/53 ,  C07H21/04 ,  C12P21/06 ,  C12N9/64

CPC classification number: C07K14/8121 ,  A61K38/00 ,  C07K2317/24 ,  G01N2333/8121

Abstract: This invention relates to Thypin, a new member of the human serpin polypeptide family, methods of making Thypin polypeptides and using these polypeptides to treat various medical disorders and to methods of screening for compounds that agonize or antagonize Thypin polypeptide activities.

Abstract translation: 本发明涉及Thypin，人丝氨酸蛋白酶多肽家族的新成员，制备Thypin多肽和使用这些多肽治疗各种医学病症的方法以及筛选激动或拮抗Thypin多肽活性的化合物的方法。